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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009132110> ?p ?o ?g. }

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• W2009132110 abstract "Many of aspirin's therapeutic effects arise from its acetylation of cyclooxygenase-2 (COX-2), whereas its antithrombotic and ulcerogenic effects result from its acetylation of COX-1. Here, aspirin-like molecules were designed that preferentially acetylate and irreversibly inactivate COX-2. The most potent of these compounds was o -(acetoxyphenyl)hept-2-ynyl sulfide (APHS). Relative to aspirin, APHS was 60 times as reactive against COX-2 and 100 times as selective for its inhibition; it also inhibited COX-2 in cultured macrophages and colon cancer cells and in the rat air pouch in vivo. Such compounds may lead to the development of aspirin-like drugs for the treatment or prevention of immunological and proliferative diseases without gastrointestinal or hematologic side effects." @default.
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• W2009132110 date "1998-05-22" @default.
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• W2009132110 title "Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2" @default.
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• W2009132110 doi "https://doi.org/10.1126/science.280.5367.1268" @default.
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