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- W2009093983 abstract "The role of androgens and androgen receptors (AR) in the pathophysiology of acne vulgaris appears to be a complex phenomenon. It has been suggested earlier that oral administration of isotretinoin, the drug of choice for severe cases of acne, exerts its action through ARs, which is quite debatable. The aim is to study the response of androgen receptor (AR) in the skin of acne vulgaris patients by administrating isotretinoin orally. Skin biopsy was procured from untreated patients of severe cases of acne vulgaris. Out of these, twenty histopathologically confirmed patients were included in the study. They were treated with oral isotretinoin in the dose of 0.5 mg/kg/day for 12 weeks, following which their skin biopsies were repeated. Immunostaining for androgen receptor was performed using mouse monoclonal antibodies. Androgen receptor index (AR index) was calculated for the acne patients before and following treatment with oral isotretinoin. Statistical analysis was done using paired t-test. The AR indices in skin of untreated acne patients were higher in male patients (26.62 ± 20.74) as compared to the female patients (7.5 ± 10.61). AR indices after 12 weeks of oral isotretinoin treatment showed a reduction in both males and female patients (20.55 ± 16 and 4.71 ± 6.75 respectively). However, the post treatment reduction in AR index was statistically significant in male patients only. Determination of AR status can be helpful in planning the treatment methodology of severe cases of acne. Our study also implicates the effectiveness of oral isotretinoin on acne patients through its interaction with androgen receptor." @default.
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- W2009093983 date "2015-06-01" @default.
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- W2009093983 title "Epidermal androgen receptors in acne vulgaris patients before and following oral isotretinoin" @default.
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- W2009093983 doi "https://doi.org/10.1016/j.jasi.2015.04.002" @default.
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