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• W2009078553 abstract "ABSTRACT Mutants of attenuated Bacillus anthracis with high-level ciprofloxacin resistance were isolated using a three-step in vitro selection. Ciprofloxacin MICs were 0.5 μg/ml for first-step mutants, which had one of two gyrA quinolone resistance-determining region (QRDR) mutations. Ciprofloxacin MICs were 8 and 16 μg/ml for second-step mutants, which had one of three parC QRDR mutations. Ciprofloxacin MICs for third-step mutants were 32 and 64 μg/ml. Mutants for which MICs were 64 μg/ml had one of two additional mutations within the gyrA QRDR or one of two mutations within the gyrB QRDR. Mutants for which MICs were 32 μg/ml had no additional target modifications but showed evidence of enhanced ciprofloxacin efflux." @default.
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• W2009078553 date "2003-07-01" @default.
• W2009078553 modified "2023-10-18" @default.
• W2009078553 title "In Vitro Selection and Characterization of <i>Bacillus anthracis</i> Mutants with High-Level Resistance to Ciprofloxacin" @default.
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• W2009078553 doi "https://doi.org/10.1128/aac.47.7.2362-2365.2003" @default.
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