FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009208627> ?p ?o ?g. }

• W2009208627 endingPage "413" @default.
• W2009208627 startingPage "404" @default.
• W2009208627 abstract "We have explored a role for the adenovirus (Ad5) E1b58kDa/p53 protein complex in adenovirus replication. This was done by using virus mutants containing different defects in the E1b58kDa gene and cell lines that express either a wild-type p53 protein or a mutant p53 protein. We find that infection of wild-type p53-containing cells with wild-type Ad5 causes a shutoff of p53 and α-actin protein synthesis by distinct mechanisms, but neither occurs in mutant p53 cells. Our data also indicate that the shutoff is dependent on formation of the p53/E1b complex and may also involve another virus protein, E4ORF6. Following from these observations we asked whether failure to form the complex resulted in impaired adenovirus replication. Our experiments showed that neither wild-type Ad5 nor the E1b mutant dl338 could replicate in cells expressing a mutant p53 protein, but that wild-type adenovirus replicated well in wild-type p53-expressing cells. Collectively, our data suggest that the interaction between p53 and the E1b58kDa protein is necessary for efficient adenovirus replication. This is the first time such a direct link between the complex and virus replication has been demonstrated. These data raise serious questions about the usefulness of E1b-defective viruses in tumor therapy." @default.
• W2009208627 created "2016-06-24" @default.
• W2009208627 creator A5023876984 @default.
• W2009208627 creator A5029629862 @default.
• W2009208627 creator A5063944693 @default.
• W2009208627 creator A5089702268 @default.
• W2009208627 date "1997-10-01" @default.
• W2009208627 modified "2023-09-27" @default.
• W2009208627 title "p53/E1b58kDa Complex Regulates Adenovirus Replication" @default.
• W2009208627 cites W135925168 @default.
• W2009208627 cites W1494490000 @default.
• W2009208627 cites W1497064480 @default.
• W2009208627 cites W1517251498 @default.
• W2009208627 cites W1581105610 @default.
• W2009208627 cites W1602517735 @default.
• W2009208627 cites W1846936111 @default.
• W2009208627 cites W1890770000 @default.
• W2009208627 cites W1923029402 @default.
• W2009208627 cites W1923756169 @default.
• W2009208627 cites W1926037744 @default.
• W2009208627 cites W1933950034 @default.
• W2009208627 cites W1956017529 @default.
• W2009208627 cites W1958548619 @default.
• W2009208627 cites W1965080968 @default.
• W2009208627 cites W1967404701 @default.
• W2009208627 cites W1977041491 @default.
• W2009208627 cites W1978834861 @default.
• W2009208627 cites W1980066350 @default.
• W2009208627 cites W1983971803 @default.
• W2009208627 cites W1999614623 @default.
• W2009208627 cites W2013050540 @default.
• W2009208627 cites W2013752620 @default.
• W2009208627 cites W2016080258 @default.
• W2009208627 cites W2021617274 @default.
• W2009208627 cites W2028143792 @default.
• W2009208627 cites W2039382131 @default.
• W2009208627 cites W2044296969 @default.
• W2009208627 cites W2048850933 @default.
• W2009208627 cites W2060490849 @default.
• W2009208627 cites W2067198866 @default.
• W2009208627 cites W2080633751 @default.
• W2009208627 cites W2097486682 @default.
• W2009208627 cites W2104693664 @default.
• W2009208627 cites W2123449896 @default.
• W2009208627 cites W2134871100 @default.
• W2009208627 cites W2135192417 @default.
• W2009208627 cites W2137745922 @default.
• W2009208627 cites W2141109683 @default.
• W2009208627 cites W2145687705 @default.
• W2009208627 cites W2149256718 @default.
• W2009208627 cites W2163618124 @default.
• W2009208627 cites W2408320845 @default.
• W2009208627 cites W4235071744 @default.
• W2009208627 cites W80648895 @default.
• W2009208627 doi "https://doi.org/10.1006/viro.1997.8782" @default.
• W2009208627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9356351" @default.
• W2009208627 hasPublicationYear "1997" @default.
• W2009208627 type Work @default.
• W2009208627 sameAs 2009208627 @default.
• W2009208627 citedByCount "31" @default.
• W2009208627 countsByYear W20092086272013 @default.
• W2009208627 countsByYear W20092086272015 @default.
• W2009208627 countsByYear W20092086272017 @default.
• W2009208627 countsByYear W20092086272018 @default.
• W2009208627 crossrefType "journal-article" @default.
• W2009208627 hasAuthorship W2009208627A5023876984 @default.
• W2009208627 hasAuthorship W2009208627A5029629862 @default.
• W2009208627 hasAuthorship W2009208627A5063944693 @default.
• W2009208627 hasAuthorship W2009208627A5089702268 @default.
• W2009208627 hasBestOaLocation W20092086271 @default.
• W2009208627 hasConcept C104317684 @default.
• W2009208627 hasConcept C111599444 @default.
• W2009208627 hasConcept C140704245 @default.
• W2009208627 hasConcept C143065580 @default.
• W2009208627 hasConcept C153911025 @default.
• W2009208627 hasConcept C159047783 @default.
• W2009208627 hasConcept C180196505 @default.
• W2009208627 hasConcept C207583985 @default.
• W2009208627 hasConcept C2522874641 @default.
• W2009208627 hasConcept C2776954459 @default.
• W2009208627 hasConcept C2777046247 @default.
• W2009208627 hasConcept C54355233 @default.
• W2009208627 hasConcept C81885089 @default.
• W2009208627 hasConcept C86803240 @default.
• W2009208627 hasConcept C95444343 @default.
• W2009208627 hasConceptScore W2009208627C104317684 @default.
• W2009208627 hasConceptScore W2009208627C111599444 @default.
• W2009208627 hasConceptScore W2009208627C140704245 @default.
• W2009208627 hasConceptScore W2009208627C143065580 @default.
• W2009208627 hasConceptScore W2009208627C153911025 @default.
• W2009208627 hasConceptScore W2009208627C159047783 @default.
• W2009208627 hasConceptScore W2009208627C180196505 @default.
• W2009208627 hasConceptScore W2009208627C207583985 @default.
• W2009208627 hasConceptScore W2009208627C2522874641 @default.
• W2009208627 hasConceptScore W2009208627C2776954459 @default.
• W2009208627 hasConceptScore W2009208627C2777046247 @default.
• W2009208627 hasConceptScore W2009208627C54355233 @default.
• W2009208627 hasConceptScore W2009208627C81885089 @default.

• next