FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009055007> ?p ?o ?g. }

• W2009055007 endingPage "2325" @default.
• W2009055007 startingPage "2315" @default.
• W2009055007 abstract "Patients with diabetes mellitus that exhibit cardiac pump failure display compromised stroke volume, ejection fraction, and slower rates of rise and fall of left ventricular (LV) dP/dt in the absence of ischemic injury. We hypothesized that diabetic cardiomyopathy may involve decrements in adrenergic sensitivity, with specific molecular alterations in the beta-adrenergic receptor (beta AR)- G protein- adenylyl cyclase (AC) signal transduction system. We assessed the effects of 3 months of streptozotocin-induced diabetes (125 mg/kg i.v.; DIAB, n = 10) on myocardial signal transduction in mini-pigs. DIAB were hyperglycemic compared to controls (CON, n = 10; 20.92 +/- 2.64 v 5.24 +/- 0.35 mM glucose), and had lower fasting insulin levels (6.46 +/- 0.97 v 13.68 +/- 3.91 microU/ml). Transmural LV free wall homogenates from DIAB exhibited similar beta AR density as CON, but decreased cAMP production (pmol cAMP/mg prot.min) using these pharmacological stimulators: 10 microM Isoproterenol plus 100 microM GTP (74 +/- 5 v 97 +/- 11); 100 microM Gpp(NH)p (116 +/- 7 v 161 +/- 17); 10 mM fluoride ion (266 +/- 16 v 324 +/- 25). No differences between DIAB and CON were observed when stimulated by 100 microM forskolin (440 +/- 20 v 429 +/- 33), suggesting no alterations in the catalytic subunit of AC. In DIAB, quantitative immunoblotting indicated slightly depressed levels of Gs (552 +/- 44 v 630 +/- 59 pmol/g ww; NS), but a significant redistribution of alpha s from the sarcolemma to the cytosol (32.7 +/- 0.82% v 25.9 +/- 1.7%). Significantly elevated levels of cardiac Gi were seen in DIAB homogenates compared to CON ventricles (2326 +/- 145 v 1522 +/- 181 pmol/g ww), with no alpha i subunit redistribution. We conclude that despite maintained beta AR density, receptor-dependent and G protein-dependent stimulation of AC is depressed so that streptozotocin-induced diabetic LV is affected by increased cardiac Gi, redistribution of Gs alpha to the cytosol, and an increase in the Gi/Gs ratio. These results help explain depressed catecholamine responsiveness and cardiac performance exhibited by diabetic patients." @default.
• W2009055007 created "2016-06-24" @default.
• W2009055007 creator A5000554933 @default.
• W2009055007 creator A5003110659 @default.
• W2009055007 creator A5006522350 @default.
• W2009055007 creator A5034488510 @default.
• W2009055007 creator A5074110521 @default.
• W2009055007 date "1995-10-01" @default.
• W2009055007 modified "2023-09-30" @default.
• W2009055007 title "Adrenergic desensitization in left ventricle from streptozotocin diabetic swine" @default.
• W2009055007 cites W1567752146 @default.
• W2009055007 cites W1589058355 @default.
• W2009055007 cites W1603828997 @default.
• W2009055007 cites W1898305623 @default.
• W2009055007 cites W1959097863 @default.
• W2009055007 cites W1964246559 @default.
• W2009055007 cites W1971093878 @default.
• W2009055007 cites W1990851903 @default.
• W2009055007 cites W1992229507 @default.
• W2009055007 cites W1998953067 @default.
• W2009055007 cites W2000649145 @default.
• W2009055007 cites W2002930464 @default.
• W2009055007 cites W2009064952 @default.
• W2009055007 cites W2017107643 @default.
• W2009055007 cites W2020906956 @default.
• W2009055007 cites W2028965457 @default.
• W2009055007 cites W2034550794 @default.
• W2009055007 cites W2037796502 @default.
• W2009055007 cites W2043952202 @default.
• W2009055007 cites W2050297340 @default.
