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- W2009076571 abstract "In the United States (US), prostate cancer (CaP) accounts for the largest percentage of new cancer cases (33%) and is the second leading cause of cancer death (10%) inmen. In2005, therewillbeanestimated232,090 new cases and 30,350 deaths from prostate cancer in our country [1]. Based upon cases diagnosed between 1992 and 1999, it is estimated that approximately 86% of these cases are local or regional at diagnosis. The incidence of distant stage disease began to decrease at a dramatic rate of 17.9% per year in 1991 in whites, and has been decreasing in other races as well. This represents a large difference in terms of treatment outcomes, considering that the 5-year survival rate is nearly 100% for local or regional disease, and only33.5%for distant stagedisease [1]. Furthermore, according to the US Surveillance, Epidemiology and End Results (SEER) program, the overall 5year relative survival rate for CaP was 75% from 1983 to 1985, and 99% from 1995 to 2000 – the greatest improvement for any tumor [2]. It is likely that screening is at least in part responsible for the trend toward decreasing prostate cancerspecific mortality in the US. Similar results occurred when PSA testing was made freely available in Tyrol, Austria [3]. The prostate cancer mortality declined at a significantly faster rate in Tyrol than in the remainder of Austria, where screening was then not as widely used. Despite these favorable trends, screening has continued to be the subject of heated controversy. In the" @default.
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- W2009076571 date "2005-10-01" @default.
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- W2009076571 title "The PSA Era is not Over for Prostate Cancer" @default.
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- W2009076571 doi "https://doi.org/10.1016/j.eururo.2005.07.014" @default.
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