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- W2009207148 abstract "Angiotensin II receptors are diverse and mediate complex signaling mechanisms. Their isoforms AT1 and AT2 have been cloned. AT1 consists of two closely related subtypes, AT1A and AT1B, in rodents. AT1A is expressed preferentially in the kidney, liver and cardiovascular tissues, whereas, AT1B is found mainly in endocrine tissues like the adrenal and pituitary glands. In higher mammals only a single isoform of AT1 has been reported. AT1 accounts for the majority of actions traditionally ascribed to angiotensin II that include the Gq-protein coupled activation of phospholipase C, Gi-coupled opening of an L-type calcium channel. AT2 was cloned recently from rat tissues and cell lines. It has a structure compatible with a seven transmembrane domain receptor in spite of the lack of internalization or shift to the low affinity state by stable GTP analogs. AT2 was found to inhibit certain phosphotyrosine phosphatase(s) by a pertussis toxin-sensitive mechanism. These cloned cDNAs and their mutated cDNAs have been expressed in mammalian cells to identify various functional domains such as ligand binding sites, domains for interaction with various G-proteins, and for desensitization. Both AT1 and AT2 genes consist of 3-5 exons. Their coding regions are contained in a single exon. Angiotensin II down-regulates the expression of the AT1 gene by two different mechanisms, whereas, glucocorticoids up-regulates it. (Hypertens Res 1994; 17:87-97)" @default.
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- W2009207148 title "Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation." @default.
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- W2009207148 doi "https://doi.org/10.1291/hypres.17.87" @default.
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