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• W2009130178 abstract "tural conservation of immunogenic proteins such as MOMP. Although the antigenicity of each C. pneumoniae surface protein is not well characterized, a broader range of antibody responses would be detected using these tests. Presumably, to increase specifi city, the authors used WB. Certainly, isolated positive results using MIF or ELISA are diffi cult to interpret because they may represent acute, chronic or previous infection. C. pneumoniae antibody testing in this way is discouraged [5] . However, it is diffi cult to exclude systemic C. pneumoniae infection in patients with MS using antibody testing alone, considering the technical diffi culties with WB. To do this, antigen-specifi c testing of sera is required, either to detect free antigen or immune complexes, a method used in studies of cardiovascular disease [6] . C. pneumoniae is a common cause of respiratory infection in western populations and may become chronic. The majority of serological studies do not support C. pneumoniae as an aetiological agent in MS. However, the rate of systemic infection should be characterised, using antigen-specifi c methods, as chronic bacterial infection in susceptible MS patients may exacerbate the autoimmune pathogenesis. Dear Sir, Dr. Chapman and colleagues [1] demonstrated patients with multiple sclerosis (MS) do not exhibit serum oligoclonal antibody responses to Chlamydophila pneumoniae antigens using Western blotting (WB). The authors concluded that systemic C. pneumoniae infection is not associated with MS. Although one would expect reactive serum oligoclonal bands to C. pneumoniae , should the bacterium be present and pathogenic, WB may not be the most sensitive measurement of C. pneumoniae antibody responses [2] . This may explain the discrepancy between the lower frequency of serum antibody detected by WB in this study compared to the authors’ previous study using the microimmunofl uorescence (MIF) test [3] . Several studies have confi rmed a high prevalence of C. pneumoniae IgG antibodies in both MS patients and controls using MIF [3] . This is expected given the high frequency of antibodies in western populations, in general [4] . Certain surface C. pneumoniae epitopes, particularly the major outer membrane protein (MOMP), are prone to denaturing and cannot be detected using WB [2] . MIF tests and commercially available enzyme-linked immunosorbent assays (ELISA) use whole organisms as the antigenic target with strucReceived: September 16, 2005 Accepted: September 29, 2005 Published online: January 6, 2006" @default.
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• W2009130178 title "Lack of Serum Oligoclonal Antibody Responses to <i>Chlamydophila pneumoniae </i>in Multiple Sclerosis" @default.
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• W2009130178 doi "https://doi.org/10.1159/000090720" @default.
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