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- W2009200360 abstract "A central question in insect chemoreception is whether signaling occurs via G-proteins. Two families of seven-transmembrane-domain chemoreceptors, the odor (Or) and gustatory receptor (Gr) families, have been identified in Drosophila (Clyne et al., 1999, 2000; Vosshall et al., 1999). Ors mediate odor responses, whereas two Grs, Gr21a and Gr63a, mediate CO 2 response (Hallem et al., 2004; Jones et al., 2007; Kwon et al., 2007). Using single-sensillum recordings, we systematically investigate the role of Gα proteins in vivo , initially with RNA interference constructs, competitive peptides, and constitutively active Gα proteins. The results do not support a role for Gα proteins in odor sensitivity. In parallel experiments, manipulations of Gα q , but not other Gα proteins, affected CO 2 response. Transient, conditional, and ectopic expression analyses consistently supported a role for Gα q in the response of CO 2 -sensing neurons, but not odor-sensing neurons. Genetic mosaic analysis confirmed that odor responses are normal in the absence of Gα q . Gγ30A is also required for normal CO 2 response. The simplest interpretation of these results is that Gα q and Gγ30A play a role in the response of CO 2 -sensing neurons, but are not required for Or-mediated odor signaling." @default.
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- W2009200360 date "2010-03-31" @default.
- W2009200360 modified "2023-09-25" @default.
- W2009200360 title "Role of G-Proteins in Odor-Sensing and CO<sub>2</sub>-Sensing Neurons in Drosophila" @default.
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- W2009200360 doi "https://doi.org/10.1523/jneurosci.6357-09.2010" @default.
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