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- W2009105760 abstract "Questions Neural plasticity involves reorganization of synaptic connections and represents the brain’s capacity to reorganize its function in response to a challenge or to a stimulus. Plasticity implies changing synaptic activity and connectivity and the underlying mechanisms are long-term potentiation (LTP) and long-term depression (LTD). Methods In four studies, using excitability-enhancing anodal and excitability-diminishing cathodal transcranial direct current stimulation (tDCS) and transcranial theta-burst stimulation (TBS), we performed an in vivo assessment of glutamatedependent LTP-like and LTD-like cortical plasticity in schizophrenia patients, their relatives and healthy controls with no family history of schizophrenia. To determine the physiological basis of possible plasticity changes, different inhibitory and facilitatory networks were investigated. Furthermore, the impact of the brain-derived-neurotrophic factor on cortical plasticity was analysed. Results Multi-episode schizophrenia patients showed significantly reduced LTP-like plasticity compared to recent-onset schizophrenia patients and healthy controls. All schizophrenia patients presented abolished LTD-like plasticity and schizophrenia patients showed a dysfunctional plasticity spread (LTD) across hemispheres. First-degree relatives showed an inversed plasticity reaction compared to healthy controls and schizophrenia patients on the non-stimulated hemisphere. Conclusions The pattern of our results provides evidence for a specific plasticity deficit in schizophrenia patients which might be associated with a hyperglutamatergicstate, dysfunctional N -methyl- d -aspartate-receptors and dysfunctional intracortical inhibitory networks across hemispheres. These results indicate that the available transcranial stimulation techniques might be not optimal for the treatment of schizophrenia. New treatment tools need to be developed and the effects of the disease state, medication and the genetic background need to be taken into consideration." @default.
- W2009105760 created "2016-06-24" @default.
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- W2009105760 date "2013-10-01" @default.
- W2009105760 modified "2023-09-23" @default.
- W2009105760 title "IS 32. Impaired cortical plasticity in schizophrenia" @default.
- W2009105760 doi "https://doi.org/10.1016/j.clinph.2013.04.051" @default.
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