FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009183417> ?p ?o ?g. }

• W2009183417 endingPage "257" @default.
• W2009183417 startingPage "251" @default.
• W2009183417 abstract "MicroRNAs (miRNAs) are noncoding RNAs with specific regulatory role in gene expression. Recent reports suggested their involvement in human malignancies. Currently, there is no information concerning miRNA expression and functions in squamous cell carcinoma (SCC) of tongue. In this study, we evaluated the expression patterns of 156 mature miRNAs in tongue SCC using Taqman-based microRNA assays. Of these 156 miRNAs, miR-133a and miR-133b were significantly reduced in tongue SCC cells in comparison with the paired normal epithelial cells. Tongue SCC cell lines transfected with miR-133a and miR-133b precursors displayed reduction in proliferation rate. In addition, the number of apoptotic cells was increased in response to the introduction of precursors. Computational target gene prediction suggested that both miR-133a and miR-133b are targeting transcript of pyruvate kinase type M2 (PKM2), a potential oncogene in solid cancers. In tongue SCC cell lines, PKM2 expression was reduced in response to miR-133a and miR-133b precursors transfection. Immunohistochemical staining results of tongue SCC tissues suggested that PKM2 was overexpressed in tongue SCC and was associated with the downregulation of miR-133a and miR-133b. Our results suggested that aberrant reduction of miR-133a and miR-133b was associated with the dysregulation of PKM2 in SCC of tongue. © 2008 Wiley-Liss, Inc." @default.
• W2009183417 created "2016-06-24" @default.
• W2009183417 creator A5005817721 @default.
• W2009183417 creator A5053216933 @default.
• W2009183417 creator A5064357077 @default.
• W2009183417 creator A5071411952 @default.
• W2009183417 creator A5088738197 @default.
• W2009183417 creator A5089551397 @default.
• W2009183417 date "2008-05-07" @default.
• W2009183417 modified "2023-10-03" @default.
• W2009183417 title "Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling" @default.
• W2009183417 cites W1541248931 @default.
• W2009183417 cites W1767992000 @default.
• W2009183417 cites W1985563073 @default.
• W2009183417 cites W1992501118 @default.
• W2009183417 cites W1995584848 @default.
• W2009183417 cites W2000904576 @default.
• W2009183417 cites W2008022352 @default.
• W2009183417 cites W2030322070 @default.
• W2009183417 cites W2044004072 @default.
• W2009183417 cites W2045730497 @default.
• W2009183417 cites W2046997068 @default.
• W2009183417 cites W2050066317 @default.
• W2009183417 cites W2081119041 @default.
• W2009183417 cites W2087339923 @default.
• W2009183417 cites W2101238761 @default.
• W2009183417 cites W2112371447 @default.
• W2009183417 cites W2112560790 @default.
• W2009183417 cites W2122638544 @default.
• W2009183417 cites W2153246510 @default.
• W2009183417 cites W2164687768 @default.
• W2009183417 cites W2405568717 @default.
• W2009183417 cites W269495507 @default.
• W2009183417 doi "https://doi.org/10.1002/ijc.23583" @default.
• W2009183417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18464261" @default.
• W2009183417 hasPublicationYear "2008" @default.
• W2009183417 type Work @default.
• W2009183417 sameAs 2009183417 @default.
• W2009183417 citedByCount "169" @default.
• W2009183417 countsByYear W20091834172012 @default.
• W2009183417 countsByYear W20091834172013 @default.
• W2009183417 countsByYear W20091834172014 @default.
• W2009183417 countsByYear W20091834172015 @default.
• W2009183417 countsByYear W20091834172016 @default.
• W2009183417 countsByYear W20091834172017 @default.
• W2009183417 countsByYear W20091834172018 @default.
• W2009183417 countsByYear W20091834172019 @default.
• W2009183417 countsByYear W20091834172020 @default.
• W2009183417 countsByYear W20091834172021 @default.
• W2009183417 countsByYear W20091834172022 @default.
• W2009183417 countsByYear W20091834172023 @default.
• W2009183417 crossrefType "journal-article" @default.
• W2009183417 hasAuthorship W2009183417A5005817721 @default.
• W2009183417 hasAuthorship W2009183417A5053216933 @default.
• W2009183417 hasAuthorship W2009183417A5064357077 @default.
• W2009183417 hasAuthorship W2009183417A5071411952 @default.
• W2009183417 hasAuthorship W2009183417A5088738197 @default.
• W2009183417 hasAuthorship W2009183417A5089551397 @default.
• W2009183417 hasBestOaLocation W20091834171 @default.
• W2009183417 hasConcept C104317684 @default.
• W2009183417 hasConcept C10730799 @default.
• W2009183417 hasConcept C134018914 @default.
• W2009183417 hasConcept C142724271 @default.
• W2009183417 hasConcept C145059251 @default.
• W2009183417 hasConcept C1491633281 @default.
• W2009183417 hasConcept C20251656 @default.
• W2009183417 hasConcept C2779744641 @default.
• W2009183417 hasConcept C2780854706 @default.
• W2009183417 hasConcept C2781018059 @default.
• W2009183417 hasConcept C29537977 @default.
• W2009183417 hasConcept C502942594 @default.
• W2009183417 hasConcept C54009773 @default.
• W2009183417 hasConcept C54355233 @default.
• W2009183417 hasConcept C62112901 @default.
• W2009183417 hasConcept C62231903 @default.
• W2009183417 hasConcept C71924100 @default.
• W2009183417 hasConcept C81885089 @default.
• W2009183417 hasConcept C86803240 @default.
• W2009183417 hasConceptScore W2009183417C104317684 @default.
• W2009183417 hasConceptScore W2009183417C10730799 @default.
• W2009183417 hasConceptScore W2009183417C134018914 @default.
• W2009183417 hasConceptScore W2009183417C142724271 @default.
• W2009183417 hasConceptScore W2009183417C145059251 @default.
• W2009183417 hasConceptScore W2009183417C1491633281 @default.
• W2009183417 hasConceptScore W2009183417C20251656 @default.
• W2009183417 hasConceptScore W2009183417C2779744641 @default.
• W2009183417 hasConceptScore W2009183417C2780854706 @default.
• W2009183417 hasConceptScore W2009183417C2781018059 @default.
• W2009183417 hasConceptScore W2009183417C29537977 @default.
• W2009183417 hasConceptScore W2009183417C502942594 @default.
• W2009183417 hasConceptScore W2009183417C54009773 @default.
• W2009183417 hasConceptScore W2009183417C54355233 @default.
• W2009183417 hasConceptScore W2009183417C62112901 @default.
• W2009183417 hasConceptScore W2009183417C62231903 @default.
• W2009183417 hasConceptScore W2009183417C71924100 @default.
• W2009183417 hasConceptScore W2009183417C81885089 @default.
• W2009183417 hasConceptScore W2009183417C86803240 @default.
• W2009183417 hasIssue "2" @default.

• next