Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009109559> ?p ?o ?g. }
- W2009109559 endingPage "3866" @default.
- W2009109559 startingPage "3861" @default.
- W2009109559 abstract "Tolerance to dsDNA is achieved through editing of Ig receptors that react with dsDNA. Nevertheless, some B cells with anti-dsDNA receptors escape editing and migrate to the spleen. Certain anti-dsDNA B cells that are recovered as hybridomas from the spleens of anti-dsDNA H chain transgenic mice also bind an additional, Golgi-associated antigen. B cells that bind this antigen accumulate intracellular IgM. The intracellular accumulation of IgM is incomplete, because IgM clusters are observed at the cell surface. In the spleen, B cells that express the heavy and light chains encoding this IgM are surface IgM-bright and acquire the CD21-high/CD23-low phenotype of marginal zone B cells. Our data imply that expression of an Ig that binds dsDNA and an additional antigen expressed in the secretory compartment renders B cells resistant to central tolerance. In the periphery, these B cells may be sequestered in the splenic marginal zone." @default.
- W2009109559 created "2016-06-24" @default.
- W2009109559 creator A5001279374 @default.
- W2009109559 creator A5001563470 @default.
- W2009109559 creator A5007211696 @default.
- W2009109559 creator A5018230531 @default.
- W2009109559 creator A5023609359 @default.
- W2009109559 creator A5044006568 @default.
- W2009109559 creator A5048644594 @default.
- W2009109559 creator A5060345558 @default.
- W2009109559 creator A5062861953 @default.
- W2009109559 creator A5062932399 @default.
- W2009109559 creator A5067107115 @default.
- W2009109559 date "2008-03-11" @default.
- W2009109559 modified "2023-09-26" @default.
- W2009109559 title "Editing and escape from editing in anti-DNA B cells" @default.
- W2009109559 cites W1491799051 @default.
- W2009109559 cites W1508918383 @default.
- W2009109559 cites W1526921084 @default.
- W2009109559 cites W1582229352 @default.
- W2009109559 cites W1603713705 @default.
- W2009109559 cites W1626010195 @default.
- W2009109559 cites W1978648487 @default.
- W2009109559 cites W1986931210 @default.
- W2009109559 cites W2003956281 @default.
- W2009109559 cites W2007313599 @default.
- W2009109559 cites W2010072801 @default.
- W2009109559 cites W2019650966 @default.
- W2009109559 cites W2033973838 @default.
- W2009109559 cites W2039919570 @default.
- W2009109559 cites W2045594979 @default.
- W2009109559 cites W2047663747 @default.
- W2009109559 cites W2051729351 @default.
- W2009109559 cites W2054828666 @default.
- W2009109559 cites W2076198413 @default.
- W2009109559 cites W2081025743 @default.
- W2009109559 cites W2084935363 @default.
- W2009109559 cites W2092095014 @default.
- W2009109559 cites W2104490952 @default.
- W2009109559 cites W2105705267 @default.
- W2009109559 cites W2106577338 @default.
- W2009109559 cites W2107169792 @default.
- W2009109559 cites W2111300657 @default.
- W2009109559 cites W2113237744 @default.
- W2009109559 cites W2122596811 @default.
- W2009109559 cites W2134544592 @default.
- W2009109559 cites W2134755638 @default.
- W2009109559 cites W2135843106 @default.
- W2009109559 cites W2137787563 @default.
- W2009109559 cites W2137813880 @default.
- W2009109559 cites W2150118150 @default.
- W2009109559 cites W2157499759 @default.
- W2009109559 cites W2158080536 @default.
- W2009109559 cites W2166317148 @default.
- W2009109559 cites W2168536235 @default.
- W2009109559 doi "https://doi.org/10.1073/pnas.0800025105" @default.
- W2009109559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268806" @default.
- W2009109559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18310318" @default.
- W2009109559 hasPublicationYear "2008" @default.
- W2009109559 type Work @default.
- W2009109559 sameAs 2009109559 @default.
- W2009109559 citedByCount "25" @default.
- W2009109559 countsByYear W20091095592012 @default.
- W2009109559 countsByYear W20091095592013 @default.
- W2009109559 countsByYear W20091095592014 @default.
- W2009109559 countsByYear W20091095592015 @default.
- W2009109559 countsByYear W20091095592017 @default.
- W2009109559 countsByYear W20091095592018 @default.
- W2009109559 countsByYear W20091095592019 @default.
- W2009109559 countsByYear W20091095592020 @default.
- W2009109559 countsByYear W20091095592022 @default.
- W2009109559 crossrefType "journal-article" @default.
- W2009109559 hasAuthorship W2009109559A5001279374 @default.
- W2009109559 hasAuthorship W2009109559A5001563470 @default.
- W2009109559 hasAuthorship W2009109559A5007211696 @default.
- W2009109559 hasAuthorship W2009109559A5018230531 @default.
- W2009109559 hasAuthorship W2009109559A5023609359 @default.
- W2009109559 hasAuthorship W2009109559A5044006568 @default.
- W2009109559 hasAuthorship W2009109559A5048644594 @default.
- W2009109559 hasAuthorship W2009109559A5060345558 @default.
- W2009109559 hasAuthorship W2009109559A5062861953 @default.
- W2009109559 hasAuthorship W2009109559A5062932399 @default.
- W2009109559 hasAuthorship W2009109559A5067107115 @default.
- W2009109559 hasBestOaLocation W20091095591 @default.
- W2009109559 hasConcept C111368507 @default.
- W2009109559 hasConcept C119062480 @default.
- W2009109559 hasConcept C127313418 @default.
- W2009109559 hasConcept C141105273 @default.
- W2009109559 hasConcept C147483822 @default.
- W2009109559 hasConcept C153911025 @default.
- W2009109559 hasConcept C158617107 @default.
- W2009109559 hasConcept C159654299 @default.
- W2009109559 hasConcept C170493617 @default.
- W2009109559 hasConcept C203014093 @default.
- W2009109559 hasConcept C203635412 @default.
- W2009109559 hasConcept C2778453870 @default.
- W2009109559 hasConcept C2779921676 @default.
- W2009109559 hasConcept C2780931953 @default.