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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009127910> ?p ?o ?g. }

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• W2009127910 abstract "Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself." @default.
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• W2009127910 date "2006-11-10" @default.
• W2009127910 modified "2023-10-05" @default.
• W2009127910 title "RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates" @default.
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• W2009127910 doi "https://doi.org/10.1126/science.1132998" @default.
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