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- W2009171794 abstract "Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARγ is the most extensively studied amongst the three subtypes (α, δ and γ). This receptor is a key modulator of lipid and glucose homeostasis and is predominantly expressed in adipose tissue. Expression of PPARγ is also found in non-adipose tissues including heart, kidney, spleen, and interestingly, in all relevant components of the vasculature: endothelial and smooth muscle cells. These receptors may therefore also play a role in the regulation of vascular tone and blood pressure. Genetic variants of PPARγ have also been associated with features of the metabolic syndrome, including obesity and increased blood pressure. The discovery of synthetic ligands for PPARγ, the Thiazolidinediones (TZDs) has greatly enhanced our understanding of their ligand dependent activation and more importantly their role in vascular pathobiology. Approximately 10 years ago, serendipitous animal experiments demonstrated that despite causing sodium retention, the TZDs actually lowered blood pressure. This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension." @default.
- W2009171794 created "2016-06-24" @default.
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- W2009171794 date "2006-07-01" @default.
- W2009171794 modified "2023-09-23" @default.
- W2009171794 title "Can PPARγ agonists have a role in the management of obesity-related hypertension?" @default.
- W2009171794 cites W1488559297 @default.
- W2009171794 cites W1510126425 @default.
- W2009171794 cites W1832341580 @default.
- W2009171794 cites W1964716328 @default.
- W2009171794 cites W1970295523 @default.
- W2009171794 cites W1975170834 @default.
- W2009171794 cites W1975567521 @default.
- W2009171794 cites W1975974235 @default.
- W2009171794 cites W1980701889 @default.
- W2009171794 cites W1985709687 @default.
- W2009171794 cites W1985948983 @default.
- W2009171794 cites W1991551391 @default.
- W2009171794 cites W1998111567 @default.
- W2009171794 cites W2000379309 @default.
- W2009171794 cites W2001589261 @default.
- W2009171794 cites W2007437966 @default.
- W2009171794 cites W2014922435 @default.
- W2009171794 cites W2021305708 @default.
- W2009171794 cites W2022766726 @default.
- W2009171794 cites W2030973204 @default.
- W2009171794 cites W2036010496 @default.
- W2009171794 cites W2039680101 @default.
- W2009171794 cites W2041864846 @default.
- W2009171794 cites W2042618169 @default.
- W2009171794 cites W2043595406 @default.
- W2009171794 cites W2044548466 @default.
- W2009171794 cites W2047591801 @default.
- W2009171794 cites W2051727048 @default.
- W2009171794 cites W2054851194 @default.
- W2009171794 cites W2077819931 @default.
- W2009171794 cites W2081070477 @default.
- W2009171794 cites W2081846665 @default.
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- W2009171794 doi "https://doi.org/10.1016/j.vph.2005.11.010" @default.
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