FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009161818> ?p ?o ?g. }

• W2009161818 endingPage "282" @default.
• W2009161818 startingPage "278" @default.
• W2009161818 abstract "Various high-performance liquid chromatographic (HPLC) methods for the determination of plasma levels of l-dopa and of its metabolite, 3-O-methyldopa (3-OMD), have been previously described. In this study, we report a modification of these methods, that enables the assay of these two compounds in platelets and plasma obtained from the same sample of whole blood. Reversed-phase (RP) HPLC with electrochemical (coulometric) detection was used. The within-run and between-run coefficients of variations, for the two compounds, were less than 10%, in both platelets and plasma; the detection limits for platelet levels of l-dopa and 3-OMD were 2 and 6 ng/109 platelets, respectively. In plasma, the detection limits for l-dopa and 3-OMD were 1 and 3 ng/ml, respectively. The method is rapid and simple. When applied to a population of patients with Parkinson's disease under treatment with l-dopa, this method revealed detectable levels of l-dopa and 3-OMD in the platelets of all patients. The application of this technique may provide new insights into the pharmacokinetics of l-dopa in patients with Parkinson's disease." @default.
• W2009161818 created "2016-06-24" @default.
• W2009161818 creator A5007019878 @default.
• W2009161818 creator A5033117643 @default.
• W2009161818 creator A5034094180 @default.
• W2009161818 creator A5071903262 @default.
• W2009161818 creator A5073526019 @default.
• W2009161818 creator A5074464956 @default.
• W2009161818 date "1997-10-01" @default.
• W2009161818 modified "2023-10-16" @default.
• W2009161818 title "Simultaneous determination of l-dopa and 3-O-methyldopa in human platelets and plasma using high-performance liquid chromatography with electrochemical detection" @default.
• W2009161818 cites W1964616197 @default.
• W2009161818 cites W1970797730 @default.
• W2009161818 cites W1983862619 @default.
• W2009161818 cites W1999545887 @default.
• W2009161818 cites W2000353278 @default.
• W2009161818 cites W2007189280 @default.
• W2009161818 cites W2015541775 @default.
• W2009161818 cites W2028570048 @default.
• W2009161818 cites W2034816810 @default.
• W2009161818 cites W2048913643 @default.
• W2009161818 cites W2056233773 @default.
• W2009161818 cites W2080628968 @default.
• W2009161818 cites W2084539833 @default.
• W2009161818 cites W2085358382 @default.
• W2009161818 cites W2089976483 @default.
• W2009161818 cites W2109350696 @default.
• W2009161818 cites W2142617340 @default.
• W2009161818 cites W2411387684 @default.
• W2009161818 cites W4255433669 @default.
• W2009161818 doi "https://doi.org/10.1016/s0378-4347(97)00307-1" @default.
• W2009161818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9390741" @default.
• W2009161818 hasPublicationYear "1997" @default.
• W2009161818 type Work @default.
• W2009161818 sameAs 2009161818 @default.
• W2009161818 citedByCount "40" @default.
• W2009161818 countsByYear W20091618182012 @default.
• W2009161818 countsByYear W20091618182014 @default.
• W2009161818 countsByYear W20091618182015 @default.
• W2009161818 countsByYear W20091618182019 @default.
• W2009161818 countsByYear W20091618182020 @default.
• W2009161818 countsByYear W20091618182022 @default.
• W2009161818 countsByYear W20091618182023 @default.
• W2009161818 crossrefType "journal-article" @default.
• W2009161818 hasAuthorship W2009161818A5007019878 @default.
• W2009161818 hasAuthorship W2009161818A5033117643 @default.
• W2009161818 hasAuthorship W2009161818A5034094180 @default.
• W2009161818 hasAuthorship W2009161818A5071903262 @default.
• W2009161818 hasAuthorship W2009161818A5073526019 @default.
• W2009161818 hasAuthorship W2009161818A5074464956 @default.
• W2009161818 hasConcept C109379892 @default.
• W2009161818 hasConcept C112705442 @default.
• W2009161818 hasConcept C119128265 @default.
• W2009161818 hasConcept C126322002 @default.
• W2009161818 hasConcept C147789679 @default.
• W2009161818 hasConcept C17525397 @default.
• W2009161818 hasConcept C179998833 @default.
• W2009161818 hasConcept C185592680 @default.
• W2009161818 hasConcept C2777477808 @default.
• W2009161818 hasConcept C43617362 @default.
• W2009161818 hasConcept C52859227 @default.
• W2009161818 hasConcept C55493867 @default.
• W2009161818 hasConcept C71924100 @default.
• W2009161818 hasConcept C89560881 @default.
• W2009161818 hasConcept C98274493 @default.
• W2009161818 hasConceptScore W2009161818C109379892 @default.
• W2009161818 hasConceptScore W2009161818C112705442 @default.
• W2009161818 hasConceptScore W2009161818C119128265 @default.
• W2009161818 hasConceptScore W2009161818C126322002 @default.
• W2009161818 hasConceptScore W2009161818C147789679 @default.
• W2009161818 hasConceptScore W2009161818C17525397 @default.
• W2009161818 hasConceptScore W2009161818C179998833 @default.
• W2009161818 hasConceptScore W2009161818C185592680 @default.
• W2009161818 hasConceptScore W2009161818C2777477808 @default.
• W2009161818 hasConceptScore W2009161818C43617362 @default.
• W2009161818 hasConceptScore W2009161818C52859227 @default.
• W2009161818 hasConceptScore W2009161818C55493867 @default.
• W2009161818 hasConceptScore W2009161818C71924100 @default.
• W2009161818 hasConceptScore W2009161818C89560881 @default.
• W2009161818 hasConceptScore W2009161818C98274493 @default.
• W2009161818 hasIssue "1-2" @default.
• W2009161818 hasLocation W20091618181 @default.
• W2009161818 hasLocation W20091618182 @default.
• W2009161818 hasOpenAccess W2009161818 @default.
• W2009161818 hasPrimaryLocation W20091618181 @default.
• W2009161818 hasRelatedWork W1753739957 @default.
• W2009161818 hasRelatedWork W2009188084 @default.
• W2009161818 hasRelatedWork W2056717580 @default.
• W2009161818 hasRelatedWork W2062837113 @default.
• W2009161818 hasRelatedWork W2076372528 @default.
• W2009161818 hasRelatedWork W2356535066 @default.
• W2009161818 hasRelatedWork W2597805897 @default.
• W2009161818 hasRelatedWork W3094992274 @default.
• W2009161818 hasRelatedWork W74375557 @default.
• W2009161818 hasRelatedWork W2521903434 @default.
• W2009161818 hasVolume "700" @default.
• W2009161818 isParatext "false" @default.
• W2009161818 isRetracted "false" @default.

• next