• W2009055007 cites W2062105646 @default.
• W2009055007 cites W2067223472 @default.
• W2009055007 cites W2082687598 @default.
• W2009055007 cites W2084636356 @default.
• W2009055007 cites W2085093754 @default.
• W2009055007 cites W2095647887 @default.
• W2009055007 cites W2101007077 @default.
• W2009055007 cites W2106705252 @default.
• W2009055007 cites W2111716072 @default.
• W2009055007 cites W2139819388 @default.
• W2009055007 cites W2140509492 @default.
• W2009055007 cites W2148488273 @default.
• W2009055007 cites W2165882508 @default.
• W2009055007 cites W2166266050 @default.
• W2009055007 cites W2169503005 @default.
• W2009055007 cites W2178536469 @default.
• W2009055007 cites W2414125751 @default.
• W2009055007 cites W4293247451 @default.
• W2009055007 doi "https://doi.org/10.1016/s0022-2828(95)91875-2" @default.
• W2009055007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8576946" @default.
• W2009055007 hasPublicationYear "1995" @default.
• W2009055007 type Work @default.
• W2009055007 sameAs 2009055007 @default.
• W2009055007 citedByCount "26" @default.
• W2009055007 countsByYear W20090550072013 @default.
• W2009055007 countsByYear W20090550072015 @default.
• W2009055007 countsByYear W20090550072017 @default.
• W2009055007 countsByYear W20090550072020 @default.
• W2009055007 countsByYear W20090550072021 @default.
• W2009055007 crossrefType "journal-article" @default.
• W2009055007 hasAuthorship W2009055007A5000554933 @default.
• W2009055007 hasAuthorship W2009055007A5003110659 @default.
• W2009055007 hasAuthorship W2009055007A5006522350 @default.
• W2009055007 hasAuthorship W2009055007A5034488510 @default.
• W2009055007 hasAuthorship W2009055007A5074110521 @default.
• W2009055007 hasConcept C126322002 @default.
• W2009055007 hasConcept C134018914 @default.
• W2009055007 hasConcept C170493617 @default.
• W2009055007 hasConcept C199096232 @default.
• W2009055007 hasConcept C207200792 @default.
• W2009055007 hasConcept C2776553924 @default.
• W2009055007 hasConcept C2778198053 @default.
• W2009055007 hasConcept C2778797674 @default.
• W2009055007 hasConcept C2778921608 @default.
• W2009055007 hasConcept C2779178603 @default.
• W2009055007 hasConcept C2779276759 @default.
• W2009055007 hasConcept C2779280383 @default.
• W2009055007 hasConcept C2779779143 @default.
• W2009055007 hasConcept C555293320 @default.
• W2009055007 hasConcept C71924100 @default.
• W2009055007 hasConceptScore W2009055007C126322002 @default.
• W2009055007 hasConceptScore W2009055007C134018914 @default.
• W2009055007 hasConceptScore W2009055007C170493617 @default.
• W2009055007 hasConceptScore W2009055007C199096232 @default.
• W2009055007 hasConceptScore W2009055007C207200792 @default.
• W2009055007 hasConceptScore W2009055007C2776553924 @default.
• W2009055007 hasConceptScore W2009055007C2778198053 @default.
• W2009055007 hasConceptScore W2009055007C2778797674 @default.
• W2009055007 hasConceptScore W2009055007C2778921608 @default.
• W2009055007 hasConceptScore W2009055007C2779178603 @default.
• W2009055007 hasConceptScore W2009055007C2779276759 @default.
• W2009055007 hasConceptScore W2009055007C2779280383 @default.
• W2009055007 hasConceptScore W2009055007C2779779143 @default.
• W2009055007 hasConceptScore W2009055007C555293320 @default.
• W2009055007 hasConceptScore W2009055007C71924100 @default.
• W2009055007 hasIssue "10" @default.
• W2009055007 hasLocation W20090550071 @default.
• W2009055007 hasLocation W20090550072 @default.

• next