FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009208082> ?p ?o ?g. }

• W2009208082 endingPage "4724" @default.
• W2009208082 startingPage "4717" @default.
• W2009208082 abstract "The tectorial membrane (TM) has a significantly larger stiffness in the radial direction than other directions, a prominent mechanical anisotropy that is believed to be critical for the proper functioning of the cochlea. To determine the molecular basis of this anisotropy, we measured material properties of TMs from mice with a targeted deletion of Col11a2, which encodes for collagen XI. In light micrographs, the density of TM radial collagen fibers was lower in Col11a2 -/- mice than wild-types. Tone-evoked distortion product otoacoustic emission and auditory brainstem response measurements in Col11a2 -/- mice were reduced by 30-50 dB independent of frequency as compared with wild-types, showing that the sensitivity loss is cochlear in origin. Stress-strain measurements made using osmotic pressure revealed no significant dependence of TM bulk compressibility on the presence of collagen XI. Charge measurements made by placing the TM as an electrical conduit between two baths revealed no change in the density of charge affixed to the TM matrix in Col11a2 -/- mice. Measurements of mechanical shear impedance revealed a 5.5 +/- 0.8 dB decrease in radial shear impedance and a 3.3 +/- 0.3 dB decrease in longitudinal shear impedance resulting from the Col11a2 deletion. The ratio of radial to longitudinal shear impedance fell from 1.8 +/- 0.7 for TMs from wild-type mice to 1.0 +/- 0.1 for those from Col11a2 -/- mice. These results show that the organization of collagen into radial fibrils is responsible for the mechanical anisotropy of the TM. This anisotropy can be attributed to increased mechanical coupling provided by the collagen fibrils. Mechanisms by which changes in TM material properties may contribute to the threshold elevation in Col11a2 -/- mice are discussed." @default.
• W2009208082 created "2016-06-24" @default.
• W2009208082 creator A5014833790 @default.
• W2009208082 creator A5023220106 @default.
• W2009208082 creator A5036835077 @default.
• W2009208082 creator A5042007857 @default.
• W2009208082 creator A5047743381 @default.
• W2009208082 creator A5066396972 @default.
• W2009208082 creator A5070711751 @default.
• W2009208082 date "2009-06-01" @default.
• W2009208082 modified "2023-09-30" @default.
• W2009208082 title "Col11a2 Deletion Reveals the Molecular Basis for Tectorial Membrane Mechanical Anisotropy" @default.
• W2009208082 cites W1966300809 @default.
• W2009208082 cites W1969365560 @default.
• W2009208082 cites W1973343738 @default.
• W2009208082 cites W1973655822 @default.
• W2009208082 cites W1981511407 @default.
• W2009208082 cites W1988579060 @default.
• W2009208082 cites W1995586466 @default.
• W2009208082 cites W1997749289 @default.
• W2009208082 cites W2001653853 @default.
• W2009208082 cites W2002134957 @default.
• W2009208082 cites W2003325145 @default.
• W2009208082 cites W2012937237 @default.
• W2009208082 cites W2017258893 @default.
• W2009208082 cites W2031153627 @default.
• W2009208082 cites W2037093113 @default.
• W2009208082 cites W2039130308 @default.
• W2009208082 cites W2041601646 @default.
• W2009208082 cites W2052331876 @default.
• W2009208082 cites W2056781179 @default.
• W2009208082 cites W2059107906 @default.
• W2009208082 cites W2062780207 @default.
• W2009208082 cites W2063076030 @default.
• W2009208082 cites W2063082352 @default.
• W2009208082 cites W2063341353 @default.
• W2009208082 cites W2064022796 @default.
• W2009208082 cites W2078744277 @default.
• W2009208082 cites W2094434974 @default.
• W2009208082 cites W2132627518 @default.
• W2009208082 cites W2140018191 @default.
• W2009208082 cites W2140114390 @default.
• W2009208082 cites W2144602486 @default.
• W2009208082 cites W2170077801 @default.
• W2009208082 cites W2179278902 @default.
• W2009208082 cites W4246661769 @default.
• W2009208082 cites W4327635065 @default.
• W2009208082 doi "https://doi.org/10.1016/j.bpj.2009.02.056" @default.
• W2009208082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2711449" @default.
• W2009208082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19486694" @default.
• W2009208082 hasPublicationYear "2009" @default.
• W2009208082 type Work @default.
• W2009208082 sameAs 2009208082 @default.
• W2009208082 citedByCount "21" @default.
• W2009208082 countsByYear W20092080822012 @default.
• W2009208082 countsByYear W20092080822013 @default.
• W2009208082 countsByYear W20092080822014 @default.
• W2009208082 countsByYear W20092080822015 @default.
• W2009208082 countsByYear W20092080822017 @default.
• W2009208082 countsByYear W20092080822018 @default.
• W2009208082 countsByYear W20092080822019 @default.
• W2009208082 countsByYear W20092080822020 @default.
• W2009208082 countsByYear W20092080822021 @default.
• W2009208082 countsByYear W20092080822022 @default.
• W2009208082 crossrefType "journal-article" @default.
• W2009208082 hasAuthorship W2009208082A5014833790 @default.
• W2009208082 hasAuthorship W2009208082A5023220106 @default.
• W2009208082 hasAuthorship W2009208082A5036835077 @default.
• W2009208082 hasAuthorship W2009208082A5042007857 @default.
• W2009208082 hasAuthorship W2009208082A5047743381 @default.
• W2009208082 hasAuthorship W2009208082A5066396972 @default.
• W2009208082 hasAuthorship W2009208082A5070711751 @default.
• W2009208082 hasBestOaLocation W20092080821 @default.
• W2009208082 hasConcept C105702510 @default.
• W2009208082 hasConcept C120665830 @default.
• W2009208082 hasConcept C121332964 @default.
• W2009208082 hasConcept C12554922 @default.
• W2009208082 hasConcept C185592680 @default.
• W2009208082 hasConcept C192562407 @default.
• W2009208082 hasConcept C2780130748 @default.
• W2009208082 hasConcept C2780807236 @default.
• W2009208082 hasConcept C2781459932 @default.
• W2009208082 hasConcept C46141821 @default.
• W2009208082 hasConcept C85725439 @default.
• W2009208082 hasConcept C86803240 @default.
• W2009208082 hasConceptScore W2009208082C105702510 @default.
• W2009208082 hasConceptScore W2009208082C120665830 @default.
• W2009208082 hasConceptScore W2009208082C121332964 @default.
• W2009208082 hasConceptScore W2009208082C12554922 @default.
• W2009208082 hasConceptScore W2009208082C185592680 @default.
• W2009208082 hasConceptScore W2009208082C192562407 @default.
• W2009208082 hasConceptScore W2009208082C2780130748 @default.
• W2009208082 hasConceptScore W2009208082C2780807236 @default.
• W2009208082 hasConceptScore W2009208082C2781459932 @default.
• W2009208082 hasConceptScore W2009208082C46141821 @default.
• W2009208082 hasConceptScore W2009208082C85725439 @default.
• W2009208082 hasConceptScore W2009208082C86803240 @default.
• W2009208082 hasIssue "11" @default.

• next