FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009165045> ?p ?o ?g. }

• W2009165045 endingPage "5820" @default.
• W2009165045 startingPage "5815" @default.
• W2009165045 abstract "Many biomaterials are designed to regulate the interactions between artificial and natural surfaces. However, when materials are inserted through the cell membrane itself the interface formed between the interior edge of the membrane and the material surface is not well understood and poorly controlled. Here we demonstrate that by replicating the nanometer-scale hydrophilic-hydrophobic-hydrophilic architecture of transmembrane proteins, artificial “stealth” probes spontaneously insert and anchor within the lipid bilayer core, forming a high-strength interface. These nanometer-scale hydrophobic bands are readily fabricated on metallic probes by functionalizing the exposed sidewall of an ultrathin evaporated Au metal layer rather than by lithography. Penetration and adhesion forces for butanethiol and dodecanethiol functionalized probes were directly measured using atomic force microscopy (AFM) on thick stacks of lipid bilayers to eliminate substrate effects. The penetration dynamics were starkly different for hydrophobic versus hydrophilic probes. Both 5- and 10 nm thick hydrophobically functionalized probes naturally resided within the lipid core, while hydrophilic probes remained in the aqueous region. Surprisingly, the barrier to probe penetration with short butanethiol chains ( E o ,5 nm = 21.8 k b T , E o ,10 nm = 15.3 k b T ) was dramatically higher than longer dodecanethiol chains ( E o ,5 nm = 14.0 k b T , E o ,10 nm = 10.9 k b T ), indicating that molecular mobility and orientation also play a role in addition to hydrophobicity in determining interface stability. These results highlight a new strategy for designing artificial cell interfaces that can nondestructively penetrate the lipid bilayer." @default.
• W2009165045 created "2016-06-24" @default.
• W2009165045 creator A5012210096 @default.
• W2009165045 creator A5067624752 @default.
• W2009165045 date "2010-03-08" @default.
• W2009165045 modified "2023-09-27" @default.
• W2009165045 title "Fusion of biomimetic stealth probes into lipid bilayer cores" @default.
• W2009165045 cites W1972550367 @default.
• W2009165045 cites W1972912510 @default.
• W2009165045 cites W1974683686 @default.
• W2009165045 cites W1981445035 @default.
• W2009165045 cites W1982716000 @default.
• W2009165045 cites W1995732822 @default.
• W2009165045 cites W1998066198 @default.
• W2009165045 cites W2004418610 @default.
• W2009165045 cites W2009177523 @default.
• W2009165045 cites W2017385598 @default.
• W2009165045 cites W2017654210 @default.
• W2009165045 cites W2019877102 @default.
• W2009165045 cites W2021882008 @default.
• W2009165045 cites W2026593599 @default.
• W2009165045 cites W2034945453 @default.
• W2009165045 cites W2040894400 @default.
• W2009165045 cites W2045248457 @default.
• W2009165045 cites W2046890107 @default.
• W2009165045 cites W2048336231 @default.
• W2009165045 cites W2050227428 @default.
• W2009165045 cites W2056648038 @default.
• W2009165045 cites W2057893343 @default.
• W2009165045 cites W2059571424 @default.
• W2009165045 cites W2061814970 @default.
• W2009165045 cites W2063838088 @default.
• W2009165045 cites W2088049591 @default.
• W2009165045 cites W2099482502 @default.
• W2009165045 cites W2101621191 @default.
• W2009165045 cites W2104559182 @default.
• W2009165045 cites W2124158735 @default.
• W2009165045 cites W2128882835 @default.
• W2009165045 cites W2130606072 @default.
• W2009165045 cites W2132936019 @default.
• W2009165045 cites W2139770018 @default.
• W2009165045 cites W2147070227 @default.
• W2009165045 cites W4242601767 @default.
• W2009165045 cites W4244657081 @default.
• W2009165045 doi "https://doi.org/10.1073/pnas.0909250107" @default.
• W2009165045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2851869" @default.
• W2009165045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20212151" @default.
• W2009165045 hasPublicationYear "2010" @default.
• W2009165045 type Work @default.
• W2009165045 sameAs 2009165045 @default.
• W2009165045 citedByCount "87" @default.
• W2009165045 countsByYear W20091650452012 @default.
• W2009165045 countsByYear W20091650452013 @default.
• W2009165045 countsByYear W20091650452014 @default.
• W2009165045 countsByYear W20091650452015 @default.
• W2009165045 countsByYear W20091650452016 @default.
• W2009165045 countsByYear W20091650452017 @default.
• W2009165045 countsByYear W20091650452018 @default.
• W2009165045 countsByYear W20091650452019 @default.
• W2009165045 countsByYear W20091650452020 @default.
• W2009165045 countsByYear W20091650452021 @default.
• W2009165045 countsByYear W20091650452022 @default.
• W2009165045 crossrefType "journal-article" @default.
• W2009165045 hasAuthorship W2009165045A5012210096 @default.
• W2009165045 hasAuthorship W2009165045A5067624752 @default.
• W2009165045 hasBestOaLocation W20091650452 @default.
• W2009165045 hasConcept C12554922 @default.
• W2009165045 hasConcept C127413603 @default.
• W2009165045 hasConcept C171250308 @default.
• W2009165045 hasConcept C185592680 @default.
• W2009165045 hasConcept C192157962 @default.
• W2009165045 hasConcept C192562407 @default.
• W2009165045 hasConcept C39944091 @default.
• W2009165045 hasConcept C41625074 @default.
• W2009165045 hasConcept C42360764 @default.
• W2009165045 hasConcept C42475967 @default.
• W2009165045 hasConcept C55493867 @default.
• W2009165045 hasConcept C80107235 @default.
• W2009165045 hasConcept C86803240 @default.
• W2009165045 hasConceptScore W2009165045C12554922 @default.
• W2009165045 hasConceptScore W2009165045C127413603 @default.
• W2009165045 hasConceptScore W2009165045C171250308 @default.
• W2009165045 hasConceptScore W2009165045C185592680 @default.
• W2009165045 hasConceptScore W2009165045C192157962 @default.
• W2009165045 hasConceptScore W2009165045C192562407 @default.
• W2009165045 hasConceptScore W2009165045C39944091 @default.
• W2009165045 hasConceptScore W2009165045C41625074 @default.
• W2009165045 hasConceptScore W2009165045C42360764 @default.
• W2009165045 hasConceptScore W2009165045C42475967 @default.
• W2009165045 hasConceptScore W2009165045C55493867 @default.
• W2009165045 hasConceptScore W2009165045C80107235 @default.
• W2009165045 hasConceptScore W2009165045C86803240 @default.
• W2009165045 hasIssue "13" @default.
• W2009165045 hasLocation W20091650451 @default.
• W2009165045 hasLocation W20091650452 @default.
• W2009165045 hasLocation W20091650453 @default.
• W2009165045 hasLocation W20091650454 @default.
• W2009165045 hasOpenAccess W2009165045 @default.

• next