Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009094504> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2009094504 abstract "This is a response to a letter by Hu et al. (1)As Hu et al. pointed out (1), caspase-3 could process Mcl-1 during apoptosis, depending on the type of apoptotic stimuli or cell (2, 3). However, we did not detect any Mcl-1 fragments by immunoblotting during apoptosis in myoblast cells after induction by ATF6, WBP1, or endoplasmic reticulum (ER) stressors. We thus examined whether active ATF6 could reduce Mcl-1 levels in the absence of caspase activation. These conditions were established by overexpressing Bcl-xL. Again, Mcl-1 was reduced by active ATF6. Our conclusion is consistent with the current consensus that the level of the Mcl-1 protein is principally regulated by the ubiquitin/deubiquitin system. The cleavage of Mcl-1 by caspases during apoptosis may contribute to the feed-forward amplification of apoptotic signals after caspase activation (4). It is likely that, in myoblast cells, the completion of apoptosis does not depend on this feed-forward mechanism. We did not detect up-regulation of Mcl-1, Noxa, or Bim by DNA microarray analysis or quantitative PCR.A significant point of the study is that the unfolded protein response is linked to the Bcl-2 family during ER stress-induced apoptosis. Because expression of Bcl-2 family members can differ greatly among cell types (e.g. normal versus cancer cells), and complex interactions occur within the Bcl-2 family, Bcl-2 family proteins may respond to ER stress differently in different cell types. This would generate apparent discrepancies among studies. Nevertheless, these discrepancies may provide valuable clues for clinical applications (5)." @default.
- W2009094504 created "2016-06-24" @default.
- W2009094504 creator A5069249615 @default.
- W2009094504 creator A5070636104 @default.
- W2009094504 creator A5073243799 @default.
- W2009094504 date "2011-11-01" @default.
- W2009094504 modified "2023-10-04" @default.
- W2009094504 title "Reply to Hu et al.: Mcl-1 Reduction Due to Caspase-dependent Cleavage during Endoplasmic Reticulum Stress-induced Apoptosis" @default.
- W2009094504 cites W1991249033 @default.
- W2009094504 cites W2009486785 @default.
- W2009094504 cites W2048509801 @default.
- W2009094504 cites W2062547838 @default.
- W2009094504 cites W2121622734 @default.
- W2009094504 doi "https://doi.org/10.1074/jbc.n111.233502" @default.
- W2009094504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3207465" @default.
- W2009094504 hasPublicationYear "2011" @default.
- W2009094504 type Work @default.
- W2009094504 sameAs 2009094504 @default.
- W2009094504 citedByCount "0" @default.
- W2009094504 crossrefType "journal-article" @default.
- W2009094504 hasAuthorship W2009094504A5069249615 @default.
- W2009094504 hasAuthorship W2009094504A5070636104 @default.
- W2009094504 hasAuthorship W2009094504A5073243799 @default.
- W2009094504 hasBestOaLocation W20090945041 @default.
- W2009094504 hasConcept C12519072 @default.
- W2009094504 hasConcept C139447449 @default.
- W2009094504 hasConcept C151730666 @default.
- W2009094504 hasConcept C153911025 @default.
- W2009094504 hasConcept C158617107 @default.
- W2009094504 hasConcept C175156509 @default.
- W2009094504 hasConcept C185592680 @default.
- W2009094504 hasConcept C190283241 @default.
- W2009094504 hasConcept C2778997996 @default.
- W2009094504 hasConcept C2780292996 @default.
- W2009094504 hasConcept C31573885 @default.
- W2009094504 hasConcept C43369102 @default.
- W2009094504 hasConcept C55493867 @default.
- W2009094504 hasConcept C86803240 @default.
- W2009094504 hasConcept C95444343 @default.
- W2009094504 hasConcept C98424977 @default.
- W2009094504 hasConceptScore W2009094504C12519072 @default.
- W2009094504 hasConceptScore W2009094504C139447449 @default.
- W2009094504 hasConceptScore W2009094504C151730666 @default.
- W2009094504 hasConceptScore W2009094504C153911025 @default.
- W2009094504 hasConceptScore W2009094504C158617107 @default.
- W2009094504 hasConceptScore W2009094504C175156509 @default.
- W2009094504 hasConceptScore W2009094504C185592680 @default.
- W2009094504 hasConceptScore W2009094504C190283241 @default.
- W2009094504 hasConceptScore W2009094504C2778997996 @default.
- W2009094504 hasConceptScore W2009094504C2780292996 @default.
- W2009094504 hasConceptScore W2009094504C31573885 @default.
- W2009094504 hasConceptScore W2009094504C43369102 @default.
- W2009094504 hasConceptScore W2009094504C55493867 @default.
- W2009094504 hasConceptScore W2009094504C86803240 @default.
- W2009094504 hasConceptScore W2009094504C95444343 @default.
- W2009094504 hasConceptScore W2009094504C98424977 @default.
- W2009094504 hasLocation W20090945041 @default.
- W2009094504 hasLocation W20090945042 @default.
- W2009094504 hasOpenAccess W2009094504 @default.
- W2009094504 hasPrimaryLocation W20090945041 @default.
- W2009094504 hasRelatedWork W1511157412 @default.
- W2009094504 hasRelatedWork W1792716459 @default.
- W2009094504 hasRelatedWork W1862346079 @default.
- W2009094504 hasRelatedWork W1872816942 @default.
- W2009094504 hasRelatedWork W1992713548 @default.
- W2009094504 hasRelatedWork W1994510756 @default.
- W2009094504 hasRelatedWork W2001087530 @default.
- W2009094504 hasRelatedWork W2002807539 @default.
- W2009094504 hasRelatedWork W2007733499 @default.
- W2009094504 hasRelatedWork W2032412054 @default.
- W2009094504 hasRelatedWork W2051841458 @default.
- W2009094504 hasRelatedWork W2054033084 @default.
- W2009094504 hasRelatedWork W2054897703 @default.
- W2009094504 hasRelatedWork W2055265404 @default.
- W2009094504 hasRelatedWork W2059174972 @default.
- W2009094504 hasRelatedWork W2078445542 @default.
- W2009094504 hasRelatedWork W222841949 @default.
- W2009094504 hasRelatedWork W2993321467 @default.
- W2009094504 hasRelatedWork W3200652196 @default.
- W2009094504 hasRelatedWork W42062634 @default.
- W2009094504 isParatext "false" @default.
- W2009094504 isRetracted "false" @default.
- W2009094504 magId "2009094504" @default.
- W2009094504 workType "article" @default.