Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009096907> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2009096907 endingPage "966" @default.
- W2009096907 startingPage "961" @default.
- W2009096907 abstract "In order to investigate the mechanisms leading to respiratory depression after lumbar administration of opioids, plasma and ventricular CSF pharmacokinetics of intrathecal meperidine (1 mg.kg-1) were studied in five head-injured patients undergoing surgery for lower limb fracture. Meperidine was detected both in the plasma (arterial catheter) and in the ventricular CSF (intracranial catheter) soon after intrathecal administration: 45 +/- 17 min and 100 +/- 14 min, respectively. The maximal plasma concentration was 341 +/- 133 ng.ml-1, whereas, in ventricular CSF, it was 64.5 +/- 14.9 ng.ml-1. The ventricular CSF-plasma ratio increased with time (r = 0.82) from 0.18 +/- 0.04 at the first hour to 0.38 +/- 0.1 at 16th hour. It is concluded that the putative risk of respiratory depression appears to be mainly related to the absorption into the systemic circulation and to redistribution back into CSF." @default.
- W2009096907 created "2016-06-24" @default.
- W2009096907 creator A5001665374 @default.
- W2009096907 creator A5004076250 @default.
- W2009096907 creator A5034293708 @default.
- W2009096907 creator A5089440657 @default.
- W2009096907 date "1989-06-01" @default.
- W2009096907 modified "2023-09-26" @default.
- W2009096907 title "Arterial and Ventricular CSF Pharmacokinetics after Intrathecal Meperidine in Humans" @default.
- W2009096907 doi "https://doi.org/10.1097/00000542-198906000-00013" @default.
- W2009096907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2729638" @default.
- W2009096907 hasPublicationYear "1989" @default.
- W2009096907 type Work @default.
- W2009096907 sameAs 2009096907 @default.
- W2009096907 citedByCount "22" @default.
- W2009096907 countsByYear W20090969072012 @default.
- W2009096907 crossrefType "journal-article" @default.
- W2009096907 hasAuthorship W2009096907A5001665374 @default.
- W2009096907 hasAuthorship W2009096907A5004076250 @default.
- W2009096907 hasAuthorship W2009096907A5034293708 @default.
- W2009096907 hasAuthorship W2009096907A5089440657 @default.
- W2009096907 hasBestOaLocation W20090969071 @default.
- W2009096907 hasConcept C112705442 @default.
- W2009096907 hasConcept C126322002 @default.
- W2009096907 hasConcept C139719470 @default.
- W2009096907 hasConcept C141071460 @default.
- W2009096907 hasConcept C157820659 @default.
- W2009096907 hasConcept C162324750 @default.
- W2009096907 hasConcept C2776867660 @default.
- W2009096907 hasConcept C2779651940 @default.
- W2009096907 hasConcept C42219234 @default.
- W2009096907 hasConcept C44575665 @default.
- W2009096907 hasConcept C534529494 @default.
- W2009096907 hasConcept C71924100 @default.
- W2009096907 hasConceptScore W2009096907C112705442 @default.
- W2009096907 hasConceptScore W2009096907C126322002 @default.
- W2009096907 hasConceptScore W2009096907C139719470 @default.
- W2009096907 hasConceptScore W2009096907C141071460 @default.
- W2009096907 hasConceptScore W2009096907C157820659 @default.
- W2009096907 hasConceptScore W2009096907C162324750 @default.
- W2009096907 hasConceptScore W2009096907C2776867660 @default.
- W2009096907 hasConceptScore W2009096907C2779651940 @default.
- W2009096907 hasConceptScore W2009096907C42219234 @default.
- W2009096907 hasConceptScore W2009096907C44575665 @default.
- W2009096907 hasConceptScore W2009096907C534529494 @default.
- W2009096907 hasConceptScore W2009096907C71924100 @default.
- W2009096907 hasIssue "6" @default.
- W2009096907 hasLocation W20090969071 @default.
- W2009096907 hasLocation W20090969072 @default.
- W2009096907 hasOpenAccess W2009096907 @default.
- W2009096907 hasPrimaryLocation W20090969071 @default.
- W2009096907 hasRelatedWork W2016754540 @default.
- W2009096907 hasRelatedWork W2113860368 @default.
- W2009096907 hasRelatedWork W2146931206 @default.
- W2009096907 hasRelatedWork W2160367005 @default.
- W2009096907 hasRelatedWork W2375811759 @default.
- W2009096907 hasRelatedWork W2399325594 @default.
- W2009096907 hasRelatedWork W2403553665 @default.
- W2009096907 hasRelatedWork W4234582764 @default.
- W2009096907 hasRelatedWork W4245556114 @default.
- W2009096907 hasRelatedWork W46351005 @default.
- W2009096907 hasVolume "70" @default.
- W2009096907 isParatext "false" @default.
- W2009096907 isRetracted "false" @default.
- W2009096907 magId "2009096907" @default.
- W2009096907 workType "article" @default.