FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009161521> ?p ?o ?g. }

• W2009161521 endingPage "491" @default.
• W2009161521 startingPage "485" @default.
• W2009161521 abstract "The combined treatment with interferon beta (IFNbeta) and glatiramer acetate (GA) is of current interest in multiple sclerosis (MS). The therapeutic effect of GA in MS is believed to be mediated by GA-specific Th2 cells. IFNbeta has a significant anti-proliferative effect on GA-induced lymphoproliferation in vitro. Therefore, we examined the possibility that IFNbeta may interfere with the generation and phenotype of GA T-cell responses in MS patients receiving combined therapy. Sixty-six GA-specific T-cell lines (TCL) were generated ex vivo from five MS patients enrolled in an open-label dinical trial of combined IFNbeta/GA treatment. Controls included 83 pretreatment and 131 on-treatment GA-TCL from 11 MS patients treated with GA only, and five GA-TCL generated from four patients receiving IFNbeta-1a monotherapy. IFNgamma and IL-5 (markers of Th1 and Th2 responses, respectively) were assayed by ELISA in GA-TCL supematants. Th1/Th2 bias was defined by the IFNgamma/IL-5 level ratio ( >2 = Th1 bias, <0.5 = Th2 bias, and 0.5-2 = Th0 bias). The frequency with which GA-reactive TCL were generated was 37.0% for the patients in the combination trial compared to 33.3% in the patients receiving GA alone. The mean stimulation index of the GA-TCL was 8.41 (range 2-42) for the combination compared to a mean of 6.29 (range 2-37) for the GA-treated group--a nonsignificant difference. Mean GA-TCL IFNgamma production was significantly lower in all treatment groups compared to pretreatment IL-5 levels were enhanced in all treatment groups compared to pretreatment levels, but the change was not statistically significant. The Th1/Th0/Th2 distribution of GA-TCL was 7%/30%/63% for the GA+IFNbeta group, 8%/9%/83% for the GA group, compared to 48%/21%/31% pre-GA treatment. All five GA-TCL from the IFNbeta-1a monotherapy patients were Th2-biased. We conclude that IFNbeta-1a does not affect the generation of GA-reactive T cells in vivo. Although more Th0 G4-TCL occurred with combination therapy than with G4 treatment alone, both groups shared an overall Th2 bias. Therefore, we speculate that combined therapy is unlikely to reduce the efficacy of GA treatment in MS." @default.
• W2009161521 created "2016-06-24" @default.
• W2009161521 creator A5042378537 @default.
• W2009161521 creator A5056419667 @default.
• W2009161521 creator A5056460527 @default.
• W2009161521 creator A5069539872 @default.
• W2009161521 creator A5076747036 @default.
• W2009161521 creator A5091278896 @default.
• W2009161521 date "2002-12-01" @default.
• W2009161521 modified "2023-09-24" @default.
• W2009161521 title "Effect of combined IFNb-1a and glatiramer acetate therapy on GA-specific T-cell responses in multiple sclerosis" @default.
• W2009161521 cites W1988926940 @default.
• W2009161521 cites W1989217326 @default.
• W2009161521 cites W2013680985 @default.
• W2009161521 cites W2015916378 @default.
• W2009161521 cites W2017605183 @default.
• W2009161521 cites W2018080001 @default.
• W2009161521 cites W2020047554 @default.
• W2009161521 cites W2021435584 @default.
• W2009161521 cites W2029828395 @default.
• W2009161521 cites W2035445993 @default.
• W2009161521 cites W2043704221 @default.
• W2009161521 cites W2066124230 @default.
• W2009161521 cites W2069947868 @default.
• W2009161521 cites W2081804994 @default.
• W2009161521 cites W2103255085 @default.
• W2009161521 cites W2127671643 @default.
• W2009161521 cites W2128340726 @default.
• W2009161521 cites W2157600853 @default.
• W2009161521 cites W2163113037 @default.
• W2009161521 cites W2171907184 @default.
• W2009161521 cites W2315090522 @default.
• W2009161521 cites W2319749898 @default.
• W2009161521 doi "https://doi.org/10.1191/1352458502ms862oa" @default.
• W2009161521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12474988" @default.
• W2009161521 hasPublicationYear "2002" @default.
• W2009161521 type Work @default.
• W2009161521 sameAs 2009161521 @default.
• W2009161521 citedByCount "18" @default.
• W2009161521 countsByYear W20091615212012 @default.
• W2009161521 countsByYear W20091615212013 @default.
• W2009161521 countsByYear W20091615212015 @default.
• W2009161521 countsByYear W20091615212020 @default.
• W2009161521 crossrefType "journal-article" @default.
• W2009161521 hasAuthorship W2009161521A5042378537 @default.
• W2009161521 hasAuthorship W2009161521A5056419667 @default.
• W2009161521 hasAuthorship W2009161521A5056460527 @default.
• W2009161521 hasAuthorship W2009161521A5069539872 @default.
• W2009161521 hasAuthorship W2009161521A5076747036 @default.
• W2009161521 hasAuthorship W2009161521A5091278896 @default.
• W2009161521 hasConcept C126322002 @default.
• W2009161521 hasConcept C168563851 @default.
• W2009161521 hasConcept C203014093 @default.
• W2009161521 hasConcept C2778577042 @default.
• W2009161521 hasConcept C2780640218 @default.
• W2009161521 hasConcept C2908698914 @default.
• W2009161521 hasConcept C2994247566 @default.
• W2009161521 hasConcept C71924100 @default.
• W2009161521 hasConcept C90924648 @default.
• W2009161521 hasConcept C98274493 @default.
• W2009161521 hasConceptScore W2009161521C126322002 @default.
• W2009161521 hasConceptScore W2009161521C168563851 @default.
• W2009161521 hasConceptScore W2009161521C203014093 @default.
• W2009161521 hasConceptScore W2009161521C2778577042 @default.
• W2009161521 hasConceptScore W2009161521C2780640218 @default.
• W2009161521 hasConceptScore W2009161521C2908698914 @default.
• W2009161521 hasConceptScore W2009161521C2994247566 @default.
• W2009161521 hasConceptScore W2009161521C71924100 @default.
• W2009161521 hasConceptScore W2009161521C90924648 @default.
• W2009161521 hasConceptScore W2009161521C98274493 @default.
• W2009161521 hasIssue "6" @default.
• W2009161521 hasLocation W20091615211 @default.
• W2009161521 hasLocation W20091615212 @default.
• W2009161521 hasOpenAccess W2009161521 @default.
• W2009161521 hasPrimaryLocation W20091615211 @default.
• W2009161521 hasRelatedWork W1979678808 @default.
• W2009161521 hasRelatedWork W1983662281 @default.
• W2009161521 hasRelatedWork W2000443242 @default.
• W2009161521 hasRelatedWork W2083083635 @default.
• W2009161521 hasRelatedWork W2099167011 @default.
• W2009161521 hasRelatedWork W2099862278 @default.
• W2009161521 hasRelatedWork W2144095014 @default.
• W2009161521 hasRelatedWork W3155971544 @default.
• W2009161521 hasRelatedWork W2181985636 @default.
• W2009161521 hasRelatedWork W2909629253 @default.
• W2009161521 hasVolume "8" @default.
• W2009161521 isParatext "false" @default.
• W2009161521 isRetracted "false" @default.
• W2009161521 magId "2009161521" @default.
• W2009161521 workType "article" @default.