FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009132689> ?p ?o ?g. }

• W2009132689 endingPage "491" @default.
• W2009132689 startingPage "486" @default.
• W2009132689 abstract "The authors investigated the impact of the CYP2D6 genotypes on the plasma concentration of paroxetine (PAX) in 55 Japanese psychiatric patients. They were administered 10 to 40 mg/day (24 ± 10.0 mg/day) of PAX and maintained at the same daily dose for at least two weeks to obtain the steady-state concentrations. The plasma levels of PAX were 15.8 ± 15.0, 47.4 ± 32.0, 101.2 ± 59.9 and 177.5 ± 123.6 ng/ml at the daily dose of 10, 20, 30 and 40 mg, respectively, which suggested dose dependent kinetics of PAX. The allele frequencies of the CYP2D6⁎5, CYP2D6⁎10 and CYP2D6⁎41 were 1.8%, 41.8% and 1.8%, respectively. Significantly higher PAX concentrations were observed in the patients having one functional allele compared with those with two functional alleles (150.9 ± 20.6 vs. 243.6 ± 25.2 ng/ml mg− 1 kg− 1, p < 0.05, Newman–Keuls multiple comparison test) or no functional (243.6 ± 25.2 vs. 76.7 ± 6.1 ng/ml mg− 1 kg− 1, p < 0.05, Newman–Keuls multiple comparison test) in the subjects with 30 mg/day of paroxetine. The same trend of findings as in the subjects treated with 30 mg/day were observed in the subjects with 40 mg/day of PAX. The present results suggest that having one non-functional allele is the marker for high plasma concentration of PAX when relatively high daily dose of PAX is administered." @default.
• W2009132689 created "2016-06-24" @default.
• W2009132689 creator A5006217384 @default.
• W2009132689 creator A5007633216 @default.
• W2009132689 creator A5013490553 @default.
• W2009132689 creator A5028999046 @default.
• W2009132689 creator A5039377187 @default.
• W2009132689 creator A5040105473 @default.
• W2009132689 creator A5089238915 @default.
• W2009132689 date "2006-05-01" @default.
• W2009132689 modified "2023-10-07" @default.
• W2009132689 title "The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients" @default.
• W2009132689 cites W1271537196 @default.
• W2009132689 cites W1488321941 @default.
• W2009132689 cites W1960834696 @default.
• W2009132689 cites W1970846917 @default.
• W2009132689 cites W1978945460 @default.
• W2009132689 cites W1981202966 @default.
• W2009132689 cites W1982290436 @default.
• W2009132689 cites W1986761759 @default.
• W2009132689 cites W1988217312 @default.
• W2009132689 cites W1989861091 @default.
• W2009132689 cites W1990611736 @default.
• W2009132689 cites W1992511287 @default.
• W2009132689 cites W1993858402 @default.
• W2009132689 cites W1996644801 @default.
• W2009132689 cites W2007602464 @default.
• W2009132689 cites W2014252886 @default.
• W2009132689 cites W2014756391 @default.
• W2009132689 cites W2037855670 @default.
• W2009132689 cites W2048984349 @default.
• W2009132689 cites W2051143890 @default.
• W2009132689 cites W2064096935 @default.
• W2009132689 cites W2069157036 @default.
• W2009132689 cites W2072116990 @default.
• W2009132689 cites W2074792668 @default.
• W2009132689 cites W2083229713 @default.
• W2009132689 cites W2095023269 @default.
• W2009132689 cites W2103946220 @default.
• W2009132689 cites W2107472157 @default.
• W2009132689 cites W2111731642 @default.
• W2009132689 cites W2170078964 @default.
• W2009132689 cites W2184940291 @default.
• W2009132689 cites W2335687005 @default.
• W2009132689 cites W81383981 @default.
• W2009132689 doi "https://doi.org/10.1016/j.pnpbp.2005.11.007" @default.
• W2009132689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16423440" @default.
• W2009132689 hasPublicationYear "2006" @default.
• W2009132689 type Work @default.
• W2009132689 sameAs 2009132689 @default.
• W2009132689 citedByCount "33" @default.
• W2009132689 countsByYear W20091326892013 @default.
• W2009132689 countsByYear W20091326892014 @default.
• W2009132689 countsByYear W20091326892015 @default.
• W2009132689 countsByYear W20091326892016 @default.
• W2009132689 countsByYear W20091326892018 @default.
• W2009132689 countsByYear W20091326892019 @default.
• W2009132689 countsByYear W20091326892021 @default.
• W2009132689 crossrefType "journal-article" @default.
• W2009132689 hasAuthorship W2009132689A5006217384 @default.
• W2009132689 hasAuthorship W2009132689A5007633216 @default.
• W2009132689 hasAuthorship W2009132689A5013490553 @default.
• W2009132689 hasAuthorship W2009132689A5028999046 @default.
• W2009132689 hasAuthorship W2009132689A5039377187 @default.
• W2009132689 hasAuthorship W2009132689A5040105473 @default.
• W2009132689 hasAuthorship W2009132689A5089238915 @default.
• W2009132689 hasConcept C104317684 @default.
• W2009132689 hasConcept C126322002 @default.
• W2009132689 hasConcept C134018914 @default.
• W2009132689 hasConcept C135763542 @default.
• W2009132689 hasConcept C170493617 @default.
• W2009132689 hasConcept C180754005 @default.
• W2009132689 hasConcept C185592680 @default.
• W2009132689 hasConcept C2775864247 @default.
• W2009132689 hasConcept C2777828372 @default.
• W2009132689 hasConcept C3017575891 @default.
• W2009132689 hasConcept C3020079912 @default.
• W2009132689 hasConcept C33664856 @default.
• W2009132689 hasConcept C526171541 @default.
• W2009132689 hasConcept C55493867 @default.
• W2009132689 hasConcept C62231903 @default.
• W2009132689 hasConcept C71924100 @default.
• W2009132689 hasConcept C98274493 @default.
• W2009132689 hasConceptScore W2009132689C104317684 @default.
• W2009132689 hasConceptScore W2009132689C126322002 @default.
• W2009132689 hasConceptScore W2009132689C134018914 @default.
• W2009132689 hasConceptScore W2009132689C135763542 @default.
• W2009132689 hasConceptScore W2009132689C170493617 @default.
• W2009132689 hasConceptScore W2009132689C180754005 @default.
• W2009132689 hasConceptScore W2009132689C185592680 @default.
• W2009132689 hasConceptScore W2009132689C2775864247 @default.
• W2009132689 hasConceptScore W2009132689C2777828372 @default.
• W2009132689 hasConceptScore W2009132689C3017575891 @default.
• W2009132689 hasConceptScore W2009132689C3020079912 @default.
• W2009132689 hasConceptScore W2009132689C33664856 @default.
• W2009132689 hasConceptScore W2009132689C526171541 @default.
• W2009132689 hasConceptScore W2009132689C55493867 @default.
• W2009132689 hasConceptScore W2009132689C62231903 @default.

• next