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• W2009169193 abstract "Telomeres are specialised structures at the ends of mammalian chromosomes with many unique properties. Recombinational events at telomeres are more frequent than in the remainder of the genome by several orders of magnitude. This study examined the influence of telomerase status and telomere length on genome-wide recombination assessed by genomic sister chromatid exchange (G-SCE). Telomerase deficiency per se appears to increase G-SCE frequencies in splenocytes but as telomeres shorten through subsequent generations of m<i>Terc</i>^–/– mice this increase is progressively lost. Telomerase status and telomere length also influences the induction of G-SCE by UV light. Even when mitotic recombination is affected by PARP deficiency, mTerc and telomere length interact to further affect G-SCE frequencies. Taken together the data presented here demonstrate that telomerase status and telomere length can affect recombination frequencies genome-wide." @default.
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• W2009169193 date "2008-01-01" @default.
• W2009169193 modified "2023-10-18" @default.
• W2009169193 title "A possible role for telomerase RNA and telomere length in global mitotic recombination" @default.
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• W2009169193 doi "https://doi.org/10.1159/000167815" @default.
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