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- W2009078449 abstract "NGF receptors were visualized in human brain sections with an immunohistochemical procedure using a monoclonal antibody. This method results in the selective visualization of a population of neurons in the medial septal nucleus, the nucleus of the diagonal band of Broca, and the nucleus basalis of Meynert. Several lines of evidence indicate that this neuronal population is identical to the cholinergic neurons of the basal forebrain. NGF receptor immunohistochemistry therefore represents a sensitive and reliable procedure to selectively visualize forebrain cholinergic neurons for post-mortem analysis. NGF receptors were found to be expressed during the entire life span. However, the intracellular staining intensity was reduced in normal aging, suggesting the tentative conclusion that NGF receptor synthesis may decline in the aged brain. In Alzheimer's disease, the number of NGF receptor-positive cells was decreased. The morphological characteristics of surviving neurons were similar to immuno-positive neurons visualized in normal aged brains." @default.
- W2009078449 created "2016-06-24" @default.
- W2009078449 creator A5054270816 @default.
- W2009078449 creator A5084723460 @default.
- W2009078449 date "1989-01-01" @default.
- W2009078449 modified "2023-10-09" @default.
- W2009078449 title "Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease" @default.
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- W2009078449 doi "https://doi.org/10.1016/s0197-4580(89)80014-4" @default.
- W2009078449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2547172" @default.
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