Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009114557> ?p ?o ?g. }
- W2009114557 endingPage "324" @default.
- W2009114557 startingPage "313" @default.
- W2009114557 abstract "The cytokine transforming growth factor-beta (TGF-beta) has multiple effects on a variety of cell types, modulating cell growth and differentiation as well as extracellular matrix deposition and degradation. In the present work, we demonstrate that TGF-beta1 produces a fourfold increase in transcription of the fibronectin gene in cultured human fetal lung fibroblasts with only a small increase in mRNA stability resulting in a significant increase in fibronectin mRNA steady state level. A corresponding increase in production of fibronectin protein accompanied the increase in mRNA. Through the use of specific inhibitors, we demonstrate that geranylgeranylated, but not farnesylated or acylated protein(s), protein kinase C-delta, phosphatidylcholine-specific phospholipse C, tyrosine kinase activity, and stress-activated protein kinase p38 are required for this TGF-beta1 effect. Trimeric G proteins and mitogen-activated protein kinases erk1 and erk2 do not appear to be involved. While these results emphasize the complexities involved in the control of extracellular matrix synthesis by TGF-beta, they also identify reaction sites that may be amenable to pharmacologic modulation. Such modulation could be of great advantage in the treatment of a wide variety of undesirable fibrotic reactions." @default.
- W2009114557 created "2016-06-24" @default.
- W2009114557 creator A5022736570 @default.
- W2009114557 creator A5035071096 @default.
- W2009114557 creator A5038021583 @default.
- W2009114557 creator A5044268981 @default.
- W2009114557 creator A5046836212 @default.
- W2009114557 creator A5056350826 @default.
- W2009114557 creator A5088529813 @default.
- W2009114557 date "2000-02-01" @default.
- W2009114557 modified "2023-10-12" @default.
- W2009114557 title "TGF-β1 Stimulation of Fibronectin Transcription in Cultured Human Lung Fibroblasts Requires Active Geranylgeranyl Transferase I, Phosphatidylcholine-Specific Phospholipase C, Protein Kinase C-δ, and p38, But Not erk1/erk2" @default.
- W2009114557 cites W1484076261 @default.
- W2009114557 cites W1485105669 @default.
- W2009114557 cites W1493724927 @default.
- W2009114557 cites W1494055834 @default.
- W2009114557 cites W1502031474 @default.
- W2009114557 cites W1505669099 @default.
- W2009114557 cites W1544277307 @default.
- W2009114557 cites W1560334098 @default.
- W2009114557 cites W1593983451 @default.
- W2009114557 cites W1594910624 @default.
- W2009114557 cites W1612683899 @default.
- W2009114557 cites W1641731911 @default.
- W2009114557 cites W1656644300 @default.
- W2009114557 cites W1749711544 @default.
- W2009114557 cites W1755902553 @default.
- W2009114557 cites W1914707020 @default.
- W2009114557 cites W1971413535 @default.
- W2009114557 cites W1971440791 @default.
- W2009114557 cites W1972760976 @default.
- W2009114557 cites W1974836258 @default.
- W2009114557 cites W1983625023 @default.
- W2009114557 cites W1984665850 @default.
- W2009114557 cites W1988942273 @default.
- W2009114557 cites W1990655990 @default.
- W2009114557 cites W1992468405 @default.
- W2009114557 cites W1993535707 @default.
- W2009114557 cites W1996281893 @default.
- W2009114557 cites W2000024512 @default.
- W2009114557 cites W2005792688 @default.
- W2009114557 cites W2013413602 @default.
- W2009114557 cites W2015127183 @default.
- W2009114557 cites W2015595919 @default.
- W2009114557 cites W2018610943 @default.
- W2009114557 cites W2018978380 @default.
- W2009114557 cites W2019303375 @default.
- W2009114557 cites W2028242823 @default.
- W2009114557 cites W2028348480 @default.
- W2009114557 cites W2032621682 @default.
- W2009114557 cites W2035936653 @default.
- W2009114557 cites W2041576624 @default.
- W2009114557 cites W2047186447 @default.
- W2009114557 cites W2060264934 @default.
- W2009114557 cites W2061234826 @default.
- W2009114557 cites W2066945967 @default.
- W2009114557 cites W2070470162 @default.
- W2009114557 cites W2070758335 @default.
- W2009114557 cites W2072710884 @default.
- W2009114557 cites W2075473225 @default.
- W2009114557 cites W2082760271 @default.
- W2009114557 cites W2084877581 @default.
- W2009114557 cites W2086524338 @default.
- W2009114557 cites W2086589373 @default.
- W2009114557 cites W2089257774 @default.
- W2009114557 cites W2089455607 @default.
- W2009114557 cites W2093881154 @default.
- W2009114557 cites W2100398824 @default.
- W2009114557 cites W2106213046 @default.
- W2009114557 cites W2116234410 @default.
- W2009114557 cites W2126638912 @default.
- W2009114557 cites W2129608867 @default.
- W2009114557 cites W2133362776 @default.
- W2009114557 cites W2135757784 @default.
- W2009114557 cites W2136819827 @default.
- W2009114557 cites W2142648830 @default.
- W2009114557 cites W2153724035 @default.
- W2009114557 cites W2157409282 @default.
- W2009114557 cites W2166224134 @default.
- W2009114557 cites W2335187016 @default.
- W2009114557 cites W4294216491 @default.
- W2009114557 doi "https://doi.org/10.1006/abbi.1999.1625" @default.
- W2009114557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10666313" @default.
- W2009114557 hasPublicationYear "2000" @default.
- W2009114557 type Work @default.
- W2009114557 sameAs 2009114557 @default.
- W2009114557 citedByCount "56" @default.
- W2009114557 countsByYear W20091145572012 @default.
- W2009114557 countsByYear W20091145572013 @default.
- W2009114557 countsByYear W20091145572015 @default.
- W2009114557 countsByYear W20091145572016 @default.
- W2009114557 countsByYear W20091145572017 @default.
- W2009114557 countsByYear W20091145572018 @default.
- W2009114557 countsByYear W20091145572019 @default.
- W2009114557 countsByYear W20091145572020 @default.
- W2009114557 countsByYear W20091145572021 @default.
- W2009114557 crossrefType "journal-article" @default.
- W2009114557 hasAuthorship W2009114557A5022736570 @default.