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- W2009137239 abstract "Cyanamide (H2N—C N) is effective as an agent to treat alcoholism presumably because it inhibits aldehyde dehydrogenase. In this study it was found that, in vivo, cyanamide is a very potent inhibitor of liver aldehyde dehydrogenases. but less effective against the brain enzymes. The ED50 for liver was found to be 8 mg/kg when given intraperitoneally. The inhibition diminishes with time but is measurable for at least 24 hr, even though the bulk of the 14C-labeled cyanamide is excreted within 6 hr. Cyanamide is not effective when added to the assay mixture in vitro, suggesting that a metabolite is the inhibitor in vivo. A urinary metabolite has been isolated and partially characterized. It is an acid with a pKa' of 3.9 and an extinction coefficient of 1.72 × 103 in base at 219 nm; the compound apparently retains the cyano group. However, it does not inhibit the enzyme in vitro." @default.
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- W2009137239 title "Inhibition of aldehyde dehydrogenase in brain and liver by cyanamide" @default.
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- W2009137239 doi "https://doi.org/10.1016/0006-2952(76)90265-3" @default.
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