FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009220815> ?p ?o ?g. }

• W2009220815 endingPage "24" @default.
• W2009220815 startingPage "18" @default.
• W2009220815 abstract "Levonorgestrel (LNG) is a commonly used pharmaceutical progestin found in the environment. Information on the long-term toxicity of progestins following early life exposure is scant. We investigated the effects of developmental LNG exposure on sex differentiation, reproductive organ development and fertility in the model frog Xenopus tropicalis. Tadpoles were exposed to 0, 0.06 or 0.5 nM LNG via the water from hatching until metamorphosis. At metamorphosis effects on gonadal differentiation were evaluated using a subsample of frogs. Remaining animals were held unexposed for nine months, at which time reproductive organ structure, function and fertility were determined. LNG exposure severely impaired oviduct and ovary development and fertility. All adult females in the 0.5 nM group (n = 10) completely lacked oviducts. They also displayed a significantly larger fraction of immature oocytes, arrested in meiotic prophase, than control females. Upon mating with unexposed males, only one of 11 LNG-exposed females laid eggs, whereas all control females did. No effects on testicular development, sperm count or male fertility were observed. At metamorphosis, no effects on sex ratio or gonadal histology were evident. The effects on ovarian and oviductal development were detected at adult age but not at metamorphosis, emphasising the importance of investigating the long-term consequences of developmental exposure. This is the first developmental reproductive toxicity study of a progestin in an aquatic vertebrate. Considering that several progestins are present in contaminated surface waters, further investigation into the sensitivity of frogs to progestins is warranted to understand the risk such compounds may pose to wild frog populations." @default.
• W2009220815 created "2016-06-24" @default.
• W2009220815 creator A5013831629 @default.
• W2009220815 creator A5021605855 @default.
• W2009220815 creator A5044227579 @default.
• W2009220815 creator A5068859307 @default.
• W2009220815 date "2011-05-01" @default.
• W2009220815 modified "2023-09-23" @default.
• W2009220815 title "Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs" @default.
• W2009220815 cites W1967425557 @default.
• W2009220815 cites W1974908531 @default.
• W2009220815 cites W1984154784 @default.
• W2009220815 cites W1992534907 @default.
• W2009220815 cites W1994349548 @default.
• W2009220815 cites W2013112048 @default.
• W2009220815 cites W2016171854 @default.
• W2009220815 cites W2017769758 @default.
• W2009220815 cites W2029393824 @default.
• W2009220815 cites W2033609868 @default.
• W2009220815 cites W2039289088 @default.
• W2009220815 cites W2040282810 @default.
• W2009220815 cites W2043127462 @default.
• W2009220815 cites W2043499282 @default.
• W2009220815 cites W2051414725 @default.
• W2009220815 cites W2051716513 @default.
• W2009220815 cites W2052742763 @default.
• W2009220815 cites W2053977911 @default.
• W2009220815 cites W2061269636 @default.
• W2009220815 cites W2061717044 @default.
• W2009220815 cites W2062307674 @default.
• W2009220815 cites W2066449626 @default.
• W2009220815 cites W2076444283 @default.
• W2009220815 cites W2078687607 @default.
• W2009220815 cites W2084901619 @default.
• W2009220815 cites W2090168341 @default.
• W2009220815 cites W2090360937 @default.
• W2009220815 cites W2091883573 @default.
• W2009220815 cites W2097469040 @default.
• W2009220815 cites W2106241704 @default.
• W2009220815 cites W2109060290 @default.
• W2009220815 cites W2117609465 @default.
• W2009220815 cites W2121698479 @default.
• W2009220815 cites W2126912804 @default.
• W2009220815 cites W2138142695 @default.
• W2009220815 cites W2139826516 @default.
• W2009220815 cites W2144006294 @default.
• W2009220815 cites W2153615571 @default.
• W2009220815 cites W2160571481 @default.
• W2009220815 cites W97368944 @default.
• W2009220815 doi "https://doi.org/10.1016/j.aquatox.2011.02.003" @default.
• W2009220815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21392492" @default.
• W2009220815 hasPublicationYear "2011" @default.
• W2009220815 type Work @default.
• W2009220815 sameAs 2009220815 @default.
• W2009220815 citedByCount "71" @default.
• W2009220815 countsByYear W20092208152012 @default.
• W2009220815 countsByYear W20092208152013 @default.
• W2009220815 countsByYear W20092208152014 @default.
• W2009220815 countsByYear W20092208152015 @default.
• W2009220815 countsByYear W20092208152016 @default.
• W2009220815 countsByYear W20092208152017 @default.
• W2009220815 countsByYear W20092208152018 @default.
• W2009220815 countsByYear W20092208152019 @default.
• W2009220815 countsByYear W20092208152020 @default.
• W2009220815 countsByYear W20092208152021 @default.
• W2009220815 countsByYear W20092208152022 @default.
• W2009220815 countsByYear W20092208152023 @default.
• W2009220815 crossrefType "journal-article" @default.
• W2009220815 hasAuthorship W2009220815A5013831629 @default.
• W2009220815 hasAuthorship W2009220815A5021605855 @default.
• W2009220815 hasAuthorship W2009220815A5044227579 @default.
• W2009220815 hasAuthorship W2009220815A5068859307 @default.
• W2009220815 hasConcept C126322002 @default.
• W2009220815 hasConcept C134018914 @default.
• W2009220815 hasConcept C136397037 @default.
• W2009220815 hasConcept C16685009 @default.
• W2009220815 hasConcept C173758957 @default.
• W2009220815 hasConcept C18903297 @default.
• W2009220815 hasConcept C2776607906 @default.
• W2009220815 hasConcept C2777129507 @default.
• W2009220815 hasConcept C2778324911 @default.
• W2009220815 hasConcept C2781471917 @default.
• W2009220815 hasConcept C29730261 @default.
• W2009220815 hasConcept C42407357 @default.
• W2009220815 hasConcept C71315377 @default.
• W2009220815 hasConcept C71924100 @default.
• W2009220815 hasConcept C86803240 @default.
• W2009220815 hasConcept C99432707 @default.
• W2009220815 hasConceptScore W2009220815C126322002 @default.
• W2009220815 hasConceptScore W2009220815C134018914 @default.
• W2009220815 hasConceptScore W2009220815C136397037 @default.
• W2009220815 hasConceptScore W2009220815C16685009 @default.
• W2009220815 hasConceptScore W2009220815C173758957 @default.
• W2009220815 hasConceptScore W2009220815C18903297 @default.
• W2009220815 hasConceptScore W2009220815C2776607906 @default.
• W2009220815 hasConceptScore W2009220815C2777129507 @default.
• W2009220815 hasConceptScore W2009220815C2778324911 @default.
• W2009220815 hasConceptScore W2009220815C2781471917 @default.

• next