Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009076537> ?p ?o ?g. }
- W2009076537 endingPage "590" @default.
- W2009076537 startingPage "579" @default.
- W2009076537 abstract "The product of the Scmh1 gene, a mammalian homolog of DrosophilaSex comb on midleg, is a constituent of the mammalian Polycomb repressive complexes 1 (Prc1). We have identified Scmh1 as an indispensable component of the Prc1. During progression through pachytene, Scmh1 was shown to be excluded from the XY body at late pachytene, together with other Prc1 components such as Phc1, Phc2, Rnf110 (Pcgf2), Bmi1 and Cbx2. We have identified the role of Scmh1 in mediating the survival of late pachytene spermatocytes. Apoptotic elimination of Scmh1-/- spermatocytes is accompanied by the preceding failure of several specific chromatin modifications at the XY body, whereas synapsis of homologous autosomes is not affected. It is therefore suggested that Scmh1 is involved in regulating the sequential changes in chromatin modifications at the XY chromatin domain of the pachytene spermatocytes. Restoration of defects in Scmh1-/-spermatocytes by Phc2 mutation indicates that Scmh1 exerts its molecular functions via its interaction with Prc1. Therefore, for the first time, we are able to indicate a functional involvement of Prc1 during the meiotic prophase of male germ cells and a regulatory role of Scmh1 for Prc1,which involves sex chromosomes." @default.
- W2009076537 created "2016-06-24" @default.
- W2009076537 creator A5009333872 @default.
- W2009076537 creator A5014632478 @default.
- W2009076537 creator A5018417608 @default.
- W2009076537 creator A5022881238 @default.
- W2009076537 creator A5026072466 @default.
- W2009076537 creator A5027603182 @default.
- W2009076537 creator A5031982146 @default.
- W2009076537 creator A5033304733 @default.
- W2009076537 creator A5033501880 @default.
- W2009076537 creator A5040681676 @default.
- W2009076537 creator A5064427269 @default.
- W2009076537 creator A5066057500 @default.
- W2009076537 date "2007-02-01" @default.
- W2009076537 modified "2023-10-03" @default.
- W2009076537 title "Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes" @default.
- W2009076537 cites W129013773 @default.
- W2009076537 cites W1481473039 @default.
- W2009076537 cites W1510180204 @default.
- W2009076537 cites W1577458365 @default.
- W2009076537 cites W1606401780 @default.
- W2009076537 cites W1865585336 @default.
- W2009076537 cites W1903601470 @default.
- W2009076537 cites W1968536052 @default.
- W2009076537 cites W1973886069 @default.
- W2009076537 cites W1979849229 @default.
- W2009076537 cites W1986531164 @default.
- W2009076537 cites W1987477108 @default.
- W2009076537 cites W1999228297 @default.
- W2009076537 cites W1999483579 @default.
- W2009076537 cites W2002698073 @default.
- W2009076537 cites W2009580999 @default.
- W2009076537 cites W2009877718 @default.
- W2009076537 cites W2011192730 @default.
- W2009076537 cites W2012598468 @default.
- W2009076537 cites W2013126973 @default.
- W2009076537 cites W2013832080 @default.
- W2009076537 cites W2015132841 @default.
- W2009076537 cites W2021334674 @default.
- W2009076537 cites W2021992179 @default.
- W2009076537 cites W2025075293 @default.
- W2009076537 cites W2028003321 @default.
- W2009076537 cites W2031655127 @default.
- W2009076537 cites W2033533217 @default.
- W2009076537 cites W2034459341 @default.
- W2009076537 cites W2037903941 @default.
- W2009076537 cites W2038548460 @default.
- W2009076537 cites W2045677887 @default.
- W2009076537 cites W2047772368 @default.
- W2009076537 cites W2051027941 @default.
- W2009076537 cites W2053101516 @default.
- W2009076537 cites W2053881125 @default.
- W2009076537 cites W2056225477 @default.
- W2009076537 cites W2058519503 @default.
- W2009076537 cites W2060870400 @default.
- W2009076537 cites W2074199894 @default.
- W2009076537 cites W2076030858 @default.
- W2009076537 cites W2078968652 @default.
- W2009076537 cites W2079291593 @default.
- W2009076537 cites W2087172939 @default.
- W2009076537 cites W2097727084 @default.
- W2009076537 cites W2103527620 @default.
- W2009076537 cites W2105704892 @default.
- W2009076537 cites W2108547322 @default.
- W2009076537 cites W2108554047 @default.
- W2009076537 cites W2121356384 @default.
- W2009076537 cites W2121437390 @default.
- W2009076537 cites W2122910069 @default.
- W2009076537 cites W2133400477 @default.
- W2009076537 cites W2135748193 @default.
- W2009076537 cites W2136570275 @default.
- W2009076537 cites W2142508948 @default.
- W2009076537 cites W2143817569 @default.
- W2009076537 cites W2144686577 @default.
- W2009076537 cites W2148598128 @default.
- W2009076537 cites W2153424791 @default.
- W2009076537 cites W2158610627 @default.
- W2009076537 cites W2161313400 @default.
- W2009076537 cites W2165894156 @default.
- W2009076537 cites W2168436056 @default.
- W2009076537 cites W2170373841 @default.
- W2009076537 doi "https://doi.org/10.1242/dev.02747" @default.
- W2009076537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17215307" @default.
- W2009076537 hasPublicationYear "2007" @default.
- W2009076537 type Work @default.
- W2009076537 sameAs 2009076537 @default.
- W2009076537 citedByCount "56" @default.
- W2009076537 countsByYear W20090765372012 @default.
- W2009076537 countsByYear W20090765372013 @default.
- W2009076537 countsByYear W20090765372014 @default.
- W2009076537 countsByYear W20090765372015 @default.
- W2009076537 countsByYear W20090765372016 @default.
- W2009076537 countsByYear W20090765372017 @default.
- W2009076537 countsByYear W20090765372018 @default.
- W2009076537 countsByYear W20090765372019 @default.
- W2009076537 countsByYear W20090765372020 @default.
- W2009076537 countsByYear W20090765372021 @default.