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- W2009058225 abstract "One of the challenges of a total artificial heart (TAH) design is to allow each ventricle to have adequate outputs under various preloads and afterloads. Clinically, left ventricular output must exceed right ventricular output in order to prevent pulmonary congestion. In this paper, output of the right and left ventricles was measured following changes in RPM and pulse time setting in a new “STU Electrohydraulic Total Artificial Heart” having a centrally placed thin rotor that displaces fluid from right to left ventricles. The TAH was submerged in a bucket of water, allowing measurement of output without resistance. Inflow pressures were held constant at 16 cmH2O. At a systolic time setting of 0.5 seconds, increasing RPM from 1125 to 4075 resulted in an increase in left ventricular output from 800 to 3900 cc/min and right ventricular output from 760 to 3000 cc/min. When RPM was set at 2325, changing the systolic pulse time setting from 0.5 to 2 seconds had no net effect on left ventricular output and right ventricular output decreased by 250 cc/min. Increasing RPM also increased heart rate (44 to 62 beats/min). Changes in venous pressure and arterial resistance have marked effects on the cardiac output. At a constant systolic pulse time setting, increasing the RPM increased cardiac output in both the left and right ventricles, with left ventricular output always exceeding right ventricular output. Results confirmed that the “STU” TAH was designed such that left ventricular output is favored over right ventricular output. Responses to venous pressure and arterial resistance must be compensated for by changes in RPM." @default.
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- W2009058225 date "2000-03-01" @default.
- W2009058225 modified "2023-09-27" @default.
- W2009058225 title "Challenges in control of balanced cardiac output of a new electrohydraulic total artificial heart" @default.
- W2009058225 doi "https://doi.org/10.1097/00002480-200003000-00216" @default.
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