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- W2009117004 startingPage "e1001376" @default.
- W2009117004 abstract "The tumor necrosis factor-receptor-associated factor 2 (TRAF2)- and Nck-interacting kinase (TNIK) is a ubiquitously expressed member of the germinal center kinase family. The TNIK functions in hematopoietic cells and the role of TNIK-TRAF interaction remain largely unknown. By functional proteomics we identified TNIK as interaction partner of the latent membrane protein 1 (LMP1) signalosome in primary human B-cells infected with the Epstein-Barr tumor virus (EBV). RNAi-mediated knockdown proved a critical role for TNIK in canonical NF-κB and c-Jun N-terminal kinase (JNK) activation by the major EBV oncoprotein LMP1 and its cellular counterpart, the B-cell co-stimulatory receptor CD40. Accordingly, TNIK is mandatory for proliferation and survival of EBV-transformed B-cells. TNIK forms an activation-induced complex with the critical signaling mediators TRAF6, TAK1/TAB2, and IKKβ, and mediates signalosome formation at LMP1. TNIK directly binds TRAF6, which bridges TNIK's interaction with the C-terminus of LMP1. Separate TNIK domains are involved in NF-κB and JNK signaling, the N-terminal TNIK kinase domain being essential for IKKβ/NF-κB and the C-terminus for JNK activation. We therefore suggest that TNIK orchestrates the bifurcation of both pathways at the level of the TRAF6-TAK1/TAB2-IKK complex. Our data establish TNIK as a novel key player in TRAF6-dependent JNK and NF-κB signaling and a transducer of activating and transforming signals in human B-cells." @default.
- W2009117004 created "2016-06-24" @default.
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- W2009117004 date "2012-08-14" @default.
- W2009117004 modified "2023-09-26" @default.
- W2009117004 title "The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor" @default.
- W2009117004 cites W143287638 @default.
- W2009117004 cites W1491749295 @default.
- W2009117004 cites W1494529291 @default.
- W2009117004 cites W1500780819 @default.
- W2009117004 cites W1505630375 @default.
- W2009117004 cites W1530165617 @default.
- W2009117004 cites W1578954095 @default.
- W2009117004 cites W1594023893 @default.
- W2009117004 cites W1600472471 @default.
- W2009117004 cites W1946559945 @default.
- W2009117004 cites W1964286547 @default.
- W2009117004 cites W1971258489 @default.
- W2009117004 cites W1974768393 @default.
- W2009117004 cites W1977830503 @default.
- W2009117004 cites W1986168751 @default.
- W2009117004 cites W1988587254 @default.
- W2009117004 cites W1989247115 @default.
- W2009117004 cites W1990720057 @default.
- W2009117004 cites W1991902573 @default.
- W2009117004 cites W1995171976 @default.
- W2009117004 cites W1997407816 @default.
- W2009117004 cites W2000432680 @default.
- W2009117004 cites W2001696487 @default.
- W2009117004 cites W2001892258 @default.
- W2009117004 cites W2010339276 @default.
- W2009117004 cites W2014140505 @default.
- W2009117004 cites W2014886648 @default.
- W2009117004 cites W2015183783 @default.
- W2009117004 cites W2018465340 @default.
- W2009117004 cites W2031336507 @default.
- W2009117004 cites W2038295718 @default.
- W2009117004 cites W2039360853 @default.
- W2009117004 cites W2040638887 @default.
- W2009117004 cites W2044526263 @default.
- W2009117004 cites W2048905748 @default.
- W2009117004 cites W2051439103 @default.
- W2009117004 cites W2056257811 @default.
- W2009117004 cites W2057493177 @default.
- W2009117004 cites W2060383679 @default.
- W2009117004 cites W2060652048 @default.
- W2009117004 cites W2065187149 @default.
- W2009117004 cites W2070782085 @default.
- W2009117004 cites W2071506358 @default.
- W2009117004 cites W2077247347 @default.
- W2009117004 cites W2082247484 @default.
- W2009117004 cites W2082351057 @default.
- W2009117004 cites W2087082654 @default.
- W2009117004 cites W2088401014 @default.
- W2009117004 cites W2088846971 @default.
- W2009117004 cites W2090230058 @default.
- W2009117004 cites W2091553731 @default.
- W2009117004 cites W2093791271 @default.
- W2009117004 cites W2101909278 @default.
- W2009117004 cites W2104452138 @default.
- W2009117004 cites W2107956834 @default.
- W2009117004 cites W2110774869 @default.
- W2009117004 cites W2133074755 @default.
- W2009117004 cites W2136656532 @default.
- W2009117004 cites W2138241311 @default.
- W2009117004 cites W2152759163 @default.
- W2009117004 cites W2154142433 @default.
- W2009117004 cites W2156797532 @default.
- W2009117004 cites W2165042359 @default.
- W2009117004 cites W2165768304 @default.
- W2009117004 cites W2167096785 @default.
- W2009117004 cites W2168219542 @default.
- W2009117004 cites W2168531609 @default.
- W2009117004 cites W2418141772 @default.
- W2009117004 cites W291766394 @default.
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- W2009117004 doi "https://doi.org/10.1371/journal.pbio.1001376" @default.
- W2009117004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419181" @default.
- W2009117004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22904686" @default.
- W2009117004 hasPublicationYear "2012" @default.
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