Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009093003> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2009093003 abstract "To clarify the interaction between endothelin-1 (ET-1) and atrial natriuretic peptide (ANP), the effects of ET-1 on ANP secretion were investigated in isolated perfused rat hearts and in conscious unrestrained rats. Perfusion with 10(-9) M ET-1 stimulated ANP secretion from the isolated perfused rat heart. However, 10(-10) M ET-1 significantly decreased ANP secretion for the initial 15 min of the perfusion period. The perfusion with 10(-11) M ET-1, which is near the plasma level of ET-1 (2 x 10(-12) M), inhibited ANP secretion throughout the perfusion period. The perfusion of 10(-12) M ET-1 slightly decreased ANP secretion. After the ET-1 perfusion period, ANP secretion increased in proportion to ET-1 dose. The inhibitory action of ET-1 on ANP secretion was almost abolished by simultaneous perfusion of indomethacin, a cyclooxygenase inhibitor, but not by methylene blue, an inhibitor of soluble guanylate cyclase. In conscious unrestrained rats the iv infusion of 1 pmol/kg.min ET-1, which doubled the plasma ET-1 level, slightly but significantly decreased the plasma ANP level 5 and 10 min after the initiation of the infusion. The infusion of 10 and 30 pmol/kg.min ET-1 increased the plasma ANP level. These results demonstrate that low doses of ET-1 exert an inhibitory and short-acting action on ANP secretion from the heart, although high doses of ET-1 exert stimulating and long-lasting action, and suggest that prostanoids are involved in this inhibitory action." @default.
- W2009093003 created "2016-06-24" @default.
- W2009093003 creator A5012591536 @default.
- W2009093003 creator A5030772606 @default.
- W2009093003 creator A5031073276 @default.
- W2009093003 creator A5033980070 @default.
- W2009093003 creator A5047143180 @default.
- W2009093003 creator A5048368425 @default.
- W2009093003 creator A5066956159 @default.
- W2009093003 creator A5079710697 @default.
- W2009093003 creator A5079957907 @default.
- W2009093003 creator A5080742828 @default.
- W2009093003 date "1993-05-01" @default.
- W2009093003 modified "2023-09-28" @default.
- W2009093003 title "Low doses of endothelin-1 inhibit atrial natriuretic peptide secretion." @default.
- W2009093003 cites W1978927149 @default.
- W2009093003 cites W1995298150 @default.
- W2009093003 cites W2000309355 @default.
- W2009093003 cites W2005385625 @default.
- W2009093003 cites W2009415859 @default.
- W2009093003 cites W2018651370 @default.
- W2009093003 cites W2020062617 @default.
- W2009093003 cites W2027804316 @default.
- W2009093003 cites W2059369537 @default.
- W2009093003 cites W2063335892 @default.
- W2009093003 cites W2090072334 @default.
- W2009093003 cites W2116536722 @default.
- W2009093003 cites W2122271654 @default.
- W2009093003 cites W2125117566 @default.
- W2009093003 cites W2131083572 @default.
- W2009093003 cites W2162804111 @default.
- W2009093003 cites W2229805503 @default.
- W2009093003 cites W2283638085 @default.
- W2009093003 cites W2607123809 @default.
- W2009093003 doi "https://doi.org/10.1210/endo.132.5.8477643" @default.
- W2009093003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8477643" @default.
- W2009093003 hasPublicationYear "1993" @default.
- W2009093003 type Work @default.
- W2009093003 sameAs 2009093003 @default.
- W2009093003 citedByCount "13" @default.
- W2009093003 countsByYear W20090930032014 @default.
- W2009093003 countsByYear W20090930032020 @default.
- W2009093003 crossrefType "journal-article" @default.
- W2009093003 hasAuthorship W2009093003A5012591536 @default.
- W2009093003 hasAuthorship W2009093003A5030772606 @default.
- W2009093003 hasAuthorship W2009093003A5031073276 @default.
- W2009093003 hasAuthorship W2009093003A5033980070 @default.
- W2009093003 hasAuthorship W2009093003A5047143180 @default.
- W2009093003 hasAuthorship W2009093003A5048368425 @default.
- W2009093003 hasAuthorship W2009093003A5066956159 @default.
- W2009093003 hasAuthorship W2009093003A5079710697 @default.
- W2009093003 hasAuthorship W2009093003A5079957907 @default.
- W2009093003 hasAuthorship W2009093003A5080742828 @default.
- W2009093003 hasConcept C126322002 @default.
- W2009093003 hasConcept C134018914 @default.
- W2009093003 hasConcept C144980905 @default.
- W2009093003 hasConcept C146957229 @default.
- W2009093003 hasConcept C149601957 @default.
- W2009093003 hasConcept C170493617 @default.
- W2009093003 hasConcept C185592680 @default.
- W2009093003 hasConcept C2778069365 @default.
- W2009093003 hasConcept C49039625 @default.
- W2009093003 hasConcept C56191518 @default.
- W2009093003 hasConcept C71924100 @default.
- W2009093003 hasConceptScore W2009093003C126322002 @default.
- W2009093003 hasConceptScore W2009093003C134018914 @default.
- W2009093003 hasConceptScore W2009093003C144980905 @default.
- W2009093003 hasConceptScore W2009093003C146957229 @default.
- W2009093003 hasConceptScore W2009093003C149601957 @default.
- W2009093003 hasConceptScore W2009093003C170493617 @default.
- W2009093003 hasConceptScore W2009093003C185592680 @default.
- W2009093003 hasConceptScore W2009093003C2778069365 @default.
- W2009093003 hasConceptScore W2009093003C49039625 @default.
- W2009093003 hasConceptScore W2009093003C56191518 @default.
- W2009093003 hasConceptScore W2009093003C71924100 @default.
- W2009093003 hasLocation W20090930031 @default.
- W2009093003 hasLocation W20090930032 @default.
- W2009093003 hasOpenAccess W2009093003 @default.
- W2009093003 hasPrimaryLocation W20090930031 @default.
- W2009093003 hasRelatedWork W1980523564 @default.
- W2009093003 hasRelatedWork W1983371938 @default.
- W2009093003 hasRelatedWork W1997169304 @default.
- W2009093003 hasRelatedWork W2009093003 @default.
- W2009093003 hasRelatedWork W2074235845 @default.
- W2009093003 hasRelatedWork W2160355439 @default.
- W2009093003 hasRelatedWork W2237110052 @default.
- W2009093003 hasRelatedWork W2414102440 @default.
- W2009093003 hasRelatedWork W4247907296 @default.
- W2009093003 hasRelatedWork W4253373032 @default.
- W2009093003 isParatext "false" @default.
- W2009093003 isRetracted "false" @default.
- W2009093003 magId "2009093003" @default.
- W2009093003 workType "article" @default.