FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009183996> ?p ?o ?g. }

• W2009183996 endingPage "659" @default.
• W2009183996 startingPage "651" @default.
• W2009183996 abstract "The blood coagulation system is activated regularly in severe forms of shock, polytrauma, and sepsis. Arising thrombin cleaves the fibrinopeptides A and B from fibrinogen, and it generates monomers of fibrin, which are initially kept in solution by the remaining excess fibrinogen. The effects of soluble fibrin (fibrin monomer/oligomer-fibrinogen complexes) and fibrinopeptides A and B were investigated in blood-free perfused, isolated rabbit lungs. Urea Tris buffer-dissolved fibrin monomers were injected into the pulmonary artery in the presence of circulating excess fibrinogen. In doses above 5 mg, the monomers consistently provoked a sharp rise in pulmonary artery pressure, which was followed by an elevated pressure plateau. Changing to fresh perfusate devoid of soluble fibrin did not restore the pressure to baseline, and a second administration of the soluble fibrin caused a pressor response larger than the first. Only a modest increase in lung weight (less than 2 g) was observed, and lung inflation pressure was not altered. The pressor responses were accompanied by a rapid release of thromboxane A2 and a more delayed release of prostaglandin I2 into the perfusion fluid. A significant correlation between the height of the fibrin-induced pressure rise and the amount of thromboxane release was noted. Inhibition of cyclooxygenase (indomethacin) suppressed the generation of both prostanoids, whereas inhibition of thromboxane synthetase (OKY-046 and imidazole) selectively blocked the liberation of thromboxane. All three inhibitors caused an immediate decline in pulmonary artery pressure, which had been previously elevated due to administration of soluble fibrin, and markedly reduced the pressor response evoked by a subsequent fibrin application in the same lung.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2009183996 created "2016-06-24" @default.
• W2009183996 creator A5016511599 @default.
• W2009183996 creator A5034067228 @default.
• W2009183996 creator A5060783502 @default.
• W2009183996 creator A5071061522 @default.
• W2009183996 date "1988-04-01" @default.
• W2009183996 modified "2023-10-18" @default.
• W2009183996 title "Pulmonary vasoconstrictor response to soluble fibrin in isolated lungs: possible role of thromboxane generation." @default.
• W2009183996 cites W1507512048 @default.
• W2009183996 cites W1509128721 @default.
• W2009183996 cites W1583078067 @default.
• W2009183996 cites W1596275045 @default.
• W2009183996 cites W1974152644 @default.
• W2009183996 cites W1980342270 @default.
• W2009183996 cites W1981454935 @default.
• W2009183996 cites W1985734827 @default.
• W2009183996 cites W1989747719 @default.
• W2009183996 cites W1991618418 @default.
• W2009183996 cites W1993298615 @default.
• W2009183996 cites W1994683149 @default.
• W2009183996 cites W1994978821 @default.
• W2009183996 cites W1998836103 @default.
• W2009183996 cites W1999030808 @default.
• W2009183996 cites W2004829500 @default.
• W2009183996 cites W2012743116 @default.
• W2009183996 cites W2013118448 @default.
• W2009183996 cites W2015462397 @default.
• W2009183996 cites W2018578444 @default.
• W2009183996 cites W2027420749 @default.
• W2009183996 cites W2028381044 @default.
• W2009183996 cites W2030003966 @default.
• W2009183996 cites W2041528637 @default.
• W2009183996 cites W2042722294 @default.
• W2009183996 cites W2048212499 @default.
• W2009183996 cites W2058697385 @default.
• W2009183996 cites W2058994566 @default.
• W2009183996 cites W2063835893 @default.
• W2009183996 cites W2075365621 @default.
• W2009183996 cites W2082598893 @default.
• W2009183996 cites W2084525357 @default.
• W2009183996 cites W2085438086 @default.
• W2009183996 cites W2086656789 @default.
• W2009183996 cites W2092445473 @default.
• W2009183996 cites W2117944649 @default.
• W2009183996 cites W2119968334 @default.
• W2009183996 cites W2123708308 @default.
• W2009183996 cites W2131217574 @default.
• W2009183996 cites W2155310241 @default.
• W2009183996 cites W2159141216 @default.
• W2009183996 cites W2161149721 @default.
• W2009183996 cites W2206615847 @default.
• W2009183996 cites W2280036817 @default.
• W2009183996 cites W2410005309 @default.
• W2009183996 cites W2413229645 @default.
• W2009183996 cites W2417435811 @default.
• W2009183996 cites W2418743515 @default.
• W2009183996 cites W2509800920 @default.
• W2009183996 cites W2520570369 @default.
• W2009183996 cites W4248870929 @default.
• W2009183996 doi "https://doi.org/10.1161/01.res.62.4.651" @default.
• W2009183996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3349571" @default.
• W2009183996 hasPublicationYear "1988" @default.
• W2009183996 type Work @default.
• W2009183996 sameAs 2009183996 @default.
• W2009183996 citedByCount "18" @default.
• W2009183996 countsByYear W20091839962020 @default.
• W2009183996 crossrefType "journal-article" @default.
• W2009183996 hasAuthorship W2009183996A5016511599 @default.
• W2009183996 hasAuthorship W2009183996A5034067228 @default.
• W2009183996 hasAuthorship W2009183996A5060783502 @default.
• W2009183996 hasAuthorship W2009183996A5071061522 @default.
• W2009183996 hasBestOaLocation W20091839961 @default.
• W2009183996 hasConcept C126322002 @default.
• W2009183996 hasConcept C134018914 @default.
• W2009183996 hasConcept C181199279 @default.
• W2009183996 hasConcept C185592680 @default.
• W2009183996 hasConcept C203014093 @default.
• W2009183996 hasConcept C2776785769 @default.
• W2009183996 hasConcept C2777292125 @default.
• W2009183996 hasConcept C2779036427 @default.
• W2009183996 hasConcept C2779689624 @default.
• W2009183996 hasConcept C2781024287 @default.
• W2009183996 hasConcept C2781080829 @default.
• W2009183996 hasConcept C2781300812 @default.
• W2009183996 hasConcept C54173615 @default.
• W2009183996 hasConcept C55493867 @default.
• W2009183996 hasConcept C71924100 @default.
• W2009183996 hasConcept C89560881 @default.
• W2009183996 hasConcept C98274493 @default.
• W2009183996 hasConceptScore W2009183996C126322002 @default.
• W2009183996 hasConceptScore W2009183996C134018914 @default.
• W2009183996 hasConceptScore W2009183996C181199279 @default.
• W2009183996 hasConceptScore W2009183996C185592680 @default.
• W2009183996 hasConceptScore W2009183996C203014093 @default.
• W2009183996 hasConceptScore W2009183996C2776785769 @default.
• W2009183996 hasConceptScore W2009183996C2777292125 @default.
• W2009183996 hasConceptScore W2009183996C2779036427 @default.

• next