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• W2009097974 abstract "To better understand the maturational stages during T-cell development, we studied the expression of CD3δ and CD3ϵ genes, as well as the presence of TCR gene rearrangements, within CD3−CD16+ NK clones derived from thymic precursors in vitro. Northern blot analysis revealed that CD3−CD16+ clones derived from CD7+ CD3−CD4−CD8− (TN) thymocytes expressed transcripts for the CD3ϵ gene; however, no transcripts for the CD38 gene were detected. Importantly, both the CD3ϵ and CD3δ genes were expressed in TN thymocytes examined prior to cloning. A CD7+CD8+CD3−CD4− thymocyte population that makes up only 0.4% of the total thymocyte pool was also isolated from human thymus. We determined the maturation potential of this CD7+ CDS+ CD3−CD4− population by limiting dilution cloning and found that 67% of the clones generated in vitro had a CD3−CD16+ CD8+ phenotype. In contrast to the NK clones derived from TN precursors, most CD3−CD16+ clones derived from CD7+ CD8+ CD3−CD4− thymocytes expressed transcripts for both CD3ϵ and CD3δ genes. Southern blot analysis of the NK clones derived from either thymic precursor population revealed no rearrangement of the TCR β or γ genes. These results demonstrate that the TN progenitor population and their CD3−CD16+ progeny differ in their expression of the CD38 transcript and during in vitro culture there is loss of CD38 expression and acquisition of surface CD16 within these NK clones. Furthermore, the CD3−CD16+ clones derived from TN versus CD7+ CD8+CD3−CD4− thymocytes differed in their expression of the CD38 gene. The signaling events regulating the expression of the CD3 invariant chain genes within immature lymphoid progenitor cells may be important in determining their eventual maturation into T-cell and NK-cell lineages in vivo." @default.
• W2009097974 created "2016-06-24" @default.
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• W2009097974 date "1995-08-01" @default.
• W2009097974 modified "2023-09-27" @default.
• W2009097974 title "CD3 δ and ϵ gene expression in CD3t-CD16+ natural killer cell clones derived from thymic precursors" @default.
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• W2009097974 doi "https://doi.org/10.1016/0198-8859(95)91034-u" @default.
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