FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009077193> ?p ?o ?g. }

• W2009077193 abstract "Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene occur in the majority of sporadic renal-cell carcinomas (RCC). Loss of VHL function is associated with stabilization of hypoxia-inducible factor α (HIFα). We and others demonstrated that there is a two-way interaction between the aryl hydrocarbon receptor, which is an important mediator in the metabolic activation and detoxification of carcinogens, and the HIF1-pathway leading to an increased genetic instability when both pathways are simultaneously activated. The aim of this study was to investigate how environmental carcinogens, such as benzo[a]pyrene (BaP), which can be metabolically activated to BaP-7,8-diOH-9,10-epoxide (BPDE) play a role in the etiology of renal-cell carcinomas (RCC). We exposed VHL deficient RCC4 cells, in which HIFα is stabilized regardless of oxygen tension, to 0.1&#181;M BaP for 18 hours. The mutagenic BPDE-DNA adduct levels were increased in HIFα stabilized cells. Using qRT-PCR, we demonstrated that absence of VHL significantly induced the mRNA levels of AhR downstream target CYP1A1. Furthermore, HPLC analysis indicated that loss of VHL increased the concentration of BaP-7,8-dihydroxydiol, the pre-cursor metabolite of BPDE. Interestingly, the capacity to repair BPDE-DNA adducts in the HIFα stabilized RCC4 cells, was markedly reduced. Taken together, these data indicate that loss of VHL affects BaP-mediated genotoxic responses in renal-cell carcinoma and decreases repair capacity." @default.
• W2009077193 created "2016-06-24" @default.
• W2009077193 creator A5011054210 @default.
• W2009077193 creator A5014817206 @default.
• W2009077193 creator A5060597026 @default.
• W2009077193 creator A5061638482 @default.
• W2009077193 creator A5085381106 @default.
• W2009077193 date "2013-01-01" @default.
• W2009077193 modified "2023-10-17" @default.
• W2009077193 title "Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene" @default.
• W2009077193 cites W1631673212 @default.
• W2009077193 cites W1749022239 @default.
• W2009077193 cites W1881840670 @default.
• W2009077193 cites W1971517620 @default.
• W2009077193 cites W1974642640 @default.
• W2009077193 cites W1982265633 @default.
• W2009077193 cites W1990607537 @default.
• W2009077193 cites W2000697685 @default.
• W2009077193 cites W2010394923 @default.
• W2009077193 cites W2016455125 @default.
• W2009077193 cites W2033713843 @default.
• W2009077193 cites W2080028418 @default.
• W2009077193 cites W2080374319 @default.
• W2009077193 cites W2085609942 @default.
• W2009077193 cites W2092406406 @default.
• W2009077193 cites W2092584460 @default.
• W2009077193 cites W2094242056 @default.
• W2009077193 cites W2098545354 @default.
• W2009077193 cites W2108211660 @default.
• W2009077193 cites W2128329009 @default.
• W2009077193 cites W2128442121 @default.
• W2009077193 cites W2130219349 @default.
• W2009077193 cites W2143013757 @default.
• W2009077193 cites W2144625075 @default.
• W2009077193 cites W2148162464 @default.
• W2009077193 cites W2149960175 @default.
• W2009077193 cites W2158734599 @default.
• W2009077193 cites W2160527903 @default.
• W2009077193 doi "https://doi.org/10.3389/fonc.2013.00270" @default.
• W2009077193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3809518" @default.
• W2009077193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24195061" @default.
• W2009077193 hasPublicationYear "2013" @default.
• W2009077193 type Work @default.
• W2009077193 sameAs 2009077193 @default.
• W2009077193 citedByCount "7" @default.
• W2009077193 countsByYear W20090771932015 @default.
• W2009077193 countsByYear W20090771932016 @default.
• W2009077193 countsByYear W20090771932017 @default.
• W2009077193 countsByYear W20090771932022 @default.
• W2009077193 countsByYear W20090771932023 @default.
• W2009077193 crossrefType "journal-article" @default.
• W2009077193 hasAuthorship W2009077193A5011054210 @default.
• W2009077193 hasAuthorship W2009077193A5014817206 @default.
• W2009077193 hasAuthorship W2009077193A5060597026 @default.
• W2009077193 hasAuthorship W2009077193A5061638482 @default.
• W2009077193 hasAuthorship W2009077193A5085381106 @default.
• W2009077193 hasBestOaLocation W20090771931 @default.
• W2009077193 hasConcept C104317684 @default.
• W2009077193 hasConcept C114246631 @default.
• W2009077193 hasConcept C134935766 @default.
• W2009077193 hasConcept C143425029 @default.
• W2009077193 hasConcept C153911025 @default.
• W2009077193 hasConcept C160450060 @default.
• W2009077193 hasConcept C185592680 @default.
• W2009077193 hasConcept C2777477808 @default.
• W2009077193 hasConcept C2777538855 @default.
• W2009077193 hasConcept C33594762 @default.
• W2009077193 hasConcept C502942594 @default.
• W2009077193 hasConcept C552990157 @default.
• W2009077193 hasConcept C55493867 @default.
• W2009077193 hasConcept C86339819 @default.
• W2009077193 hasConcept C86803240 @default.
• W2009077193 hasConceptScore W2009077193C104317684 @default.
• W2009077193 hasConceptScore W2009077193C114246631 @default.
• W2009077193 hasConceptScore W2009077193C134935766 @default.
• W2009077193 hasConceptScore W2009077193C143425029 @default.
• W2009077193 hasConceptScore W2009077193C153911025 @default.
• W2009077193 hasConceptScore W2009077193C160450060 @default.
• W2009077193 hasConceptScore W2009077193C185592680 @default.
• W2009077193 hasConceptScore W2009077193C2777477808 @default.
• W2009077193 hasConceptScore W2009077193C2777538855 @default.
• W2009077193 hasConceptScore W2009077193C33594762 @default.
• W2009077193 hasConceptScore W2009077193C502942594 @default.
• W2009077193 hasConceptScore W2009077193C552990157 @default.
• W2009077193 hasConceptScore W2009077193C55493867 @default.
• W2009077193 hasConceptScore W2009077193C86339819 @default.
• W2009077193 hasConceptScore W2009077193C86803240 @default.
• W2009077193 hasLocation W20090771931 @default.
• W2009077193 hasLocation W20090771932 @default.
• W2009077193 hasLocation W20090771933 @default.
• W2009077193 hasLocation W20090771934 @default.
• W2009077193 hasLocation W20090771935 @default.
• W2009077193 hasLocation W20090771936 @default.
• W2009077193 hasOpenAccess W2009077193 @default.
• W2009077193 hasPrimaryLocation W20090771931 @default.
• W2009077193 hasRelatedWork W1797836567 @default.
• W2009077193 hasRelatedWork W2004545781 @default.
• W2009077193 hasRelatedWork W2027110672 @default.
• W2009077193 hasRelatedWork W2059101420 @default.
• W2009077193 hasRelatedWork W2089719345 @default.

• next