FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009225024> ?p ?o ?g. }

• W2009225024 endingPage "1642" @default.
• W2009225024 startingPage "1633" @default.
• W2009225024 abstract "The effects of lignocaine [lidocaine] HCl (0.6 microM(-1) mM) on the membrane electrical properties and action potential firing of neurones of the ventral posterolateral (VPL) nucleus of the thalamus were investigated using whole cell recording techniques in rat brain slices in vitro. Bath application of lignocaine reversibly decreased the input resistance (Ri) of VPL neurones. This effect was observed at low, clinically sedative and analgesic concentrations (i.e., maximal amplitude at 10 microM) whereas higher concentrations (300 microM(-1) mM) had no effect on Ri. Lignocaine (10-100 microM) depolarized VPL neurones up to 14 mV in a reversible manner. Consistent with a decreased Ri, low concentrations of lignocaine shunted the current required for spike generation in the tonic pattern. Lignocaine increased the threshold amplitude of current required for firing and decreased the tonic firing frequency, without concomitant elevation of the voltage threshold for firing or reduction in the maximal rate of rise (dV/dt(max)) of spikes. Low concentrations of lignocaine shunted low threshold spike (LTS) burst firing evoked either from hyperpolarized potentials or as rebound bursts on depolarization from prepulse-conditioned potentials. Higher concentrations of lignocaine (300 microM - 1 mM), not associated with a decrease in Ri, elevated the voltage threshold for firing and reduced the dV/dt(max) of spikes in a concentration-dependent fashion. In conclusion, low concentrations of lignocaine shunted tonic and burst firing in VPL neurones by decreasing Ri, a mechanism not previously described for local anaesthetics in the CNS. We suggest that a decreased resistance in thalamocortical neurones contributes to the sedative, analgesic, and anaesthetic properties of systemic lignocaine in vivo." @default.
• W2009225024 created "2016-06-24" @default.
• W2009225024 creator A5035697909 @default.
• W2009225024 creator A5076741407 @default.
• W2009225024 date "1998-08-01" @default.
• W2009225024 modified "2023-10-17" @default.
• W2009225024 title "Analgesic and sedative concentrations of lignocaine shunt tonic and burst firing in thalamocortical neurones" @default.
• W2009225024 cites W1480219974 @default.
• W2009225024 cites W1869612208 @default.
• W2009225024 cites W1965729052 @default.
• W2009225024 cites W1966818330 @default.
• W2009225024 cites W1970976878 @default.
• W2009225024 cites W1971356120 @default.
• W2009225024 cites W1973289495 @default.
• W2009225024 cites W1978667943 @default.
• W2009225024 cites W1980421773 @default.
• W2009225024 cites W1982899237 @default.
• W2009225024 cites W1999058855 @default.
• W2009225024 cites W1999622205 @default.
• W2009225024 cites W2009667219 @default.
• W2009225024 cites W2018638145 @default.
• W2009225024 cites W2033981388 @default.
• W2009225024 cites W2033989627 @default.
• W2009225024 cites W2037314052 @default.
• W2009225024 cites W2042284241 @default.
• W2009225024 cites W2045920319 @default.
• W2009225024 cites W2046300633 @default.
• W2009225024 cites W2071816031 @default.
• W2009225024 cites W2077406427 @default.
• W2009225024 cites W2078360083 @default.
• W2009225024 cites W2079776939 @default.
• W2009225024 cites W2095226579 @default.
• W2009225024 cites W2096389724 @default.
• W2009225024 cites W2099834228 @default.
• W2009225024 cites W2102267913 @default.
• W2009225024 cites W2117514707 @default.
• W2009225024 cites W2148901385 @default.
• W2009225024 cites W2156998133 @default.
• W2009225024 cites W21633769 @default.
• W2009225024 cites W2163686172 @default.
• W2009225024 cites W2163694327 @default.
• W2009225024 cites W2178459653 @default.
• W2009225024 cites W2219473100 @default.
• W2009225024 cites W2222037297 @default.
• W2009225024 cites W2272350308 @default.
• W2009225024 cites W2403611111 @default.
• W2009225024 cites W2410829842 @default.
• W2009225024 cites W4229627221 @default.
• W2009225024 cites W2003191811 @default.
• W2009225024 doi "https://doi.org/10.1038/sj.bjp.0702015" @default.
• W2009225024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565570" @default.
• W2009225024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9756378" @default.
• W2009225024 hasPublicationYear "1998" @default.
• W2009225024 type Work @default.
• W2009225024 sameAs 2009225024 @default.
• W2009225024 citedByCount "14" @default.
• W2009225024 countsByYear W20092250242015 @default.
• W2009225024 countsByYear W20092250242016 @default.
• W2009225024 countsByYear W20092250242020 @default.
• W2009225024 crossrefType "journal-article" @default.
• W2009225024 hasAuthorship W2009225024A5035697909 @default.
• W2009225024 hasAuthorship W2009225024A5076741407 @default.
• W2009225024 hasBestOaLocation W20092250242 @default.
• W2009225024 hasConcept C126322002 @default.
• W2009225024 hasConcept C127573956 @default.
• W2009225024 hasConcept C167639399 @default.
• W2009225024 hasConcept C169760540 @default.
• W2009225024 hasConcept C185263204 @default.
• W2009225024 hasConcept C185592680 @default.
• W2009225024 hasConcept C195221683 @default.
• W2009225024 hasConcept C2779246727 @default.
• W2009225024 hasConcept C2780820201 @default.
• W2009225024 hasConcept C4141045 @default.
• W2009225024 hasConcept C42219234 @default.
• W2009225024 hasConcept C522805319 @default.
• W2009225024 hasConcept C71924100 @default.
• W2009225024 hasConcept C86803240 @default.
• W2009225024 hasConceptScore W2009225024C126322002 @default.
• W2009225024 hasConceptScore W2009225024C127573956 @default.
• W2009225024 hasConceptScore W2009225024C167639399 @default.
• W2009225024 hasConceptScore W2009225024C169760540 @default.
• W2009225024 hasConceptScore W2009225024C185263204 @default.
• W2009225024 hasConceptScore W2009225024C185592680 @default.
• W2009225024 hasConceptScore W2009225024C195221683 @default.
• W2009225024 hasConceptScore W2009225024C2779246727 @default.
• W2009225024 hasConceptScore W2009225024C2780820201 @default.
• W2009225024 hasConceptScore W2009225024C4141045 @default.
• W2009225024 hasConceptScore W2009225024C42219234 @default.
• W2009225024 hasConceptScore W2009225024C522805319 @default.
• W2009225024 hasConceptScore W2009225024C71924100 @default.
• W2009225024 hasConceptScore W2009225024C86803240 @default.
• W2009225024 hasIssue "8" @default.
• W2009225024 hasLocation W20092250241 @default.
• W2009225024 hasLocation W20092250242 @default.
• W2009225024 hasLocation W20092250243 @default.
• W2009225024 hasLocation W20092250244 @default.
• W2009225024 hasOpenAccess W2009225024 @default.
• W2009225024 hasPrimaryLocation W20092250241 @default.

• next