FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009144057> ?p ?o ?g. }

• W2009144057 endingPage "373" @default.
• W2009144057 startingPage "369" @default.
• W2009144057 abstract "DNA vaccines are attracting increased attention due to multiple advantages over conventional vaccines. Attempts to improve these vaccines focus on enhancing DNA delivery and employing novel immunoadjuvants. Electroporation (EP) has emerged as an effective method for delivering DNA vaccines, significantly enhancing humoral and cellular responses. To further improve EP-augmented DNA vaccination, we used micron-size gold particles as a particulate adjuvant. DNA is not bound, or adsorbed, to the particles. Gold particles were coinjected intradermally with plasmid DNA encoding the hepatitis B virus surface antigen (HBsAg) into mice, both in the absence and presence of noninvasive EP. The particles enhanced the percentage of responding animals, and shortened the time for reaching maximal antibody titers by 2 weeks. Subtyping of the produced antibodies revealed a predominantly Th1-like response which did not change significantly with the absence or presence of particles. The particles likely function as an attractant for antigen-presenting cells (APCs), and probably do not affect EP or antigen expression to a significant extent. We conclude that micron-size gold particles injected intradermally together with DNA followed by EP give rise to an accelerated, potent immune response with a strong cellular component. This method may become important for the development of fast-acting therapeutic and prophylactic vaccines." @default.
• W2009144057 created "2016-06-24" @default.
• W2009144057 creator A5045345765 @default.
• W2009144057 creator A5071798264 @default.
• W2009144057 creator A5081021416 @default.
• W2009144057 date "2004-06-01" @default.
• W2009144057 modified "2023-09-23" @default.
• W2009144057 title "Enhancement of the effectiveness of electroporation-augmented cutaneous DNA vaccination by a particulate adjuvant" @default.
• W2009144057 cites W1565953572 @default.
• W2009144057 cites W1594950156 @default.
• W2009144057 cites W1965810830 @default.
• W2009144057 cites W1991809645 @default.
• W2009144057 cites W2014495927 @default.
• W2009144057 cites W2016303771 @default.
• W2009144057 cites W2032572780 @default.
• W2009144057 cites W2034166814 @default.
• W2009144057 cites W2056877436 @default.
• W2009144057 cites W2058395594 @default.
• W2009144057 cites W2061142961 @default.
• W2009144057 cites W2076755225 @default.
• W2009144057 cites W2097738098 @default.
• W2009144057 cites W2124850461 @default.
• W2009144057 cites W4253743949 @default.
• W2009144057 cites W4254226967 @default.
• W2009144057 doi "https://doi.org/10.1016/j.bioelechem.2003.11.011" @default.
• W2009144057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15110305" @default.
• W2009144057 hasPublicationYear "2004" @default.
• W2009144057 type Work @default.
• W2009144057 sameAs 2009144057 @default.
• W2009144057 citedByCount "45" @default.
• W2009144057 countsByYear W20091440572012 @default.
• W2009144057 countsByYear W20091440572013 @default.
• W2009144057 countsByYear W20091440572015 @default.
• W2009144057 countsByYear W20091440572017 @default.
• W2009144057 countsByYear W20091440572019 @default.
• W2009144057 countsByYear W20091440572021 @default.
• W2009144057 countsByYear W20091440572022 @default.
• W2009144057 countsByYear W20091440572023 @default.
• W2009144057 crossrefType "journal-article" @default.
• W2009144057 hasAuthorship W2009144057A5045345765 @default.
• W2009144057 hasAuthorship W2009144057A5071798264 @default.
• W2009144057 hasAuthorship W2009144057A5081021416 @default.
• W2009144057 hasConcept C104317684 @default.
• W2009144057 hasConcept C147483822 @default.
• W2009144057 hasConcept C159047783 @default.
• W2009144057 hasConcept C159654299 @default.
• W2009144057 hasConcept C167508917 @default.
• W2009144057 hasConcept C185592680 @default.
• W2009144057 hasConcept C186852380 @default.
• W2009144057 hasConcept C203014093 @default.
• W2009144057 hasConcept C22070199 @default.
• W2009144057 hasConcept C2522874641 @default.
• W2009144057 hasConcept C2777410769 @default.
• W2009144057 hasConcept C2777863537 @default.
• W2009144057 hasConcept C2780593183 @default.
• W2009144057 hasConcept C2780801004 @default.
• W2009144057 hasConcept C32611913 @default.
• W2009144057 hasConcept C552990157 @default.
• W2009144057 hasConcept C55493867 @default.
• W2009144057 hasConcept C86803240 @default.
• W2009144057 hasConcept C8891405 @default.
• W2009144057 hasConceptScore W2009144057C104317684 @default.
• W2009144057 hasConceptScore W2009144057C147483822 @default.
• W2009144057 hasConceptScore W2009144057C159047783 @default.
• W2009144057 hasConceptScore W2009144057C159654299 @default.
• W2009144057 hasConceptScore W2009144057C167508917 @default.
• W2009144057 hasConceptScore W2009144057C185592680 @default.
• W2009144057 hasConceptScore W2009144057C186852380 @default.
• W2009144057 hasConceptScore W2009144057C203014093 @default.
• W2009144057 hasConceptScore W2009144057C22070199 @default.
• W2009144057 hasConceptScore W2009144057C2522874641 @default.
• W2009144057 hasConceptScore W2009144057C2777410769 @default.
• W2009144057 hasConceptScore W2009144057C2777863537 @default.
• W2009144057 hasConceptScore W2009144057C2780593183 @default.
• W2009144057 hasConceptScore W2009144057C2780801004 @default.
• W2009144057 hasConceptScore W2009144057C32611913 @default.
• W2009144057 hasConceptScore W2009144057C552990157 @default.
• W2009144057 hasConceptScore W2009144057C55493867 @default.
• W2009144057 hasConceptScore W2009144057C86803240 @default.
• W2009144057 hasConceptScore W2009144057C8891405 @default.
• W2009144057 hasIssue "1-2" @default.
• W2009144057 hasLocation W20091440571 @default.
• W2009144057 hasLocation W20091440572 @default.
• W2009144057 hasOpenAccess W2009144057 @default.
• W2009144057 hasPrimaryLocation W20091440571 @default.
• W2009144057 hasRelatedWork W1539989077 @default.
• W2009144057 hasRelatedWork W1928648264 @default.
• W2009144057 hasRelatedWork W2048230388 @default.
• W2009144057 hasRelatedWork W2072712054 @default.
• W2009144057 hasRelatedWork W2084270562 @default.
• W2009144057 hasRelatedWork W2143941734 @default.
• W2009144057 hasRelatedWork W2279361636 @default.
• W2009144057 hasRelatedWork W2359884338 @default.
• W2009144057 hasRelatedWork W2382746499 @default.
• W2009144057 hasRelatedWork W1840551154 @default.
• W2009144057 hasVolume "63" @default.
• W2009144057 isParatext "false" @default.
• W2009144057 isRetracted "false" @default.

• next