Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009072203> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2009072203 endingPage "161" @default.
- W2009072203 startingPage "151" @default.
- W2009072203 abstract "Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5ades Arg' serves as the predominant chemotactic factor in complement activated serum. Both C5a and its des Arg74 derivative are capable of promoting directed cellular migration as well as lysosomal enzyme release. When neutrophil chemotaxis is assessed by an ‘under agarose methodology’, in the absence of extraneous human serum proteins. C5a is found to be some 10- to 30-fold more active than C5ades Arg Quantitatively similar results are obtained when each factor is assessed for its ability to promote secretion of azurophilic granular enzymes from cytochalasin B-treated neutrophils. The C5a structural analog C5a-(1–69), lacking five residues of the C-terminal portion of the parent molecule, and a synthetic pentapeptide l-methionyl-l-glutaminyl-l-leucylglycyl-l-arginine, which mimics the C-terminal linear sequence of C5a (Chenoweth et al., 1979a), are found to be devoid of biological activity when examined either-alone or in combination. These findings imply that the C-terminal portions of C5a contribute importantly to modulating ligand-receptor interactions on neutrophils. Based on these observations, a conceptual model of the interaction of human C5a with the neutrophil C5a receptor is proposed. We hypothesize that C5a possesses an internal ‘recognition’ site in addition to the ‘activation’ site contained in the C-terminal region of the molecule." @default.
- W2009072203 created "2016-06-24" @default.
- W2009072203 creator A5058259857 @default.
- W2009072203 creator A5073248837 @default.
- W2009072203 date "1980-02-01" @default.
- W2009072203 modified "2023-10-17" @default.
- W2009072203 title "Human C5a and C5a analogs as probes of the neutrophil C5a receptor" @default.
- W2009072203 cites W1482118367 @default.
- W2009072203 cites W1579863360 @default.
- W2009072203 cites W1775749144 @default.
- W2009072203 cites W1802069116 @default.
- W2009072203 cites W1964522162 @default.
- W2009072203 cites W1965809927 @default.
- W2009072203 cites W1981874508 @default.
- W2009072203 cites W1987577695 @default.
- W2009072203 cites W1996820575 @default.
- W2009072203 cites W2004882375 @default.
- W2009072203 cites W2017470279 @default.
- W2009072203 cites W2036994407 @default.
- W2009072203 cites W2041016331 @default.
- W2009072203 cites W2043403577 @default.
- W2009072203 cites W2086165385 @default.
- W2009072203 cites W2087791753 @default.
- W2009072203 cites W2090109532 @default.
- W2009072203 cites W2119221986 @default.
- W2009072203 cites W2126903130 @default.
- W2009072203 cites W2131233813 @default.
- W2009072203 cites W2138170739 @default.
- W2009072203 cites W2139403145 @default.
- W2009072203 cites W2263434320 @default.
- W2009072203 doi "https://doi.org/10.1016/0161-5890(80)90067-x" @default.
- W2009072203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6248769" @default.
- W2009072203 hasPublicationYear "1980" @default.
- W2009072203 type Work @default.
- W2009072203 sameAs 2009072203 @default.
- W2009072203 citedByCount "132" @default.
- W2009072203 countsByYear W20090722032012 @default.
- W2009072203 countsByYear W20090722032013 @default.
- W2009072203 countsByYear W20090722032014 @default.
- W2009072203 countsByYear W20090722032016 @default.
- W2009072203 countsByYear W20090722032017 @default.
- W2009072203 countsByYear W20090722032018 @default.
- W2009072203 countsByYear W20090722032021 @default.
- W2009072203 countsByYear W20090722032022 @default.
- W2009072203 crossrefType "journal-article" @default.
- W2009072203 hasAuthorship W2009072203A5058259857 @default.
- W2009072203 hasAuthorship W2009072203A5073248837 @default.
- W2009072203 hasConcept C111684460 @default.
- W2009072203 hasConcept C159654299 @default.
- W2009072203 hasConcept C170493617 @default.
- W2009072203 hasConcept C185592680 @default.
- W2009072203 hasConcept C203014093 @default.
- W2009072203 hasConcept C2779499704 @default.
- W2009072203 hasConcept C54166955 @default.
- W2009072203 hasConcept C55493867 @default.
- W2009072203 hasConcept C71318922 @default.
- W2009072203 hasConcept C86803240 @default.
- W2009072203 hasConcept C95444343 @default.
- W2009072203 hasConceptScore W2009072203C111684460 @default.
- W2009072203 hasConceptScore W2009072203C159654299 @default.
- W2009072203 hasConceptScore W2009072203C170493617 @default.
- W2009072203 hasConceptScore W2009072203C185592680 @default.
- W2009072203 hasConceptScore W2009072203C203014093 @default.
- W2009072203 hasConceptScore W2009072203C2779499704 @default.
- W2009072203 hasConceptScore W2009072203C54166955 @default.
- W2009072203 hasConceptScore W2009072203C55493867 @default.
- W2009072203 hasConceptScore W2009072203C71318922 @default.
- W2009072203 hasConceptScore W2009072203C86803240 @default.
- W2009072203 hasConceptScore W2009072203C95444343 @default.
- W2009072203 hasIssue "2" @default.
- W2009072203 hasLocation W20090722031 @default.
- W2009072203 hasLocation W20090722032 @default.
- W2009072203 hasOpenAccess W2009072203 @default.
- W2009072203 hasPrimaryLocation W20090722031 @default.
- W2009072203 hasRelatedWork W2024875771 @default.
- W2009072203 hasRelatedWork W2045322776 @default.
- W2009072203 hasRelatedWork W2053566730 @default.
- W2009072203 hasRelatedWork W2065760147 @default.
- W2009072203 hasRelatedWork W2106701275 @default.
- W2009072203 hasRelatedWork W2140994343 @default.
- W2009072203 hasRelatedWork W2161740020 @default.
- W2009072203 hasRelatedWork W2410961215 @default.
- W2009072203 hasRelatedWork W3017697131 @default.
- W2009072203 hasRelatedWork W4252629924 @default.
- W2009072203 hasVolume "17" @default.
- W2009072203 isParatext "false" @default.
- W2009072203 isRetracted "false" @default.
- W2009072203 magId "2009072203" @default.
- W2009072203 workType "article" @default.