FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009094757> ?p ?o ?g. }

• W2009094757 abstract "Signals from several receptor tyrosine kinases are transduced by activation of the Ras family of GTP-binding proteins. Activation of Ras initiates a kinase cascade that culminates in activation of the mitogen-activated protein kinases (MAPKs). The MAPKs include the c-jun NH(2)-terminal protein kinases (JNKs) and extracellular signal-regulated kinases (ERKs), both of which phosphorylate Elk-1/TCF, a factor that activates transcription of the c-fos gene. In this report, we identify a novel 19 kDa gene product as a negative regulator of signaling through the ERK1/2 pathway. While these studies were in progress, the human homologue of this gene was characterized as diphosphoinositol polyphosphate phosphohydrolase (DIPP1) [EMBO J. 17 (1998) 6599], a phosphohydrolase that converts diphosphate groups on diphosphoinositol polyphosphates to monophosphates. Ectopic expression of murine DIPP1 (muDIPP1) blocked activation of the c-fos promoter by the ERK1/2 pathway. Inhibition of signal transduction through the ERK1/2 pathway by muDIPP1 occurs at or downstream from activation of MEK. In vitro kinase studies suggest that muDIPP1 is not a direct inhibitor of MEK or ERK activity, although, ectopic expression at near physiological levels results in attenuation of ERK phosphorylation in vivo. Interestingly, a site mutant of muDIPP1 lacking phosphohydrolase activity blocked signaling through the ERK1/2 pathway with greater efficiency than wild-type muDIPP1. This result suggests that inhibition of signaling through the ERK1/2 pathway is a distinct function of muDIPP1 that is not dependent on, but may be regulated by, its activity as a phosphohydrolase." @default.
• W2009094757 created "2016-06-24" @default.
• W2009094757 creator A5013107971 @default.
• W2009094757 creator A5016681558 @default.
• W2009094757 creator A5045986011 @default.
• W2009094757 creator A5047163650 @default.
• W2009094757 creator A5059696040 @default.
• W2009094757 creator A5070490588 @default.
• W2009094757 creator A5071141538 @default.
• W2009094757 creator A5079003235 @default.
• W2009094757 date "2004-09-01" @default.
• W2009094757 modified "2023-09-28" @default.
• W2009094757 title "Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway" @default.
• W2009094757 cites W1494401713 @default.
• W2009094757 cites W1508214573 @default.
• W2009094757 cites W1558506222 @default.
• W2009094757 cites W1597274086 @default.
• W2009094757 cites W1789455264 @default.
• W2009094757 cites W1796948519 @default.
• W2009094757 cites W1819159746 @default.
• W2009094757 cites W1879047317 @default.
• W2009094757 cites W1888156959 @default.
• W2009094757 cites W1908953867 @default.
• W2009094757 cites W1951853856 @default.
• W2009094757 cites W1966812211 @default.
• W2009094757 cites W1971013842 @default.
• W2009094757 cites W1971517152 @default.
• W2009094757 cites W1979027806 @default.
• W2009094757 cites W1989480480 @default.
• W2009094757 cites W1992864103 @default.
• W2009094757 cites W1993651324 @default.
• W2009094757 cites W1995819749 @default.
• W2009094757 cites W1997218197 @default.
• W2009094757 cites W1998143976 @default.
• W2009094757 cites W2000082154 @default.
• W2009094757 cites W2002282120 @default.
• W2009094757 cites W2007745785 @default.
• W2009094757 cites W2009338295 @default.
• W2009094757 cites W2009484032 @default.
• W2009094757 cites W2010955929 @default.
• W2009094757 cites W2011804819 @default.
• W2009094757 cites W2021628061 @default.
• W2009094757 cites W2025610870 @default.
• W2009094757 cites W2032671506 @default.
• W2009094757 cites W2034502645 @default.
• W2009094757 cites W2040470395 @default.
• W2009094757 cites W2040590580 @default.
• W2009094757 cites W2042127371 @default.
• W2009094757 cites W2044924820 @default.
• W2009094757 cites W2046968871 @default.
• W2009094757 cites W2050917648 @default.
• W2009094757 cites W2057513340 @default.
• W2009094757 cites W2060416249 @default.
• W2009094757 cites W2062706311 @default.
• W2009094757 cites W2063178731 @default.
• W2009094757 cites W2066696278 @default.
• W2009094757 cites W2067524077 @default.
• W2009094757 cites W2068032848 @default.
• W2009094757 cites W2068446924 @default.
• W2009094757 cites W2069785923 @default.
• W2009094757 cites W2070023258 @default.
• W2009094757 cites W2075517727 @default.
• W2009094757 cites W2080209900 @default.
• W2009094757 cites W2087521687 @default.
• W2009094757 cites W2089112795 @default.
• W2009094757 cites W2089741493 @default.
• W2009094757 cites W2089889881 @default.
• W2009094757 cites W2095152292 @default.
• W2009094757 cites W2096620350 @default.
• W2009094757 cites W2100974630 @default.
• W2009094757 cites W2102769899 @default.
• W2009094757 cites W2104550693 @default.
• W2009094757 cites W2126076915 @default.
• W2009094757 cites W2127227377 @default.
• W2009094757 cites W2127764420 @default.
• W2009094757 cites W2131968097 @default.
• W2009094757 cites W2144206181 @default.
• W2009094757 cites W2144634347 @default.
• W2009094757 cites W2162322742 @default.
• W2009094757 cites W2165914529 @default.
• W2009094757 cites W2330457575 @default.
• W2009094757 cites W2396028691 @default.
• W2009094757 cites W2406060777 @default.
• W2009094757 cites W248588628 @default.
• W2009094757 doi "https://doi.org/10.1016/j.cellsig.2004.02.009" @default.
• W2009094757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15212765" @default.
• W2009094757 hasPublicationYear "2004" @default.
• W2009094757 type Work @default.
• W2009094757 sameAs 2009094757 @default.
• W2009094757 citedByCount "14" @default.
• W2009094757 countsByYear W20090947572012 @default.
• W2009094757 countsByYear W20090947572013 @default.
• W2009094757 countsByYear W20090947572014 @default.
• W2009094757 countsByYear W20090947572017 @default.
• W2009094757 crossrefType "journal-article" @default.
• W2009094757 hasAuthorship W2009094757A5013107971 @default.
• W2009094757 hasAuthorship W2009094757A5016681558 @default.
• W2009094757 hasAuthorship W2009094757A5045986011 @default.
• W2009094757 hasAuthorship W2009094757A5047163650 @default.
• W2009094757 hasAuthorship W2009094757A5059696040 @default.

• next