FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009053492> ?p ?o ?g. }

• W2009053492 endingPage "1520" @default.
• W2009053492 startingPage "1497" @default.
• W2009053492 abstract "INSM1 is a zinc-finger protein expressed in the developing nervous system and pancreas as well as in medulloblastomas and neuroendocrine tumors. With in situ hybridization combined with immunohistochemistry, we detected INSM1 mRNA in all embryonic to adult neuroproliferative areas examined: embryonic neocortex, ganglionic eminence, midbrain, retina, hindbrain, and spinal cord; autonomic, dorsal root, trigeminal and spiral ganglia; olfactory and vomeronasal organ epithelia; postnatal cerebellum; and juvenile to adult subgranular zone of dentate gyrus, subventricular zone, and rostral migratory stream leading to olfactory bulb. In most of these neurogenic areas, subsets of neuronal progenitors and nascent, but not mature, neurons express INSM1. For example, in developing cerebellum, INSM1 is present in proliferating progenitors of the outer external granule layer (EGL) and in postmitotic cells of the inner EGL, but not in mature granule cell neurons. Also, lining the neural tube from spinal cord to neocortex in mouse as well as human embryos, cells undergoing mitosis apically do not express INSM1. By contrast, nonsurface progenitors located in the basal ventricular and/or subventricular zones express INSM1. Whereas apical progenitors are proliferative and generate one or two additional progenitors, basal progenitors are thought to divide terminally and symmetrically to produce two neurons. The nematode ortholog of INSM1, EGL-46, is expressed during terminal symmetric neurogenic divisions and regulates the termination of proliferation. We propose that, in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions." @default.
• W2009053492 created "2016-06-24" @default.
• W2009053492 creator A5005687049 @default.
• W2009053492 creator A5027048040 @default.
• W2009053492 creator A5029843483 @default.
• W2009053492 creator A5044312992 @default.
• W2009053492 creator A5055929567 @default.
• W2009053492 creator A5063367443 @default.
• W2009053492 date "2008-01-01" @default.
• W2009053492 modified "2023-09-27" @default.
• W2009053492 title "Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis" @default.
• W2009053492 cites W1506357334 @default.
• W2009053492 cites W1516408025 @default.
• W2009053492 cites W1516412274 @default.
• W2009053492 cites W1549694960 @default.
• W2009053492 cites W1715204582 @default.
• W2009053492 cites W1832630348 @default.
• W2009053492 cites W1859730138 @default.
• W2009053492 cites W1937572154 @default.
• W2009053492 cites W1966005363 @default.
• W2009053492 cites W1967445973 @default.
• W2009053492 cites W1969389862 @default.
• W2009053492 cites W1970756199 @default.
• W2009053492 cites W1971305731 @default.
• W2009053492 cites W1974858997 @default.
• W2009053492 cites W1976862716 @default.
• W2009053492 cites W1979895839 @default.
• W2009053492 cites W1980499453 @default.
• W2009053492 cites W1980940171 @default.
• W2009053492 cites W1981379485 @default.
• W2009053492 cites W1983725263 @default.
• W2009053492 cites W1986926812 @default.
• W2009053492 cites W1988976106 @default.
• W2009053492 cites W1990894443 @default.
• W2009053492 cites W1990935914 @default.
• W2009053492 cites W1992665351 @default.
• W2009053492 cites W1993646910 @default.
• W2009053492 cites W2004908889 @default.
• W2009053492 cites W2007242343 @default.
• W2009053492 cites W2009311165 @default.
• W2009053492 cites W2019071873 @default.
• W2009053492 cites W2021184749 @default.
• W2009053492 cites W2024238415 @default.
• W2009053492 cites W2026167097 @default.
• W2009053492 cites W2026733576 @default.
• W2009053492 cites W2027873230 @default.
• W2009053492 cites W2030508161 @default.
• W2009053492 cites W2037831349 @default.
• W2009053492 cites W2042109654 @default.
• W2009053492 cites W2045295673 @default.
• W2009053492 cites W2046381759 @default.
• W2009053492 cites W2047293798 @default.
• W2009053492 cites W2055434206 @default.
• W2009053492 cites W2058740317 @default.
• W2009053492 cites W2059679976 @default.
• W2009053492 cites W2061556807 @default.
• W2009053492 cites W2063511140 @default.
• W2009053492 cites W2063620761 @default.
• W2009053492 cites W2068481295 @default.
• W2009053492 cites W2071353365 @default.
• W2009053492 cites W2072673889 @default.
• W2009053492 cites W2083092470 @default.
• W2009053492 cites W2084114120 @default.
• W2009053492 cites W2086788138 @default.
• W2009053492 cites W2088814620 @default.
• W2009053492 cites W2088851040 @default.
• W2009053492 cites W2091708438 @default.
• W2009053492 cites W2094073595 @default.
• W2009053492 cites W2097053397 @default.
• W2009053492 cites W2103021185 @default.
• W2009053492 cites W2104576151 @default.
• W2009053492 cites W2111197864 @default.
• W2009053492 cites W2112891548 @default.
• W2009053492 cites W2120504963 @default.
• W2009053492 cites W2124472672 @default.
• W2009053492 cites W2124908967 @default.
• W2009053492 cites W2127220436 @default.
• W2009053492 cites W2127535417 @default.
• W2009053492 cites W2131484319 @default.
• W2009053492 cites W2132691381 @default.
• W2009053492 cites W2138842865 @default.
• W2009053492 cites W2139450672 @default.
• W2009053492 cites W2140840483 @default.
• W2009053492 cites W2142585018 @default.
• W2009053492 cites W2142820864 @default.
• W2009053492 cites W2145430337 @default.
• W2009053492 cites W2148212562 @default.
• W2009053492 cites W2154536753 @default.
• W2009053492 cites W2155471406 @default.
• W2009053492 cites W2158154597 @default.
• W2009053492 cites W2159617943 @default.
• W2009053492 cites W2163380380 @default.
• W2009053492 cites W2163416892 @default.
• W2009053492 cites W2169123716 @default.
• W2009053492 cites W2170960097 @default.
• W2009053492 cites W2172202356 @default.
• W2009053492 cites W2329575852 @default.
• W2009053492 doi "https://doi.org/10.1002/cne.21629" @default.

• next