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- W2009059635 abstract "The signal-guided and sequential assembly of biomolecules onto patterned surfaces is demonstrated. Readily transmittable electric signals are used to guide spatially selective deposition of the pH-responsive polysaccharide, chitosan, and functionalized chitosan conjugates, by generating localized pH gradients. The nucleophilic primary amine groups of chitosan enable facile conjugation of proteins and nucleic acids by two approaches, one an enzymatic approach and the other a standard chemical modification, thus providing flexibility when sequentially assembling biomolecules in a spatially selective manner. Moreover, we developed an agarose gel biomask for the sequential assembly of single-stranded DNA and confirmed its functionality through nucleic acid hybridization assays." @default.
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- W2009059635 date "2005-02-11" @default.
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- W2009059635 title "Signal-Directed Sequential Assembly of Biomolecules on Patterned Surfaces" @default.
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- W2009059635 doi "https://doi.org/10.1021/la047529k" @default.
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