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- W2009154254 abstract "Sickle cell disease (SCD) is a recessive genetic blood disorder that is hallmarked by pain. There are currently no validated assessment tools to evaluate the impact of pain on adults with SCD. We sought to further evaluate the Sickle Cell Pain Burden Interview (SCPBI), a brief 7-item functional assessment tool, in an older group of individuals with SCD. The SCPBI was previously validated in 129 youth with SCD. The SCPBI measures pain impact over the previous 4 weeks. Scores on the SCPBI range from 0 to 28—with higher scores indicating a higher pain burden. The Consortium for the Advancement of Sickle Cell Research (CASIRE) is an international collaborative research group with sites in the United States, Europe, and Africa. Using data from the CASIRE Renal Cohort 83 participants with SCD at 4 sites in the US completed a self-reported brief medical history and SCPBI. Data was collected once in a clinic setting, when patients were at least 2 weeks from a vasoocclusive event. Mean age was 21.3 years (σ=11.4), 75% had HgSS, 60% were female, 92% reported their race as being Black, and mean pain burden was 6.3 (σ=6.1). Pain burden correlated significantly with frequency of pain crises per month (r=0.39, p=0.002), pain crises per year (r=0.44, p<0.001), pain crises managed at home (r=0.45, p<0.001), pain crises managed at the emergency department (r=0.44, p<0.001), and pain crises requiring hospital admission (r=0.41, p<0.001). Mean pain burden was higher for patients who reported having gallstones (8.0 vs. 4.9; t=2.2, p=0.03), a previous cholecystectomy (8.9 vs. 4.5; t=3.2, p=0.002), and avascular necrosis (10.5 vs. 5.6; t=2.5, p=0.015). The SCPBI provides a rapid method to assess pain impact in individuals with SCD and correlates well with other indicators of pain in this population." @default.
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- W2009154254 date "2014-04-01" @default.
- W2009154254 modified "2023-09-27" @default.
- W2009154254 title "(231) Assessment of pain impact in sickle cell disease using the sickle cell pain burden interview: association with other clinical factors" @default.
- W2009154254 doi "https://doi.org/10.1016/j.jpain.2014.01.138" @default.
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