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- W2009091461 abstract "While agent host-range and strain properties convinced early researchers of a viral etiology, the once unorthodox postulate that prion transmission occurs by conformational corruption of host-encoded cellular prion protein (PrPC) by a pathogenic isoform (PrPSc) is now widely accepted. Indeed, conformational templating is increasingly understood to be a general mechanism of protein-mediated information transfer and pathogenesis. The high infectivity of prions, their capacity to cause neurodegeneration in genetically tractable animal models, as well as the ability to culture prions in cells, or under cell-free conditions using defined components, provide finely controlled experimental settings in which to elucidate general mechanisms for all diseases involving protein conformational templating, and thus to develop integrated therapeutic approaches." @default.
- W2009091461 created "2016-06-24" @default.
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- W2009091461 date "2013-01-31" @default.
- W2009091461 modified "2023-09-27" @default.
- W2009091461 title "The Importance of Prions" @default.
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- W2009091461 doi "https://doi.org/10.1371/journal.ppat.1003090" @default.
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