FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009164582> ?p ?o ?g. }

• W2009164582 endingPage "4897" @default.
• W2009164582 startingPage "4885" @default.
• W2009164582 abstract "Abstract Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a cohort of human breast tumors grown in the epithelium-free mammary fat pad of severe combined immunodeficient (SCID)/Beige and nonobese diabetic (NOD)/SCID/IL-2γ-receptor null (NSG) mice under a series of transplant conditions. Both models yielded stably transplantable xenografts at comparably high rates (∼21% and ∼19%, respectively). Of the conditions tested, xenograft take rate was highest in the presence of a low-dose estradiol pellet. Overall, 32 stably transplantable xenograft lines were established, representing 25 unique patients. Most tumors yielding xenografts were “triple-negative” [estrogen receptor (ER)−progesterone receptor (PR)−HER2+; n = 19]. However, we established lines from 3 ER−PR−HER2+ tumors, one ER+PR−HER2−, one ER+PR+HER2−, and one “triple-positive” (ER+PR+HER2+) tumor. Serially passaged xenografts show biologic consistency with the tumor of origin, are phenotypically stable across multiple transplant generations at the histologic, transcriptomic, proteomic, and genomic levels, and show comparable treatment responses as those observed clinically. Xenografts representing 12 patients, including 2 ER+ lines, showed metastasis to the mouse lung. These models thus serve as a renewable, quality-controlled tissue resource for preclinical studies investigating treatment response and metastasis. Cancer Res; 73(15); 4885–97. ©2013 AACR." @default.
• W2009164582 created "2016-06-24" @default.
• W2009164582 creator A5005221518 @default.
• W2009164582 creator A5013695720 @default.
• W2009164582 creator A5013969500 @default.
• W2009164582 creator A5021488024 @default.
• W2009164582 creator A5022098811 @default.
• W2009164582 creator A5023898240 @default.
• W2009164582 creator A5027371618 @default.
• W2009164582 creator A5030115311 @default.
• W2009164582 creator A5032032019 @default.
• W2009164582 creator A5034056143 @default.
• W2009164582 creator A5037254064 @default.
• W2009164582 creator A5038280418 @default.
• W2009164582 creator A5039126001 @default.
• W2009164582 creator A5040020339 @default.
• W2009164582 creator A5044175725 @default.
• W2009164582 creator A5058451751 @default.
• W2009164582 creator A5061264992 @default.
• W2009164582 creator A5068730234 @default.
• W2009164582 creator A5072387201 @default.
• W2009164582 creator A5072850149 @default.
• W2009164582 creator A5073398031 @default.
• W2009164582 creator A5080705891 @default.
• W2009164582 creator A5080914070 @default.
• W2009164582 creator A5081898233 @default.
• W2009164582 creator A5082726917 @default.
• W2009164582 creator A5083216042 @default.
• W2009164582 creator A5087766403 @default.
• W2009164582 creator A5089513581 @default.
• W2009164582 creator A5091466661 @default.
• W2009164582 date "2013-07-31" @default.
• W2009164582 modified "2023-10-16" @default.
• W2009164582 title "A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models" @default.
• W2009164582 cites W1546709038 @default.
• W2009164582 cites W1838759522 @default.
• W2009164582 cites W1969351768 @default.
• W2009164582 cites W1981421409 @default.
• W2009164582 cites W1990161332 @default.
• W2009164582 cites W1997381761 @default.
• W2009164582 cites W2005706175 @default.
• W2009164582 cites W2010905001 @default.
• W2009164582 cites W2021661053 @default.
• W2009164582 cites W2022248239 @default.
• W2009164582 cites W2023427658 @default.
• W2009164582 cites W2029281176 @default.
• W2009164582 cites W2034428193 @default.
• W2009164582 cites W2034674612 @default.
• W2009164582 cites W2043416876 @default.
• W2009164582 cites W2046584993 @default.
• W2009164582 cites W2051017987 @default.
• W2009164582 cites W2054122205 @default.
• W2009164582 cites W2088954638 @default.
• W2009164582 cites W2098032421 @default.
• W2009164582 cites W2098740402 @default.
• W2009164582 cites W2103663550 @default.
• W2009164582 cites W2103875073 @default.
• W2009164582 cites W2106292881 @default.
• W2009164582 cites W2122667310 @default.
• W2009164582 cites W2126983941 @default.
• W2009164582 cites W2127133796 @default.
• W2009164582 cites W2129843621 @default.
• W2009164582 cites W2130870648 @default.
• W2009164582 cites W2132619562 @default.
• W2009164582 cites W2135696440 @default.
• W2009164582 cites W2138911924 @default.
• W2009164582 cites W2140987848 @default.
• W2009164582 cites W2141815918 @default.
• W2009164582 cites W2142112207 @default.
• W2009164582 cites W2146308386 @default.
• W2009164582 cites W2155173012 @default.
• W2009164582 cites W2156486984 @default.
• W2009164582 cites W2162647235 @default.
• W2009164582 cites W2166311434 @default.
• W2009164582 cites W2171015053 @default.
• W2009164582 cites W2255590571 @default.
• W2009164582 cites W96290679 @default.
• W2009164582 doi "https://doi.org/10.1158/0008-5472.can-12-4081" @default.
• W2009164582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732575" @default.
• W2009164582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23737486" @default.
• W2009164582 hasPublicationYear "2013" @default.
• W2009164582 type Work @default.
• W2009164582 sameAs 2009164582 @default.
• W2009164582 citedByCount "384" @default.
• W2009164582 countsByYear W20091645822013 @default.
• W2009164582 countsByYear W20091645822014 @default.
• W2009164582 countsByYear W20091645822015 @default.
• W2009164582 countsByYear W20091645822016 @default.
• W2009164582 countsByYear W20091645822017 @default.
• W2009164582 countsByYear W20091645822018 @default.
• W2009164582 countsByYear W20091645822019 @default.
• W2009164582 countsByYear W20091645822020 @default.
• W2009164582 countsByYear W20091645822021 @default.
• W2009164582 countsByYear W20091645822022 @default.
• W2009164582 countsByYear W20091645822023 @default.
• W2009164582 crossrefType "journal-article" @default.
• W2009164582 hasAuthorship W2009164582A5005221518 @default.
• W2009164582 hasAuthorship W2009164582A5013695720 @default.

• next