Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009173631> ?p ?o ?g. }
- W2009173631 endingPage "4370" @default.
- W2009173631 startingPage "4361" @default.
- W2009173631 abstract "Although reversible phosphorylation on tyrosine residues regulates the activity of many eukaryotic proteins, there are few examples of this type of regulation in bacteria. We have identified the first essential tyrosine phosphatase homolog in a bacterium, Caulobacter crescentus CtpA. ctpA mutants with altered active-site residues are nonviable, and depletion of CtpA yields chains of cells with blebbed outer membranes, linked by unresolved peptidoglycan. CtpA overexpression reduces cell curvature in a manner similar to deleting the intermediate filament protein crescentin, but it does not disrupt crescentin localization or membrane attachment. Although it has no obvious signal sequence or transmembrane-spanning domains, CtpA associates with the Caulobacter inner membrane. Immunolocalization experiments suggest that CtpA accumulates at the division site during the last quarter of the cell cycle. We propose that CtpA dephosphorylates one or more proteins involved in peptidoglycan biosynthesis or remodeling, which in turn affect cell separation, cell envelope integrity, and vibrioid morphology." @default.
- W2009173631 created "2016-06-24" @default.
- W2009173631 creator A5001047864 @default.
- W2009173631 creator A5008289271 @default.
- W2009173631 creator A5070810705 @default.
- W2009173631 creator A5087826409 @default.
- W2009173631 date "2011-09-01" @default.
- W2009173631 modified "2023-09-27" @default.
- W2009173631 title "An Essential Tyrosine Phosphatase Homolog Regulates Cell Separation, Outer Membrane Integrity, and Morphology in Caulobacter crescentus" @default.
- W2009173631 cites W1480333296 @default.
- W2009173631 cites W1496678322 @default.
- W2009173631 cites W1508761218 @default.
- W2009173631 cites W1578364075 @default.
- W2009173631 cites W158273916 @default.
- W2009173631 cites W1594511007 @default.
- W2009173631 cites W1817743640 @default.
- W2009173631 cites W1845620697 @default.
- W2009173631 cites W1876954753 @default.
- W2009173631 cites W1900707388 @default.
- W2009173631 cites W1919928164 @default.
- W2009173631 cites W1922885451 @default.
- W2009173631 cites W1969918683 @default.
- W2009173631 cites W1976030780 @default.
- W2009173631 cites W1976649316 @default.
- W2009173631 cites W1976908689 @default.
- W2009173631 cites W1977922844 @default.
- W2009173631 cites W1981008984 @default.
- W2009173631 cites W1982486689 @default.
- W2009173631 cites W1983494528 @default.
- W2009173631 cites W1985253447 @default.
- W2009173631 cites W1993761203 @default.
- W2009173631 cites W1999986549 @default.
- W2009173631 cites W2005305957 @default.
- W2009173631 cites W2006259476 @default.
- W2009173631 cites W2008093673 @default.
- W2009173631 cites W2025502593 @default.
- W2009173631 cites W2034266027 @default.
- W2009173631 cites W2047119176 @default.
- W2009173631 cites W2050000908 @default.
- W2009173631 cites W2056604835 @default.
- W2009173631 cites W2058933513 @default.
- W2009173631 cites W2060068008 @default.
- W2009173631 cites W2062306301 @default.
- W2009173631 cites W2067972708 @default.
- W2009173631 cites W2070034694 @default.
- W2009173631 cites W2076847722 @default.
- W2009173631 cites W2077128644 @default.
- W2009173631 cites W2077261875 @default.
- W2009173631 cites W2079583942 @default.
- W2009173631 cites W2082110408 @default.
- W2009173631 cites W2082873640 @default.
- W2009173631 cites W2083157138 @default.
- W2009173631 cites W2083885996 @default.
- W2009173631 cites W2089367187 @default.
- W2009173631 cites W2091786047 @default.
- W2009173631 cites W2098854471 @default.
- W2009173631 cites W2100716215 @default.
- W2009173631 cites W2102800671 @default.
- W2009173631 cites W2103691512 @default.
- W2009173631 cites W2109783063 @default.
- W2009173631 cites W2117319600 @default.
- W2009173631 cites W2117772438 @default.
- W2009173631 cites W2121077074 @default.
- W2009173631 cites W2121140171 @default.
- W2009173631 cites W2125376264 @default.
- W2009173631 cites W2127321623 @default.
- W2009173631 cites W2129274971 @default.
- W2009173631 cites W2129379259 @default.
- W2009173631 cites W2131678572 @default.
- W2009173631 cites W2133506867 @default.
- W2009173631 cites W2134165623 @default.
- W2009173631 cites W2136610521 @default.
- W2009173631 cites W2139182107 @default.
- W2009173631 cites W2142009991 @default.
- W2009173631 cites W2148760535 @default.
- W2009173631 cites W2151006034 @default.
- W2009173631 cites W2155463529 @default.
- W2009173631 cites W2155620660 @default.
- W2009173631 cites W2159377012 @default.
- W2009173631 cites W2159920973 @default.
- W2009173631 cites W2163318068 @default.
- W2009173631 cites W2164673267 @default.
- W2009173631 cites W2171723342 @default.
- W2009173631 cites W4295216797 @default.
- W2009173631 cites W950515816 @default.
- W2009173631 doi "https://doi.org/10.1128/jb.00185-11" @default.
- W2009173631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3165520" @default.
- W2009173631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21705597" @default.
- W2009173631 hasPublicationYear "2011" @default.
- W2009173631 type Work @default.
- W2009173631 sameAs 2009173631 @default.
- W2009173631 citedByCount "11" @default.
- W2009173631 countsByYear W20091736312012 @default.
- W2009173631 countsByYear W20091736312013 @default.
- W2009173631 countsByYear W20091736312014 @default.
- W2009173631 countsByYear W20091736312015 @default.
- W2009173631 countsByYear W20091736312017 @default.
- W2009173631 countsByYear W20091736312019 @default.