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- W2009232246 abstract "Crithidia fasciculata, a nonpathogenic relative of the leishmanial and trypanosomal pathogens of humans and animals, showed a 3'-ribonucleotidase activity similar to that in Leishmania donovani. The level of 3'-nucleotidase activity in Crithidia was regulated by the availability of purines in the culture medium. Specifically, organisms obtained from culture medium depleted of purines contained elevated levels of enzyme activity compared to those grown in complete medium. The 3'-nucleotidase, located at the cell surface, may serve as a first step in purine salvage for these protozoa, which are unable to synthesize the purine ring de novo." @default.
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- W2009232246 date "1985-01-04" @default.
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- W2009232246 title "Enzyme Regulation in a Trypanosomatid: Effect of Purine Starvation on Levels of 3′-Nucleotidase Activity" @default.
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- W2009232246 doi "https://doi.org/10.1126/science.2981117" @default.
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