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• W2009069752 abstract "Novel pyrimidine-5-carboxamide derivatives bearing a 3-chloro-4-methoxybenzylamino group at the 4-position were identified as potent and highly selective phosphodiesterase 5 inhibitors. Among them, we successfully found 10j (avanafil) which exhibited a potent relaxant effect on isolated rabbit cavernosum (EC30=2.1 nM) and a high isozyme selectivity." @default.
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• W2009069752 date "2014-12-01" @default.
• W2009069752 modified "2023-10-07" @default.
• W2009069752 title "The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor" @default.
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• W2009069752 doi "https://doi.org/10.1016/j.bmcl.2014.10.008" @default.
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