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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009145259> ?p ?o ?g. }

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• W2009145259 abstract "Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mouse brain tumor model induced by retroviral Ras expression on a p16 Ink4a /p19 Arf -deficient background. The NS-GFP system allowed us to monitor the differentiation process of normal neural stem/precursor cells by analyzing GFP fluorescence intensity. In tumor-bearing mice, despite the very high frequency of tumorigenic cells, we successfully identified the NS-GFP + cells as tumor-initiating cells (T-ICs). The clonal studies conclusively established that phenotypical heterogeneity can exist among the cells comprising a genetically homogeneous tumor, suggesting that this aggressive brain tumor follows the CSC model. Detailed analyses of the NS-GFP + brain tumor cells revealed that T-ICs showed activation of the receptor tyrosine kinase c-Met, which functions in tumor invasiveness. Thus, the NS-GFP system provides a powerful tool to elucidate stem cell biology in normal and malignant tissues." @default.
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• W2009145259 date "2009-10-06" @default.
• W2009145259 modified "2023-09-27" @default.
• W2009145259 title "Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin" @default.
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• W2009145259 doi "https://doi.org/10.1073/pnas.0905016106" @default.
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