Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009060322> ?p ?o ?g. }
- W2009060322 endingPage "194" @default.
- W2009060322 startingPage "190" @default.
- W2009060322 abstract "The relative contribution of two neuronal surface proteases, plasmin and a protease with thrombin-like specificity, on NB2a/dl neuroblastoma migration and neuritogenesis were examined. Exogenous plasmin induced cell body rounding and increased cell migration, but did not prevent or reverse neurite outgrowth. Inhibition of endogenous plasmin by its specific inhibitor, aprotinin, suppressed migration but did not induce neuritogenesis. Removal or inhibition of the thrombin-like protease by serum deprivation or hirudin addition, respectively, induced neurite outgrowth, as shown in our previous studies, but did not suppress migration. By contrast, trypsin induced simultaneous cell rounding and neurite retraction. These findings indicated that plasmin may regulate cell migration, while the thrombin-like protease may regulate facets of neurite outgrowth. Although unable to induce de novo neuritogenesis, plasmin inhibition potentiated the otherwise transient neurites induced by simultaneous inhibition of the thrombin-like protease. Since cultured neuronal cells migrate primarily in the direction of newly elaborated neurites, this finding is interpreted to indicate that cessation of neuronal migration by plasmin inhibition enhances net neurite outgrowth by inhibition of the putative thrombin-like protease." @default.
- W2009060322 created "2016-06-24" @default.
- W2009060322 creator A5054090992 @default.
- W2009060322 creator A5059634441 @default.
- W2009060322 date "1992-07-28" @default.
- W2009060322 modified "2023-09-23" @default.
- W2009060322 title "Regulation of neuronal migration and neuritogenesis by distinct surface proteases Relative contribution of plasmin and a thrombin-like protease" @default.
- W2009060322 cites W1463270837 @default.
- W2009060322 cites W1486021067 @default.
- W2009060322 cites W168949879 @default.
- W2009060322 cites W1964752464 @default.
- W2009060322 cites W1972368230 @default.
- W2009060322 cites W1973178333 @default.
- W2009060322 cites W1978155434 @default.
- W2009060322 cites W1980150902 @default.
- W2009060322 cites W1981934523 @default.
- W2009060322 cites W1982604306 @default.
- W2009060322 cites W1983447138 @default.
- W2009060322 cites W1991337902 @default.
- W2009060322 cites W1991666516 @default.
- W2009060322 cites W1994480608 @default.
- W2009060322 cites W1996965743 @default.
- W2009060322 cites W2001911771 @default.
- W2009060322 cites W2009988210 @default.
- W2009060322 cites W2013750006 @default.
- W2009060322 cites W2016432377 @default.
- W2009060322 cites W2017530903 @default.
- W2009060322 cites W2022649582 @default.
- W2009060322 cites W2024782177 @default.
- W2009060322 cites W2032487787 @default.
- W2009060322 cites W2034299466 @default.
- W2009060322 cites W2037863585 @default.
- W2009060322 cites W2040048163 @default.
- W2009060322 cites W2040997641 @default.
- W2009060322 cites W2047384110 @default.
- W2009060322 cites W2050165531 @default.
- W2009060322 cites W2054381865 @default.
- W2009060322 cites W2065700798 @default.
- W2009060322 cites W2067310342 @default.
- W2009060322 cites W2069152555 @default.
- W2009060322 cites W2077283393 @default.
- W2009060322 cites W2083368047 @default.
- W2009060322 cites W2104886744 @default.
- W2009060322 cites W2118928946 @default.
- W2009060322 cites W2137900251 @default.
- W2009060322 cites W2162567095 @default.
- W2009060322 cites W2262230367 @default.
- W2009060322 cites W25094101 @default.
- W2009060322 doi "https://doi.org/10.1016/0014-5793(92)80765-9" @default.
- W2009060322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1386577" @default.
- W2009060322 hasPublicationYear "1992" @default.
- W2009060322 type Work @default.
- W2009060322 sameAs 2009060322 @default.
- W2009060322 citedByCount "19" @default.
- W2009060322 countsByYear W20090603222012 @default.
- W2009060322 crossrefType "journal-article" @default.
- W2009060322 hasAuthorship W2009060322A5054090992 @default.
- W2009060322 hasAuthorship W2009060322A5059634441 @default.
- W2009060322 hasBestOaLocation W20090603221 @default.
- W2009060322 hasConcept C113246987 @default.
- W2009060322 hasConcept C137738243 @default.
- W2009060322 hasConcept C1491633281 @default.
- W2009060322 hasConcept C181199279 @default.
- W2009060322 hasConcept C182220744 @default.
- W2009060322 hasConcept C185592680 @default.
- W2009060322 hasConcept C202751555 @default.
- W2009060322 hasConcept C203014093 @default.
- W2009060322 hasConcept C2775883766 @default.
- W2009060322 hasConcept C2776714187 @default.
- W2009060322 hasConcept C2777292125 @default.
- W2009060322 hasConcept C2778271848 @default.
- W2009060322 hasConcept C2781071845 @default.
- W2009060322 hasConcept C2781307694 @default.
- W2009060322 hasConcept C55493867 @default.
- W2009060322 hasConcept C86803240 @default.
- W2009060322 hasConcept C89560881 @default.
- W2009060322 hasConcept C95444343 @default.
- W2009060322 hasConceptScore W2009060322C113246987 @default.
- W2009060322 hasConceptScore W2009060322C137738243 @default.
- W2009060322 hasConceptScore W2009060322C1491633281 @default.
- W2009060322 hasConceptScore W2009060322C181199279 @default.
- W2009060322 hasConceptScore W2009060322C182220744 @default.
- W2009060322 hasConceptScore W2009060322C185592680 @default.
- W2009060322 hasConceptScore W2009060322C202751555 @default.
- W2009060322 hasConceptScore W2009060322C203014093 @default.
- W2009060322 hasConceptScore W2009060322C2775883766 @default.
- W2009060322 hasConceptScore W2009060322C2776714187 @default.
- W2009060322 hasConceptScore W2009060322C2777292125 @default.
- W2009060322 hasConceptScore W2009060322C2778271848 @default.
- W2009060322 hasConceptScore W2009060322C2781071845 @default.
- W2009060322 hasConceptScore W2009060322C2781307694 @default.
- W2009060322 hasConceptScore W2009060322C55493867 @default.
- W2009060322 hasConceptScore W2009060322C86803240 @default.
- W2009060322 hasConceptScore W2009060322C89560881 @default.
- W2009060322 hasConceptScore W2009060322C95444343 @default.
- W2009060322 hasIssue "2" @default.
- W2009060322 hasLocation W20090603221 @default.
- W2009060322 hasLocation W20090603222 @default.