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- W2009115568 abstract "Human subjects are divisible into two clearly defined phenotypes by their capacity to acetylate sulfamethazine. The biochemical basis of this polymorphism lies in the possession of high N-acetyltransferase activity in the liver and intestinal mucosa of rapid acetylators as compared with slow acetylators. No physiological substrate for this polymorphic enzyme system is known. Hexosamines are acetylated in the body and hence could be natural substrates. It has hitherto not proved possible to investigate this problem in vitro by, for example, using human liver homogenates. An indirect approach has therefore been employed and in this study the proportion of hexosamine in human urine which is acetylated has been determined in subjects who have had their acetylator phenotype determined by means of a sulfamethazine test. The results show no significant difference in the acetylation of excreted urinary endogenous hexosamine between the two phenotypes, and thus suggest that the hexosamine found in urine is unlikely to be a natural substrate for the polymorphic N-acetyltransferase." @default.
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- W2009115568 title "Urinary hexosamine and acetyl-hexosamine excretion in human acetylator phenotypes" @default.
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- W2009115568 doi "https://doi.org/10.1016/0009-8981(67)90151-9" @default.
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