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- W2009071274 abstract "Abstract Capsaicin, the pungent extract of red chilli peppers, is widely used in experimental cough models. We report two cases in which repeated exposure to red peppers led to asthma. The first patient was a 69-year-old non-atopic man who had worked in a grocery shop where he was exposed to red peppers for 5 years. He was first seen complaining of dyspnea and rhinorrhea. On clinical examination, he was wheezing and had sibilant rhonchi. Spirometry revealed a reversible obstructive defect. A realistic provocation test with red peppers was positive. Assessment after medical treatment and a change in employment revealed significant clinical improvement. The second patient was a 40-year-old atopic woman with a 30-year history of allergic asthma, who presented to our hospital because her asthma had worsened. Medical history revealed chronic exposure to dry red pepper powder at home. Spirometry demonstrated a reversible obstructive defect. Clinical improvement occurred after medical treatment and avoidance of exposure to peppers in the first patient, allowing him to stop treatment within 18 months. However, the second patient's asthma was worse, in spite of definite avoidance of red peppers and continued medical treatment. Capsaicin stimulates unmyelinated slow C fibers of the sensory nervous system, inducing reflex cough and sneezing. Recurrent exposure to this substance may lead to neurogenic inflammation resulting in increase of airway responsiveness. It is therefore possible that prolonged exposure to capsaicin can induce asthma and/or worsen pre-existent asthma." @default.
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- W2009071274 date "2010-03-01" @default.
- W2009071274 modified "2023-10-01" @default.
- W2009071274 title "Long-term exposure to inhaled capsaicin: Can it induce or worsen asthma?" @default.
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- W2009071274 doi "https://doi.org/10.1016/j.reval.2009.06.004" @default.
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