FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009192012> ?p ?o ?g. }

• W2009192012 endingPage "31" @default.
• W2009192012 startingPage "25" @default.
• W2009192012 abstract "The positive association of decreased risk of colorectal cancer with nonsteroidal antiinflammatory drug (NSAID) use, combined with the observation that cyclooxygenase(COX)-2 is present in a majority of colorectal tumors, has led to the proposed use of isozyme-specific COX inhibitors as preventive agents in polyp and tumor formation in the colon. However, the exact biochemical mechanisms and disease stage at which reduced risk is mediated remain somewhat controversial, in part because of the complex biochemical changes that occur during the progression from aberrant crypt to polyp to tumor. In this study, COX-1 and COX-2 protein expression levels were determined in sets of tumor and normal colon tissue. Changes were characterized in COX-1 and COX-2 expression within individuals, in relation to such factors as sex, tumor grade, and location in the colorectum. COX-1 expression levels were found to be significantly reduced in tumors compared to matched normal tissues (Dunn's method, P < 0.05). Additionally, COX-1 expression was decreased in stage T3 tumors as compared to stage T2 tumors (Student's t-test, P = 0.009). Similar to previous reports, COX-2 protein expression was present in 73% of the tumors studied and appeared to be independent of tumor grade and sex. Interestingly, decreased COX-2 expression correlated with tumor occurrence in rectal mucosa (Wilcoxon two-sample test, P < 0.05). These results warrant further investigation, especially the identification of determinants that would predict which populations would be most responsive to COX-2 inhibition as a means of colorectal cancer chemoprevention." @default.
• W2009192012 created "2016-06-24" @default.
• W2009192012 creator A5000845552 @default.
• W2009192012 creator A5012800731 @default.
• W2009192012 creator A5029541691 @default.
• W2009192012 creator A5051576299 @default.
• W2009192012 creator A5066095968 @default.
• W2009192012 creator A5087771359 @default.
• W2009192012 date "2003-04-23" @default.
• W2009192012 modified "2023-09-25" @default.
• W2009192012 title "Variation in cyclooxygenase expression levels within the colorectum" @default.
• W2009192012 cites W1506043065 @default.
• W2009192012 cites W1515368864 @default.
• W2009192012 cites W1536681507 @default.
• W2009192012 cites W1987512948 @default.
• W2009192012 cites W2004724470 @default.
• W2009192012 cites W2021415747 @default.
• W2009192012 cites W2024289681 @default.
• W2009192012 cites W2040528315 @default.
• W2009192012 cites W2041777500 @default.
• W2009192012 cites W2043707891 @default.
• W2009192012 cites W2051686420 @default.
• W2009192012 cites W2083917519 @default.
• W2009192012 cites W2097997344 @default.
• W2009192012 cites W2100837269 @default.
• W2009192012 cites W2101108802 @default.
• W2009192012 cites W2112846006 @default.
• W2009192012 cites W2113365544 @default.
• W2009192012 cites W2115424486 @default.
• W2009192012 cites W2116102795 @default.
• W2009192012 cites W2127558096 @default.
• W2009192012 cites W2158743409 @default.
• W2009192012 cites W2330709704 @default.
• W2009192012 cites W2336215030 @default.
• W2009192012 doi "https://doi.org/10.1002/mc.10115" @default.
• W2009192012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12720297" @default.
• W2009192012 hasPublicationYear "2003" @default.
• W2009192012 type Work @default.
• W2009192012 sameAs 2009192012 @default.
• W2009192012 citedByCount "23" @default.
• W2009192012 countsByYear W20091920122015 @default.
• W2009192012 countsByYear W20091920122017 @default.
• W2009192012 countsByYear W20091920122018 @default.
• W2009192012 countsByYear W20091920122020 @default.
• W2009192012 countsByYear W20091920122021 @default.
• W2009192012 crossrefType "journal-article" @default.
• W2009192012 hasAuthorship W2009192012A5000845552 @default.
• W2009192012 hasAuthorship W2009192012A5012800731 @default.
• W2009192012 hasAuthorship W2009192012A5029541691 @default.
• W2009192012 hasAuthorship W2009192012A5051576299 @default.
• W2009192012 hasAuthorship W2009192012A5066095968 @default.
• W2009192012 hasAuthorship W2009192012A5087771359 @default.
• W2009192012 hasConcept C119795356 @default.
• W2009192012 hasConcept C121608353 @default.
• W2009192012 hasConcept C126322002 @default.
• W2009192012 hasConcept C134018914 @default.
• W2009192012 hasConcept C142724271 @default.
• W2009192012 hasConcept C143998085 @default.
• W2009192012 hasConcept C181199279 @default.
• W2009192012 hasConcept C2779689624 @default.
• W2009192012 hasConcept C502942594 @default.
• W2009192012 hasConcept C50382708 @default.
• W2009192012 hasConcept C526805850 @default.
• W2009192012 hasConcept C55493867 @default.
• W2009192012 hasConcept C555283112 @default.
• W2009192012 hasConcept C66090201 @default.
• W2009192012 hasConcept C71924100 @default.
• W2009192012 hasConcept C86803240 @default.
• W2009192012 hasConceptScore W2009192012C119795356 @default.
• W2009192012 hasConceptScore W2009192012C121608353 @default.
• W2009192012 hasConceptScore W2009192012C126322002 @default.
• W2009192012 hasConceptScore W2009192012C134018914 @default.
• W2009192012 hasConceptScore W2009192012C142724271 @default.
• W2009192012 hasConceptScore W2009192012C143998085 @default.
• W2009192012 hasConceptScore W2009192012C181199279 @default.
• W2009192012 hasConceptScore W2009192012C2779689624 @default.
• W2009192012 hasConceptScore W2009192012C502942594 @default.
• W2009192012 hasConceptScore W2009192012C50382708 @default.
• W2009192012 hasConceptScore W2009192012C526805850 @default.
• W2009192012 hasConceptScore W2009192012C55493867 @default.
• W2009192012 hasConceptScore W2009192012C555283112 @default.
• W2009192012 hasConceptScore W2009192012C66090201 @default.
• W2009192012 hasConceptScore W2009192012C71924100 @default.
• W2009192012 hasConceptScore W2009192012C86803240 @default.
• W2009192012 hasIssue "1" @default.
• W2009192012 hasLocation W20091920121 @default.
• W2009192012 hasLocation W20091920122 @default.
• W2009192012 hasOpenAccess W2009192012 @default.
• W2009192012 hasPrimaryLocation W20091920121 @default.
• W2009192012 hasRelatedWork W1499339123 @default.
• W2009192012 hasRelatedWork W2028850353 @default.
• W2009192012 hasRelatedWork W2062380899 @default.
• W2009192012 hasRelatedWork W2117059884 @default.
• W2009192012 hasRelatedWork W2333741020 @default.
• W2009192012 hasRelatedWork W2361884956 @default.
• W2009192012 hasRelatedWork W2542604898 @default.
• W2009192012 hasRelatedWork W2769390123 @default.
• W2009192012 hasRelatedWork W3116400448 @default.

• next